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Biology Of EGFR Mutations In Glioblastoma Multiforme
Funder
National Health and Medical Research Council
Funding Amount
$287,445.00
Summary
The epidermal growth factor receptor (EGFR) is a protein that has a critical role in the development of normal cells. In glioma, the most lethal of the brain cancers, the EGFR is altered. These alterations result in uncontrolled activation of the EGFR, causing signals that promote the growth and survival of brain cancer. This grant seeks to understand the nature of the signals mediated by the altered EGFR, in turn helping us develop better therapeutics for the treatment of this deadly cancer.
New multi-scale seed dispersal models for improved regional weed management. This project will exploit recent advances in ecological and atmospheric modelling with the aim to build improved models of seed dispersal across landscapes to anticipate weed spread. Damaging invasive plants are rapidly transforming landscapes and altering ecosystem function worldwide. The speed and direction of weed spread determines the success or failure of costly containment and control actions, however we lack the ....New multi-scale seed dispersal models for improved regional weed management. This project will exploit recent advances in ecological and atmospheric modelling with the aim to build improved models of seed dispersal across landscapes to anticipate weed spread. Damaging invasive plants are rapidly transforming landscapes and altering ecosystem function worldwide. The speed and direction of weed spread determines the success or failure of costly containment and control actions, however we lack the ability to adequately predict spread. New models that combine micrometeorological measurements, within-canopy turbulence and topographic variation in wind flows will be designed to better predict where dispersal will occur. In this project, these improved predictions are planned to be combined with decision models to direct the management of invasive species across entire landscapes.Read moreRead less
An Integrated Systems Biology Approach For The Development Of New Therapeutic Strategies For The Treatment Of High Grade Glioma
Funder
National Health and Medical Research Council
Funding Amount
$696,404.00
Summary
Glioma, the most common adult brain cancer, is incurable. Recent advances now allow us to grow glioma cells directly from patients in the laboratory in a way that preserves the features of the original tumor. In this proposal we will systematically analyze such cells using state-of-the-art technologies to identify new processes important to glioma, which in turn should facilitate the identification of innovative therapeutic approaches.
Signalling Networks As Targets For Antibody Therapy In Glioma.
Funder
National Health and Medical Research Council
Funding Amount
$526,683.00
Summary
Antibodies are a major component of the bodies immune system that bind (i.e. stick) to foreign substances such as viruses. Once bound, these antibodies can activate other parts of the immune system, which help destroy the foreign substance. Analogous to the situation above, a number of institutions are testing antibodies that bind to cancer cells, in order to determine if they are able to destroy these cells. It is also possible to generate antibodies that bind to receptors on the surface of can ....Antibodies are a major component of the bodies immune system that bind (i.e. stick) to foreign substances such as viruses. Once bound, these antibodies can activate other parts of the immune system, which help destroy the foreign substance. Analogous to the situation above, a number of institutions are testing antibodies that bind to cancer cells, in order to determine if they are able to destroy these cells. It is also possible to generate antibodies that bind to receptors on the surface of cancer cells and block their function. If you target a receptor critical to the growth or survival of a cancer cell in this way, then swtiching-off this signal may inhibit tumor growth. In this proposal we plan to test a panel antibodies that recognize receptors important to the growth of brain cancer. Two of these antibodies have been generated and the other two will be made as part of this proposal. A key aspect of this proposal will be testing these antibodies in combination to determine how many receptors need to be targeted in order to get complete tumor regressions in animal models. Overall this work will help us identify new therapeutic strategies for the treatment of brain cancer. Finally, we will also analyze the way different receptors interact together in brain cancer cells.Read moreRead less
Mitigating extreme water supply contamination in bushfire burned catchments. This project involves Melbourne Water, the Department of Environment and Primary Industries, and East Gippsland Water in developing tools to evaluate mitigation options that will protect our water supplies and increase the resilience of Australian communities to bushfire. Major bushfires in south-east Australia in 2003, 2007, 2009 and 2013 were followed by storms that triggered extreme soil erosion events in catchments, ....Mitigating extreme water supply contamination in bushfire burned catchments. This project involves Melbourne Water, the Department of Environment and Primary Industries, and East Gippsland Water in developing tools to evaluate mitigation options that will protect our water supplies and increase the resilience of Australian communities to bushfire. Major bushfires in south-east Australia in 2003, 2007, 2009 and 2013 were followed by storms that triggered extreme soil erosion events in catchments, contaminating water supplies and damaging critical infrastructure. The capacity to mitigate the risk of interruption to the water supplies of our cities and towns in a more fire-prone future is currently limited by our knowledge of where, why, and how often these post-fire contamination events will occur. This project aims to address these knowledge gaps.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101611
