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Interrogation Of Two Novel Genetic Susceptibility Loci For Multiple Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$840,615.00
Summary
This proposal, from the Australia and New Zealand multiple sclerosis (MS) Genetics Consortium, aims to interrogate two new genes that it recently identified as predisposing for the development of MS. Both of the genes underlying these findings are also associated with risk of developing other autoimmune diseases such as type 1 diabetes, rheumatoid arthritis and Graves' disease.
Climate Change And Rural Communities: Integrated Study Of Physical And Social Impacts, Health Risks And Adaptive Options
Funder
National Health and Medical Research Council
Funding Amount
$611,599.00
Summary
Rural Australia has begun to experience climate change impacts - which will increase in future. Losses in farm yields, water supplies, property, community morale and family incomes have diverse health effects. We will study the separate and joint effects of climate change and associated extreme events (e.g., bushfires) on selected health outcomes. Using integrative methods, we will clarify the main influences on health risks, their future projections, and how best to intervene to lessen risks.
Whether holding the arm still or standing, the brain uses a silent proprioceptive sense that unconsciously detects and controls our movements. Key sensory receptors for this sense are located within the muscles that are also contracting. This is a project to discover how proprioception is affected by muscle contraction and how this affects postural control. This will improve the management of many common disorders that affect movement and balance.
Human Factors And Patient Safety During Paediatric Heart Surgery: An Evidence-based Approach To Improve Patient Outcomes
Funder
National Health and Medical Research Council
Summary
The research project aims to improve outcomes of children undergoing repair of heart birth defects. The novel study is devised to engage health care providers in the re-design of surgical interventions to improve child outcomes. The collaborative approach of engaging health care providers and carers in the design of improvement interventions can help overcome the implementation gap and ensure rapid improvement and enhanced patient safety of children undergoing heart surgery repair.
Phenotypic And Functional Characterization Of Human Dendritic Cell Subsets Generated In Vitro And Isolated From Tissues
Funder
National Health and Medical Research Council
Funding Amount
$586,428.00
Summary
The immune system defends us against infections and cancer. Dendritic cells (DC) are white blood cells that have a central role to both activate the immune system and to regulate immune responses. In this study, we will determine the functional differences of human DC populations, because a clear understanding of the functional differences between different human DC types is essential for utilizing DC in designing more effective vaccines and immune therapies for clinical applications.