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Blood component interactions with polysaccharide biomaterials for vascular applications. Heart disease is the major killer of people in Australia and the Western world. It is due mainly to the blockage of vessels supplying the muscle of the heart with blood and nutrients, which can be replaced or by-passed but the supply of native vessels in the body is limited. Tissue engineering laboratories have been trying to develop blood vessels for this use for many years without significant success. T ....Blood component interactions with polysaccharide biomaterials for vascular applications. Heart disease is the major killer of people in Australia and the Western world. It is due mainly to the blockage of vessels supplying the muscle of the heart with blood and nutrients, which can be replaced or by-passed but the supply of native vessels in the body is limited. Tissue engineering laboratories have been trying to develop blood vessels for this use for many years without significant success. This application plans to understand the molecular signals contained within the sugar sequences used in a commonly used biomaterial chitosan that may be used in the construction of synthetic vascular grafts. If we can understand how blood cells interact with this biomaterial, we may be able to develop a blood vessel in the laboratory.Read moreRead less
A novel platform for the biosynthesis of commercially valuable saxitoxins. Saxitoxins are potent microbial toxins, which pose a significant threat to food and water quality. Highly pure saxitoxins are required for environmental monitoring and studies of cell physiology. Certain analogues have also shown promise as long-lasting and non-addictive pain blockers. However, the procurement of these compounds from natural sources is convoluted and unsustainable. This project aims to use the latest synt ....A novel platform for the biosynthesis of commercially valuable saxitoxins. Saxitoxins are potent microbial toxins, which pose a significant threat to food and water quality. Highly pure saxitoxins are required for environmental monitoring and studies of cell physiology. Certain analogues have also shown promise as long-lasting and non-addictive pain blockers. However, the procurement of these compounds from natural sources is convoluted and unsustainable. This project aims to use the latest synthetic biology techniques to characterise, modify and express saxitoxin biosynthesis pathways, thereby providing a sustainable source of toxin analogues of value to industry and research. This novel 'green technology' will benefit the environment, human health and the Australian economy.Read moreRead less
Integrated Futures for the use of Motorised Mobility Devices. People using Motorised Mobility Devices (MMDs) face increased regulation. A pessimism exists about the future of MMDs because of the lack of evidence and explanation of MMD use in transport decision making. This project aims to fundamentally change knowledge about the everyday meanings and experiences of MMDs. The project seeks to provide comparative, trustworthy and in-depth baseline empirical data about how people who are reliant u ....Integrated Futures for the use of Motorised Mobility Devices. People using Motorised Mobility Devices (MMDs) face increased regulation. A pessimism exists about the future of MMDs because of the lack of evidence and explanation of MMD use in transport decision making. This project aims to fundamentally change knowledge about the everyday meanings and experiences of MMDs. The project seeks to provide comparative, trustworthy and in-depth baseline empirical data about how people who are reliant upon MMDs negotiate the current transport infrastructure. Expected outcomes with our Partner Organisation, Assistive Technology Services Australia, include a database of deliberative strategies. This project will benefit Australia’s urban and regional communities through a better understanding of transport. Read moreRead less
Unleashing the Hidden Chemical Diversity in Australian Fungi. This project aims to exploit an exclusive genomic resource consisting of >150 unique Australian filamentous fungi that has been built in a university-industry collaboration for genomic-guided biodiscovery. The genome sequence of these fungi revealed extensive hidden genetic instructions for production of novel biologically active molecules. The project will apply cutting-edge synthetic biology and chemical tools to tap into the hidden ....Unleashing the Hidden Chemical Diversity in Australian Fungi. This project aims to exploit an exclusive genomic resource consisting of >150 unique Australian filamentous fungi that has been built in a university-industry collaboration for genomic-guided biodiscovery. The genome sequence of these fungi revealed extensive hidden genetic instructions for production of novel biologically active molecules. The project will apply cutting-edge synthetic biology and chemical tools to tap into the hidden genomic potential of these Australian fungi. Expected outcomes of this project include new fine chemicals and lead molecules with desirable bioactivies. This will provide significant benefits to Australia's economy through the discovery of new pharmaceuticals, veterinary products and agrichemicals.Read moreRead less
Rip currents: an evidence based approach to managing the greatest beach hazard. For the first time, an understanding of the action of swimmers caught in rip currents will be linked through interviews with rip current survivors and measurements of swimmer response and rip flow. This project will provide information that will improve existing rip current education and assist in reducing the unacceptably high drowning toll on Australian beaches.
