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Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites ....Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites to survive in the new host. Anticipated outcomes include the identification of new intervention strategies and improved transmission model systems for vector-borne diseases. This gained knowledge could provide benefits to future biomedical applications by informing diagnostics or treatment of lipid associated diseases.Read moreRead less
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100026
Funder
Australian Research Council
Funding Amount
$178,839.00
Summary
Ultrafast magic angle spinning solid-state nuclear magnetic resonance capability. This project aims to extend an existing nuclear magnetic resonance (NMR) spectrometer for structural investigations of proteins in the solid state. Many proteins, such as amyloids and flexible proteins, cannot be studied by X-ray crystallography, solution NMR spectroscopy or cryoelectron microscopy, because they cannot be crystallised or are not sufficiently soluble, or are structurally too heterogeneous. This proj ....Ultrafast magic angle spinning solid-state nuclear magnetic resonance capability. This project aims to extend an existing nuclear magnetic resonance (NMR) spectrometer for structural investigations of proteins in the solid state. Many proteins, such as amyloids and flexible proteins, cannot be studied by X-ray crystallography, solution NMR spectroscopy or cryoelectron microscopy, because they cannot be crystallised or are not sufficiently soluble, or are structurally too heterogeneous. This project will extend the capability of an existing 800 MHz NMR spectrometer to solid-state NMR. By offering ultrafast magic angle spinning speeds, the system aims to afford greatly enhanced sensitivity and multidimensional NMR spectra of protein systems not previously amenable to structural analysis by NMR spectroscopy or other techniques. This will have important applications in biotechnology and biomedicine.Read moreRead less
Pedalling for change: cultural geography for traffic congestion innovation. This project aims to offer new knowledge about why commuter cycling has failed to increase at a time when leisure cycling grows exponentially. The project seeks to provide evidence about what cycling enables people to achieve through analysis of a database of media discourses, policies and most importantly the experiences of cyclists. Expected outcomes include an enhanced understanding of cycling as response to congestio ....Pedalling for change: cultural geography for traffic congestion innovation. This project aims to offer new knowledge about why commuter cycling has failed to increase at a time when leisure cycling grows exponentially. The project seeks to provide evidence about what cycling enables people to achieve through analysis of a database of media discourses, policies and most importantly the experiences of cyclists. Expected outcomes include an enhanced understanding of cycling as response to congestion and improved policy strategies for increasing purposeful cycling in cities including moving the focus from cycling participation rates to cultures of cycling. Australia will benefit from cycling growing as a mode of transport to attenuate traffic congestion in metropolitan centres.Read moreRead less
ARC Centre of Excellence in Synthetic Biology. The ARC Centre of Excellence in Synthetic Biology (CoESB) will provide the technical innovation critical for Australia to develop a vibrant bioeconomy building on the nation’s strengths in agriculture. For thousands of years we have used microbes to create bread, wine, cheese. Now, our Centre will pioneer new approaches to the design of synthetic microbes, enabling the development of custom-designed microbial communities, synthetic organelles and ne ....ARC Centre of Excellence in Synthetic Biology. The ARC Centre of Excellence in Synthetic Biology (CoESB) will provide the technical innovation critical for Australia to develop a vibrant bioeconomy building on the nation’s strengths in agriculture. For thousands of years we have used microbes to create bread, wine, cheese. Now, our Centre will pioneer new approaches to the design of synthetic microbes, enabling the development of custom-designed microbial communities, synthetic organelles and new to nature biological pathways and enzymes. CoESB will combine engineering with molecular biology to design and construct novel biological systems that can convert biomass from agriculture or waste streams to biofuel, bioplastics and other high-value chemicals.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100027
Funder
Australian Research Council
Funding Amount
$320,000.00
Summary
Sensitive and multinuclear: a dedicated facility for high-throughput characterisation of small molecules. This project will provide new cutting edge nuclear magnetic resonance equipment will enhance an existing shared analysis facility based at University of New South Wales. The new equipment will underpin research in polymers, neuropharmacology, the biological basis of inherited disease, nanomedicine, bioactive compounds and toxins.
Ethical and Social Issues in Translating Epigenetics into Antenatal Care. This project aims to investigate how knowledge about the intergenerational transmission of health and disease is shaping antenatal care in Australia. It expects to generate new knowledge about how the science of epigenetics can be used to address social inequality and is anticipated to have impact across the social sciences, bioethics and public health. Expected outcomes of the project include novel theoretical approaches ....Ethical and Social Issues in Translating Epigenetics into Antenatal Care. This project aims to investigate how knowledge about the intergenerational transmission of health and disease is shaping antenatal care in Australia. It expects to generate new knowledge about how the science of epigenetics can be used to address social inequality and is anticipated to have impact across the social sciences, bioethics and public health. Expected outcomes of the project include novel theoretical approaches to the ethics of pregnancy, along with guidance tools to shape the use of epigenetics in antenatal care and social policy to reduce social inequalities. This should provide significant benefits, improving information and support available to vulnerable women as they negotiate maternal health and social services. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100085
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Regional facility for macromolecular x-ray crystallography. This facility in the southern NSW/ACT region will allow research into structures of biological molecules. Research at the facility will contribute to advances in understanding of processes in living organisms, new drugs and new biotechnology with national and international significance.
Investigating The Cellular Response To Iron-Depletion: The Trilogy Of ASK1, Thioredoxin And Ribonucleotide Reductase
Funder
National Health and Medical Research Council
Funding Amount
$552,572.00
Summary
Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for t ....Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.Read moreRead less