Predictors Of Home Telehealth Adoption In The Aging Population: Consumer Perspectives
Funder
National Health and Medical Research Council
Funding Amount
$325,255.00
Summary
Care of the aging population will place a huge burden on the Australian healthcare system. It is now possible for health services to be provided across the Internet (telehealth) into the aged person’s home. The problem is there has been a slow uptake of telehealth services. What is needed is a clear understanding of aged consumers’ perspectives on telehealth and why they would engage in such services. These findings will assist in planning health care services for the aged into the future.
Benefits And Costs Of Home-based Pulmonary Rehabilitation In Chronic Obstructive Pulmonary Disease
Funder
National Health and Medical Research Council
Funding Amount
$364,361.00
Summary
Pulmonary rehabilitation is a highly effective treatment for people with the chronic lung disease known as COPD, but in Australia it is delivered to less than 1% of those who would benefit each year. This study will test a new, entirely home-based pulmonary rehabilitation model, and compare its benefits and costs to a standard hospital program. If home-based pulmonary rehabilitation can be delivered successfully at low cost, this will improve the health and quality of life of people with COPD in ....Pulmonary rehabilitation is a highly effective treatment for people with the chronic lung disease known as COPD, but in Australia it is delivered to less than 1% of those who would benefit each year. This study will test a new, entirely home-based pulmonary rehabilitation model, and compare its benefits and costs to a standard hospital program. If home-based pulmonary rehabilitation can be delivered successfully at low cost, this will improve the health and quality of life of people with COPD in Australia and around the world.Read moreRead less
A Telehealth Mediated Nursing Intervention (PRISMS) To Enable Patient Monitoring And Self-care In Haematological Cancer Patients: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$936,632.00
Summary
People with cancer are required to monitor and to initiate self care activities to manage side effects at home. In haematological cancer patients these side effects are often severe and life-threatening. Safe home care requires close communication with the health team. We will test if a mobile phone based system can: support patients to monitor their side effects; promote the delivery of evidence based self care advice in a timely manner; and mediate the role of nurses to effectively provide rea ....People with cancer are required to monitor and to initiate self care activities to manage side effects at home. In haematological cancer patients these side effects are often severe and life-threatening. Safe home care requires close communication with the health team. We will test if a mobile phone based system can: support patients to monitor their side effects; promote the delivery of evidence based self care advice in a timely manner; and mediate the role of nurses to effectively provide real-time patient support.Read moreRead less
Closing The Gap: Early Childhood Sustained Home Visiting For Families Of Aboriginal Infants In An Urban Community
Funder
National Health and Medical Research Council
Funding Amount
$2,244,402.00
Summary
The study aims to determine whether a sustained structured nurse home visiting (SSNVH) program is effective for Aboriginal families. In the context of increased government investment in home visiting programs for Indigenous children, this study will help to answer three critical questions: (1) Does SSNHV result in improved outcomes for Aboriginal infants? (2) Is SSNHV equally effective for Aboriginal and non-Aboriginal infants?(3) What are the issues in adaptation and implementation?
Gene-environment Interactions In The Aetiology Of Myopia
Funder
National Health and Medical Research Council
Funding Amount
$671,285.00
Summary
The rapid rise in the prevalence of shortsightedness poses a major public health challenge. The Sydney Myopia Study has collected a large database on environmental risk factors, and has documented a major protective effect of children spending more time outdoors. Other studies suggest that myopia has a major genetic component. This study will collect DNA samples from over 4000 participants in the Sydney Myopia Study, and through genome-wide scanning, will look for gene-environment interactions.
Defining Factors That Contribute To Individual Diversity In The Diet-health Axis
Funder
National Health and Medical Research Council
Funding Amount
$1,668,059.00
Summary
There is a complex interplay between nutrition and genetics such that one diet maybe good for some but not for others depending on genetic makeup. Preliminary experiments in flies and mice support this. We found that for some flies, diets high in fat are harmful resulting in short life but certain flies resist the harmful effects of fat and live a longer lives. We propose to unravel the gene-environment interaction and determine which genes might lead to optimal health outcomes on certain diets.
Deciphering Specific Roles For The Common Arnt Proteins In BHLH/PAS Transcription Factor Complexes
Funder
National Health and Medical Research Council
Funding Amount
$526,421.00
Summary
Understanding the precise control of neuronal genes related to appetite and obesity, and neuropsychiatric disorders and dementia, is complicated by some gene regulating proteins having highly related sequences. This project will eludcidate how two closely related proteins can determine specific target gene outputs, information important for designing methods to control activities of neurological disease related genes within cells.
Complex Statistical Analyses Of Genome-wide Association Studies Related To Breast And Prostate Cancers Using High Performance Supercomputing
Funder
National Health and Medical Research Council
Funding Amount
$656,073.00
Summary
Breast and prostate cancers are the most common cancers in Australian women and men. Simple analyses of genome-wide association (GWAS) studies explain only a fraction of why these cancers run in families. The University of Melbourne now has a supercomputer that can conduct much more complex analyses. We will apply these to the world’s GWAS data for breast and prostate cancers. We hope to learn more about the causes of these cancers, and expand an expert Australian workforce in supercomputing.
Impact Of Social Adversity On The Developmental Trajectory To Mental Illness: A Study Of A Whole-population Cohort Of Children At Familial High-risk For Psychotic Disorders
Funder
National Health and Medical Research Council
Funding Amount
$822,385.00
Summary
The objective of this study is to use the rich multi-generational data collection that we have assembled on the life course of a large whole-population birth cohort and their parents to address specific research questions on the contribution of social adversity to the pathogenesis of mental illness, taking into account the interplay of social adversity with genetic risk and the range of other contributing factors on the developmental trajectory to mental illness.
Investigating Tumour Initiation And Growth In A Panel Of Mice Defective In Epigenetic Reprogramming.
Funder
National Health and Medical Research Council
Funding Amount
$421,600.00
Summary
Until recently it was believed that cancer is always caused by mutations in genes. Now it has been proposed that chemical modifications to the DNA and the proteins that package the DNA may also initiate cancer. These "epigenetic" modifications control whether our genes are switched on or off. Epigenetic modifications are disrupted in cancer, but it is not known whether they can start tumour growth. I will study this using mouse models. This work may lead to preventative screening and new treatme ....Until recently it was believed that cancer is always caused by mutations in genes. Now it has been proposed that chemical modifications to the DNA and the proteins that package the DNA may also initiate cancer. These "epigenetic" modifications control whether our genes are switched on or off. Epigenetic modifications are disrupted in cancer, but it is not known whether they can start tumour growth. I will study this using mouse models. This work may lead to preventative screening and new treatments in humans.Read moreRead less