Funder
Australian Research Council
Funding Amount
$379,040.00
Summary
Snow, shrub and climate feedbacks: impacts of shrub expansion in the Australian alpine zone. This project aims to understand the mechanisms promoting shrub expansion in alpine areas and the consequences of a shrub-dominated landscape in terms of shrubs as hydrological mediators and as biodiversity and ecosystem modifiers. Some shrub species trap wind-blown snow, thereby facilitating seedling survival through soil insulation and increases to meltwater. However, if adaptive and plastic responses t ....Snow, shrub and climate feedbacks: impacts of shrub expansion in the Australian alpine zone. This project aims to understand the mechanisms promoting shrub expansion in alpine areas and the consequences of a shrub-dominated landscape in terms of shrubs as hydrological mediators and as biodiversity and ecosystem modifiers. Some shrub species trap wind-blown snow, thereby facilitating seedling survival through soil insulation and increases to meltwater. However, if adaptive and plastic responses to climate change allows, shrub expansion will have significant negative impacts on alpine biodiversity and ecosystem function. This project will tease apart the interacting effects of snow, recruitment and adaptation to provide models of shrub increase and determine how shrubs modify alpine ecosystem processes and upper catchment hydrology.Read moreRead less
New High-risk Variants For Colorectal Cancer: The Post-GWAS Era
Funder
National Health and Medical Research Council
Funding Amount
$710,105.00
Summary
Our aim is to discover new genes that greatly increase bowel cancer risk. If we can identify these carriers we may be able to prevent them getting cancer. By studying DNA related to bowel cancer, using a novel family design, we will identify families most likely to carry the new genes. We will focus genetic testing, using new techniques, to look for mutations in these prioritised families. Identified mutations will be tested in a 3,500 bowel cancer cases to see how important they are.
Suppression Of NADPH Oxidase-derived Oxidative Stress By Anti-sense Probes And HDL In Human Vascular Endothelium
Funder
National Health and Medical Research Council
Funding Amount
$455,250.00
Summary
In Australia, coronary heart disease (CHD) causing heart attacks remains the largest cause of death, claiming a staggering 28,000 lives a year. Oxidative stress, resulting from increased production of oxygen free radicals in arteries, is an important cause of CHD, heart attacks and strokes. We seek to understand how such oxyradicals are produced in the key cells that form the lining of all arteries, known as the vascular endothelium. By using novel DNA-type molecules (known as anti-sense) develo ....In Australia, coronary heart disease (CHD) causing heart attacks remains the largest cause of death, claiming a staggering 28,000 lives a year. Oxidative stress, resulting from increased production of oxygen free radicals in arteries, is an important cause of CHD, heart attacks and strokes. We seek to understand how such oxyradicals are produced in the key cells that form the lining of all arteries, known as the vascular endothelium. By using novel DNA-type molecules (known as anti-sense) developed in our laboratory, which block a particular gene causing oxidative stress, we will determine whether this gene is responsible for the formation of oxyradicals in human and mouse cells grown in culture. In addition, we will explore whether this gene is turned on by factors known to be involved in CHD. Finally, we will also investigate whether the good cholesterol known as HDL can act to prevent oxidative stress in human cells, as we discovered it appears to do in living arteries in vivo. If we find it has the same protective effect in endothelium, we will determine how it does this, and which component proteins of the HDL particle are important. This might suggest new treatments to prevent acute events leading to heart attack and stroke, and possibly new applications where damage appears to result from acute oxidative stress, such as in the brain soon after a stroke has occurred. We also have a plan to develop antisense drugs that will target the important gene specifically in the affected endothelium. In addition, we have other specific new drugs that will block this system in arteries. Simultaneously we will be testing the role of this gene in mouse and rabbit models of artery disease, for both our types of drugs might provide valuable new therapeutic agents to target the underlying cause of CHD and not just its symptoms as current drugs do.Read moreRead less
The origin of (dark) matter. This project aims to discover the origin and nature of dark matter and why the Universe contains more matter than antimatter – two important unresolved problems in particle physics and cosmology. These questions cannot be resolved within the framework of the particle physics Standard Model, and thus provide concrete evidence that new elementary particle physics remains to be uncovered. This project aims to explore the origin of dark matter, new mechanisms for creatin ....The origin of (dark) matter. This project aims to discover the origin and nature of dark matter and why the Universe contains more matter than antimatter – two important unresolved problems in particle physics and cosmology. These questions cannot be resolved within the framework of the particle physics Standard Model, and thus provide concrete evidence that new elementary particle physics remains to be uncovered. This project aims to explore the origin of dark matter, new mechanisms for creating a matter-antimatter asymmetry, and the possibility that dark and ordinary matter share a common origin. This project could address humanity's deep need to understand the nature of the universe and our origins.Read moreRead less