Resolving the impact of pressure on hot and low-oxygen combustion. Despite the important role of renewable energy sources, combustion will remain essential for transportation into the foreseeable future. This project aims to investigate flames burning in a hot and low-oxygen environment. The objective is to better understand how these conditions could be applied to gas turbines. This project expects to generate new knowledge to enable a reduction in emissions, improvement in efficiency and incre ....Resolving the impact of pressure on hot and low-oxygen combustion. Despite the important role of renewable energy sources, combustion will remain essential for transportation into the foreseeable future. This project aims to investigate flames burning in a hot and low-oxygen environment. The objective is to better understand how these conditions could be applied to gas turbines. This project expects to generate new knowledge to enable a reduction in emissions, improvement in efficiency and increase in power output. Expected outcomes of this project include improved understanding of the governing physics to enable development of design tools for next-generation engines. This should provide significant benefits, such as reduced reliance on fossil fuels and a critical reduction in greenhouse gas emissions.Read moreRead less
Next-generation computational models to understand human joints . This project aims to investigate human joint systems through combining state-of-the-art imaging and high-fidelity biomechanical models. The methods developed in this project are expected to generate new ways of studying the dynamic response of musculoskeletal tissues to activity, including how musculoskeletal physiology can adapt to biomechanical stimuli. Expected outcomes include establishing a non-invasive method for characteris ....Next-generation computational models to understand human joints . This project aims to investigate human joint systems through combining state-of-the-art imaging and high-fidelity biomechanical models. The methods developed in this project are expected to generate new ways of studying the dynamic response of musculoskeletal tissues to activity, including how musculoskeletal physiology can adapt to biomechanical stimuli. Expected outcomes include establishing a non-invasive method for characterising whole joint systems. This project will provide significant knowledge gain on the biomechanical regulation of human joints across form, function, dynamics and loading which may help across many facets of society to guide physical activity choices.Read moreRead less
The microbe factory: a novel approach to benign minerals processing. The purpose of this project is to reduce the environmental impact of current mining practices. The anticipated outcome of this project is the replacement of toxic chemicals used in the separation of minerals with the novel use of environmentally benign microbes.
Blue energy harvesting and storage technology for wearable electronics. This project aims to develop new self-charging power devices that can harvest and store body energy generated during body motions, and power smart and implantable medical electronics. The project will develop new Piezo-supercapacitors by designing new electrode materials and cell designs. The charge storage and transport kinetics will be uncovered using advanced in-situ characterisation techniques and modern simulation metho ....Blue energy harvesting and storage technology for wearable electronics. This project aims to develop new self-charging power devices that can harvest and store body energy generated during body motions, and power smart and implantable medical electronics. The project will develop new Piezo-supercapacitors by designing new electrode materials and cell designs. The charge storage and transport kinetics will be uncovered using advanced in-situ characterisation techniques and modern simulation methods. The project expects to generate new knowledge in blue energy harvesting and storage systems, training for young scientists, and generate intellectual property with potential commercialised products to be used in implantable devices, placing Australia at the forefront of new technology.Read moreRead less
Graphic Encounters: Colonial Prints and the Inscription of Aboriginality. This project plans to collate the archive of prints depicting Indigenous Australians, from national and international collections, to ask how people's place in this newly encroached territory was inscribed by colonial prints. Before the 1890s, prints (engravings, etchings and lithographs) were the principal means of reproducing images. Prints disseminated imagery of Indigenous people and determined how they were 'put in th ....Graphic Encounters: Colonial Prints and the Inscription of Aboriginality. This project plans to collate the archive of prints depicting Indigenous Australians, from national and international collections, to ask how people's place in this newly encroached territory was inscribed by colonial prints. Before the 1890s, prints (engravings, etchings and lithographs) were the principal means of reproducing images. Prints disseminated imagery of Indigenous people and determined how they were 'put in the picture' of settlement. Our colonial-era cultural heritage includes many prints (engravings, etchings, lithographs, etcetera) of Aborigines, yet they have been overlooked and the story of their production, dissemination and consumption is untold. This project aims to collate and trace this visual archive of Indigenous Australians and present its imagery to all Australians, including descendants, in an exhibition and conference, catalogue, monograph and online database.Read moreRead less
