Evolutionary history and impact of adeno-associated viruses in Australia. Recently accrued evidence identifies Australia as an ideal closed-model system in which to elucidate the evolutionary history of a group of non-pathogenic viruses, known as adeno-associated viruses (AAVs). This project aims to trace back the evolutionary history of AAVs for tens of millions of years via molecular fossil imprints left behind by ancient viral invasions of Australian marsupial genomes. Concurrently, the poten ....Evolutionary history and impact of adeno-associated viruses in Australia. Recently accrued evidence identifies Australia as an ideal closed-model system in which to elucidate the evolutionary history of a group of non-pathogenic viruses, known as adeno-associated viruses (AAVs). This project aims to trace back the evolutionary history of AAVs for tens of millions of years via molecular fossil imprints left behind by ancient viral invasions of Australian marsupial genomes. Concurrently, the potential impact that these viral invasions had on the evolutionary development of their ancestral hosts will be investigated. This could facilitate previously unattainable insights into both AAV and marsupial evolution, with broader implications relevant to the advancement of the fields of virology and mammalian evolution.Read moreRead less
Contact Networks, Immunity, and Evolution in Competing Cancer Epidemics. The project aims to evaluate evolutionary interactions between two transmissible cancer epidemics affecting Tasmanian devils and quantify their feedback on infection risk and epidemic behaviour. Using contact tracing and a phylogenetic framework we aim to quantify how tumour lineages evolve with each generation of infection and their effects on susceptibility to infection and disease progression. We expect to reveal the hos ....Contact Networks, Immunity, and Evolution in Competing Cancer Epidemics. The project aims to evaluate evolutionary interactions between two transmissible cancer epidemics affecting Tasmanian devils and quantify their feedback on infection risk and epidemic behaviour. Using contact tracing and a phylogenetic framework we aim to quantify how tumour lineages evolve with each generation of infection and their effects on susceptibility to infection and disease progression. We expect to reveal the host immuno-genetic basis underpinning cancer suppression and the adaptive capacity of populations in response to infectious diseases. This should significantly improve our ability to understand and manage this and other epidemic outbreaks in wildlife, as well as advancing our knowledge in cancer ecology and evolution.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101116
Funder
Australian Research Council
Funding Amount
$370,159.00
Summary
Adaptations in Tasmanian devil facial tumour disease. This project aims to understand how defence mechanisms against infectious diseases arise and evolve in nature. Infectious diseases exert strong evolutionary pressures on populations, forcing the development of adaptive strategies to fight the costs of infection. The project aims to determine individual differences in response to infection and how these affect population-scale transmission and evolutionary dynamics under natural and managed sc ....Adaptations in Tasmanian devil facial tumour disease. This project aims to understand how defence mechanisms against infectious diseases arise and evolve in nature. Infectious diseases exert strong evolutionary pressures on populations, forcing the development of adaptive strategies to fight the costs of infection. The project aims to determine individual differences in response to infection and how these affect population-scale transmission and evolutionary dynamics under natural and managed scenarios. This is expected to reveal populations’ adaptive capability and resilience against diseases and the effects of management interventions in controlling disease outbreaks and preventing population declines or extinctions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100059
Funder
Australian Research Council
Funding Amount
$350,790.00
Summary
Advanced high resolution biomolecular analysis facility for Tasmania. This project aims to establish an advanced, multi-purpose mass spectrometry platform for high-throughput and targeted biomolecular analysis, including proteomics and metabolomics. The purpose of the project is to provide a centralised state-of-the-art facility that supports research programs in plant science, agricultural research, food safety, animal and human health research and separation science. Potential benefits from th ....Advanced high resolution biomolecular analysis facility for Tasmania. This project aims to establish an advanced, multi-purpose mass spectrometry platform for high-throughput and targeted biomolecular analysis, including proteomics and metabolomics. The purpose of the project is to provide a centralised state-of-the-art facility that supports research programs in plant science, agricultural research, food safety, animal and human health research and separation science. Potential benefits from the project include increased agricultural productivity and food security, improved knowledge of age and injury-related changes in neurophysiology, helping to prevent the extinction of iconic Tasmanian wildlife and the development of advanced micro-electroseparation technologies.Read moreRead less
Development of an immune enhancing vaccine to protect Tasmanian devils against a contagious cancer. The iconic Tasmanian devil is threatened with extinction from a uniformly fatal transmissible facial cancer. Our team has shown in proof of concept that the cancer cells can be recognised by the devil immune system. This project will develop and test a vaccine against the tumour, which will ultimately protect devils in the wild.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100183
Funder
Australian Research Council
Funding Amount
$715,000.00
Summary
An ICP-ToF-MS facility for environmental, mineral and biological science. This project aims at establishing a facility for the detection, quantification and rapid mapping of elements and their isotopes in nanoparticles and a diverse set of biological and earth materials. The facility consists of a latest generation ICP-ToF-MS that can simultaneously collect a full suite of isotopic information (Li to U) from liquid samples or, in combination with laser ablation and laser induced breakdown spectr ....An ICP-ToF-MS facility for environmental, mineral and biological science. This project aims at establishing a facility for the detection, quantification and rapid mapping of elements and their isotopes in nanoparticles and a diverse set of biological and earth materials. The facility consists of a latest generation ICP-ToF-MS that can simultaneously collect a full suite of isotopic information (Li to U) from liquid samples or, in combination with laser ablation and laser induced breakdown spectroscopy, solid samples. It will enhance capabilities and sample throughput in environmental science, geoscience, biology and cultural heritage research, significantly accelerating the discovery of new ore bodies, improving environmental risk assessment and assisting research in cancer biology.Read moreRead less