Using Law To Improve Population Health and the Quality of Health Care Services. There are huge gaps in our understanding of how legal rules and processes impact population health and the quality of health care services in Australia. This research program will begin to fill those gaps by addressing topical issues such as medical negligence litigation, the coroner's role in injury prevention, and the use of medical science in the courtroom. The findings will be useful to government policymakers, ....Using Law To Improve Population Health and the Quality of Health Care Services. There are huge gaps in our understanding of how legal rules and processes impact population health and the quality of health care services in Australia. This research program will begin to fill those gaps by addressing topical issues such as medical negligence litigation, the coroner's role in injury prevention, and the use of medical science in the courtroom. The findings will be useful to government policymakers, regulators, and judges, as well as professionals working in both the legal and health care fields. But most importantly, the findings will serve patients by helping to shape strategies and reforms that enable Australia's health care system to deliver services that are safer, of higher quality, fairer, and more efficient.Read moreRead less
Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in ....Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework. This will be used on an exemplar application for lineage commitment in haematopoiesis and for exploring and validating genetic regulatory models in general.Read moreRead less
Biocompatible Ionic Liquids - Preserving Bioactive Structure and Function. A family of liquids recently discovered at Monash University has an ability to preserve bioactive molecules that represents a breakthrough in biotechnology. These new biocompatible ionic liquids will be investigated for applications in the treatment of diseases such as haemophilia. The ability of these liquids to stabilise a wide range of enzymes also opens up the potential of their use in a range of biosensors such as b ....Biocompatible Ionic Liquids - Preserving Bioactive Structure and Function. A family of liquids recently discovered at Monash University has an ability to preserve bioactive molecules that represents a breakthrough in biotechnology. These new biocompatible ionic liquids will be investigated for applications in the treatment of diseases such as haemophilia. The ability of these liquids to stabilise a wide range of enzymes also opens up the potential of their use in a range of biosensors such as blood glucose monitors for diabetes management. In collaborations with research groups worldwide, these materials will also be applied to the preservation of bioactivity in applications including cryopreservation of endangered species such as coral and in medical therapeutics. Read moreRead less
Advanced analysis, behaviour and design of steel and steel-concrete composite engineering structures subjected to elevated temperatures. This Fellowship aims to develop a consistent advanced nonlinear method for the analysis and behaviour of steel and composite building frames that are subjected to elevated temperatures. There is widespread feeling amongst practitioners that, in the absence of reliable techniques for verifying this behaviour, the regulatory need for fire protection of steel is ....Advanced analysis, behaviour and design of steel and steel-concrete composite engineering structures subjected to elevated temperatures. This Fellowship aims to develop a consistent advanced nonlinear method for the analysis and behaviour of steel and composite building frames that are subjected to elevated temperatures. There is widespread feeling amongst practitioners that, in the absence of reliable techniques for verifying this behaviour, the regulatory need for fire protection of steel is excessive, and the high expense involved in providing this protection is leading structural steel being rejected in engineering design. This growing trend is leading to a potential downturn in structural steel production, which has serious economic and social ramifications on Australian communities whose fabric is centred on this activity.Read moreRead less
Advanced Molecular Nanomaterials. The design and construction of advanced nanomaterials is a key step in the push towards smarter and more efficient high-level technologies. Here we mount a major research program into the strategic assembly of molecular nanomaterials that have entirely new and highly useful properties. This innovative work will lead to important fundamental advances in nanoscience and will forge deep understandings of how materials properties relate to nanoscale structure. Th ....Advanced Molecular Nanomaterials. The design and construction of advanced nanomaterials is a key step in the push towards smarter and more efficient high-level technologies. Here we mount a major research program into the strategic assembly of molecular nanomaterials that have entirely new and highly useful properties. This innovative work will lead to important fundamental advances in nanoscience and will forge deep understandings of how materials properties relate to nanoscale structure. These advances will spur a wide range of important new technologies, with application of the materials in electronics, photonics, molecular sensing, drug synthesis and purification, clean energy and the controlled release of agrochemicals and pharmaceuticals.Read moreRead less