Molecular hallmarks of androgen receptor targeting in prostate cancer. There is a critical need in oncology drug development for better biomarkers of response to prostate cancer therapies, clinically to assist with treatment decision making, and pre-clinically to facilitate translation of emerging agents into clinical practice. Using a unique explant culture model, this project will identify protein and lipid markers that can be used to accurately and reliably assess response to androgen recepto ....Molecular hallmarks of androgen receptor targeting in prostate cancer. There is a critical need in oncology drug development for better biomarkers of response to prostate cancer therapies, clinically to assist with treatment decision making, and pre-clinically to facilitate translation of emerging agents into clinical practice. Using a unique explant culture model, this project will identify protein and lipid markers that can be used to accurately and reliably assess response to androgen receptor (AR)-targeting therapies in human prostate tumours. The identification and functional assessment of these biomarkers will identify those that can be used as surrogate endpoints in clinical trials, facilitate earlier approval of investigational agents and lead to improved options for therapeutic management of prostate cancer.Read moreRead less
Evolution, adaptation and resilience of Australian freshwater fishes. This project will integrate comparative ecological genomics (in the wild and in the lab), phenotypic data and spatially-explicit modelling approaches to assess adaptation and vulnerability of aquatic biodiversity to environmental change. It focuses on a family of Australian freshwater fishes that evolved in response to hydrological disturbance and shows contemporary patterns of biodiversity shaped by hydroclimatic variation an ....Evolution, adaptation and resilience of Australian freshwater fishes. This project will integrate comparative ecological genomics (in the wild and in the lab), phenotypic data and spatially-explicit modelling approaches to assess adaptation and vulnerability of aquatic biodiversity to environmental change. It focuses on a family of Australian freshwater fishes that evolved in response to hydrological disturbance and shows contemporary patterns of biodiversity shaped by hydroclimatic variation and anthropogenic pressures. The project expects to disclose a positive correlation between family-wide adaptive capacity and variance in ecological disturbance. This work will address fundamental and novel questions about factors shaping adaptation and resilience along naturally and anthropogenically disturbed ecosystems.Read moreRead less
Resolving how five million years of dramatic climatic changes shaped Australia's unique fauna. Australia’s biota is a product of its unique heritage, tectonic history and most especially its climate. Over the past five million years it has been beset by a series of intense climatic shifts driven by a combination of global and regional factors. This project will be the first to track faunal responses to environmental changes across this critical interval. It will establish the dynamics of the ori ....Resolving how five million years of dramatic climatic changes shaped Australia's unique fauna. Australia’s biota is a product of its unique heritage, tectonic history and most especially its climate. Over the past five million years it has been beset by a series of intense climatic shifts driven by a combination of global and regional factors. This project will be the first to track faunal responses to environmental changes across this critical interval. It will establish the dynamics of the origin of the modern southern vertebrate fauna, analysing changes in diversity, diet and community structure. By exploring associations between phases of faunal turnover and key climatic transitions, it will bring a Southern Hemisphere perspective to evolutionary models of Cenozoic faunal change largely generated to date from Northern Hemisphere data.Read moreRead less
The Quest for Ultimate Measurement Precision. Precision measurement is the foundation upon which modern technological society is built. The highest quality measurement devices rely on stable clocks for their operation. The group's existing research has been aimed at developing some of the world's most precise measurement tools based on clocks and lasers. In parallel with this, other scientists have developed the means for exquisite control of light on the microscopic scale. By combining these tw ....The Quest for Ultimate Measurement Precision. Precision measurement is the foundation upon which modern technological society is built. The highest quality measurement devices rely on stable clocks for their operation. The group's existing research has been aimed at developing some of the world's most precise measurement tools based on clocks and lasers. In parallel with this, other scientists have developed the means for exquisite control of light on the microscopic scale. By combining these two technologies, both of which lie at the extreme limit of precision, the group will develop a new generation of technology for fundamental science objectives as well as for industrial needs.Read moreRead less
Discovering the pathways and mechanisms underlying bio-insecticide control of the global migratory pest, diamondback moth, Plutella xylostella. Sustaining crop yield and maintaining food security is a significant worldwide concern. This project aims to strengthen insect pest control strategies and improve bio-insecticide use in agriculture through better understanding of the mode of action of Bacillus thuringiensis (Bt) insecticides. It aims to improve their efficacy and evaluate opportunities t ....Discovering the pathways and mechanisms underlying bio-insecticide control of the global migratory pest, diamondback moth, Plutella xylostella. Sustaining crop yield and maintaining food security is a significant worldwide concern. This project aims to strengthen insect pest control strategies and improve bio-insecticide use in agriculture through better understanding of the mode of action of Bacillus thuringiensis (Bt) insecticides. It aims to improve their efficacy and evaluate opportunities to develop bio-insecticides based on plant saponins. This will assist in determining the risk of insecticide resistant moths migrating to Australia, and within our borders. This project aims to provide opportunities to improve transgenic Bt-crops and Bt-sprays, provide commercial development of new bio-insecticides, and develop optimal control strategies for major Australian migratory pests.Read moreRead less