Contraception understandings and experiences of Australian women. Most women use contraception for much of their lives, yet we know little about how they experience the effects on their bodies and relationships. This in-depth study will explore women's thoughts, feelings and experiences and the results will be used for training doctors and nurses in contraceptive counselling and prescribing.
Human resource information systems (HRIS) and the strategic significance of the human resource function. A large number of Australian organisations have invested in computer based HRIS. Used effectively, HRIS can allow HR to realise its strategic potential and to contribute to improved organisational performance. This project will contribute to the national research priority on frontier technologies, by enhancing understanding of the conditions that allow for smart information use, thereby contr ....Human resource information systems (HRIS) and the strategic significance of the human resource function. A large number of Australian organisations have invested in computer based HRIS. Used effectively, HRIS can allow HR to realise its strategic potential and to contribute to improved organisational performance. This project will contribute to the national research priority on frontier technologies, by enhancing understanding of the conditions that allow for smart information use, thereby contributing to the nation's economic competitiveness.Read moreRead less
Values Enactment Training, Values Congruence, and Emotional Intelligence: A Field Experiment. This research will develop a practical training strategy to reduce the gap between values statements and employee behaviour in Australian organisations. More specifically, the training at Main Roads WA will enhance the organisation's performance, competitiveness, and cost-effectiveness through better alignment of on-the-job behaviour with key corporate values. Potentially, road infrastructure improvemen ....Values Enactment Training, Values Congruence, and Emotional Intelligence: A Field Experiment. This research will develop a practical training strategy to reduce the gap between values statements and employee behaviour in Australian organisations. More specifically, the training at Main Roads WA will enhance the organisation's performance, competitiveness, and cost-effectiveness through better alignment of on-the-job behaviour with key corporate values. Potentially, road infrastructure improvement will result. This study will also provide better understanding and practical recommendations regarding the role of emotional intelligence in management training and values enactment. A third benefit shall be the delivery of practical human resource management recommendations to aid the realisation of values congruence across organisations.Read moreRead less
Pancreatic Differentiation of Cord Blood Stem Cells using Smart Surfaces. Cord blood cells obtained at the time of delivery of a baby are a valuable resource that have the potential to develop into many cell types. This Project entails attaching stem cells derived from cord blood to appropriate 3 dimensional smart surfaces, and examining the ability of such cells to develop into insulin-producing cells. An understanding of how to coax stem cells, seeded on to smart surfaces, to develop into ma ....Pancreatic Differentiation of Cord Blood Stem Cells using Smart Surfaces. Cord blood cells obtained at the time of delivery of a baby are a valuable resource that have the potential to develop into many cell types. This Project entails attaching stem cells derived from cord blood to appropriate 3 dimensional smart surfaces, and examining the ability of such cells to develop into insulin-producing cells. An understanding of how to coax stem cells, seeded on to smart surfaces, to develop into mature cells with different functions will enhance our ability to understand how cells develop. As well, it enhance the potential usefulness of cord blood for research purposes. Read moreRead less
Work, care, retirement and health: ageing agendas. This project will undertake a gendered analysis of how Australians can retire well, taking account of their key resources (such as work, superannuation, the aged pension, and other assets) and key demands (such as to work longer and to care for others in the context of an ageing population and a more feminised workforce).