Principles of Quantum Information Science. The use of quantum mechanical systems to carry and process information is enabling a revolution in information technology through innovations such as quantum computation and quantum teleportation. This project investigates the fundamental theory of quantum information science. The project aims to formulate general principles governing the power and behaviour of quantum information. These principles will, in turn, enable the development of powerful new ....Principles of Quantum Information Science. The use of quantum mechanical systems to carry and process information is enabling a revolution in information technology through innovations such as quantum computation and quantum teleportation. This project investigates the fundamental theory of quantum information science. The project aims to formulate general principles governing the power and behaviour of quantum information. These principles will, in turn, enable the development of powerful new applications of quantum information. Principal areas to be addressed include: general conditions for a physical system to be usable for quantum computation, the development of new algorithms for quantum computers, the development of new quantum communication protocols, and the theory of quantum entanglement.Read moreRead less
Nonparametric Statistical Methods -- New Directions, Theory and Applications. The research program will take Australia to the forefront of contemporary work in nonparametric statistics, and assist greatly in the training of a new generation of Australian statistical scientists. It will contribute significantly to restoring the health of this strategically important field, in Australian universities and in the nation more generally. The projects outlined in the proposal address problems arising ....Nonparametric Statistical Methods -- New Directions, Theory and Applications. The research program will take Australia to the forefront of contemporary work in nonparametric statistics, and assist greatly in the training of a new generation of Australian statistical scientists. It will contribute significantly to restoring the health of this strategically important field, in Australian universities and in the nation more generally. The projects outlined in the proposal address problems arising in astronomy, economics, engineering, defence, health and image analysis, but the potential areas of impact are broader even than this. This diversity illustrates the extraordinary potential, and strategic significance, of statistics to Australia. Read moreRead less
RUSSIA (THE SOVIET UNION) AND AUSTRALIA IN THE 20TH AND 21ST CENTURIES. Revitalize Australian Russian studies by bringing in internationally recognized leadership and cutting-edge projects; making the University of Melbourne's Russian centre not just the southern hemisphere leader in this field but also a significant player worldwide.
Beyond Microarrays: Nano-Scaled Devices for High Throughput Biomolecular Sensing. Current developments in Nanoscience and Nanotechnology hold many promises in terms of revolutionising our industrial base, transforming biology, medical science and practice. This project strives to achieve some of these aims by, for the first time, building and testing nano-scaled devices with the capability to 'read' massive amounts of biological information. With the recent completion of the Human Genome proje ....Beyond Microarrays: Nano-Scaled Devices for High Throughput Biomolecular Sensing. Current developments in Nanoscience and Nanotechnology hold many promises in terms of revolutionising our industrial base, transforming biology, medical science and practice. This project strives to achieve some of these aims by, for the first time, building and testing nano-scaled devices with the capability to 'read' massive amounts of biological information. With the recent completion of the Human Genome project, major opportunities exist to provide spectacular advances in human health care (eg, via personalised medicine) provided that appropriate high-throughput biological reading devices can be developed. In developing such devices, this project also aims to substantially catalyse the Australian Nanotechnology/Biotechnology industry.Read moreRead less
lll-conditioned and constrained inverse problems in Signal Processing, Telecommunications and Control. Aims: To carry out fundamental research on methods for understanding and solving inverse problems in signal processin, telecommunications and control. To translate these fundamental results into practical outcomes of importance to Australian Industry.
Significance: Signal Processing, Telecommunications and Control are core technologies for all modern societies. The research proposed here ....lll-conditioned and constrained inverse problems in Signal Processing, Telecommunications and Control. Aims: To carry out fundamental research on methods for understanding and solving inverse problems in signal processin, telecommunications and control. To translate these fundamental results into practical outcomes of importance to Australian Industry.
Significance: Signal Processing, Telecommunications and Control are core technologies for all modern societies. The research proposed here will generate new methods for designing and understanding key algorithms in these areas. Particular emphasis will be placed on difficult problems involving ill-conditioned inverses or those having hard constraints that must be satisfied.
Expected Outcomes: A prime outcome will be fundamental research results at the highest international level. This will be accompanied by top level refereed publications and books. There will also be direct and tangible benefits to Australian industry.Read moreRead less