Structural Role Of The Host Cytoskeleton During Invasion Of Intracellular Pathogens
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
During infection by bacteria, the 'skeleton' of cells plays critical roles in sensing the invading germs and destroying them. To counteract this, bacteria have evolved strategies to hijack the cell skeleton to promote their own survival, and spread. This intriguing molecular arms race is continuously co-evolving. Understanding this process in great details will have the potential to design novel therapeutics to counteract bacterial and viral infections.
Understanding Immunity To Influenza B Viruses For A Rationally Designed Universal Vaccine
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Influenza B viruses (IBV) circulate annually and are particularly prevalent and severe in children. However, IBV remain largely understudied. Our immune system provides protection against IBV via a variety of mechanisms. This study will characterize the immunity to IBV and dissect host-virus interactions which provide protection from IBV infection. This project will inform the rational design of novel vaccines eliciting universal immunity to IBV, with an ultimate goal of controlling IBV.
Genomics For Combating Antimicrobial Resistant Bacterial Pathogens
Funder
National Health and Medical Research Council
Funding Amount
$2,027,364.00
Summary
Applying genomics to bacterial pathogens is revolutionising the way we understand infectious diseases and antimicrobial resistance (AMR). There is a major opportunity to now bring the technology into routine clinical and public health practice. This research program will investigate and deliver the technology of pathogen genomics directly into public health disease surveillance, outbreak detection and the diagnosis and response to infectious diseases and AMR in hospitalised patients.
Crosstalk Between The Repressive Histone Methyltransferases PRC2 And G9A: Structure-function Investigation To Open New Therapeutic Opportunities
Funder
National Health and Medical Research Council
Funding Amount
$595,205.00
Summary
The gene expression programs need to be precisely regulated and the misregulation of these programs can cause a broad range of human diseases. My research will focus on two protein complexes, which heavily contribute to the regulation of gene expression. My study will open a new path for developing new therapeutic strategies.