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New multi-scale seed dispersal models for improved regional weed management. This project will exploit recent advances in ecological and atmospheric modelling with the aim to build improved models of seed dispersal across landscapes to anticipate weed spread. Damaging invasive plants are rapidly transforming landscapes and altering ecosystem function worldwide. The speed and direction of weed spread determines the success or failure of costly containment and control actions, however we lack the ....New multi-scale seed dispersal models for improved regional weed management. This project will exploit recent advances in ecological and atmospheric modelling with the aim to build improved models of seed dispersal across landscapes to anticipate weed spread. Damaging invasive plants are rapidly transforming landscapes and altering ecosystem function worldwide. The speed and direction of weed spread determines the success or failure of costly containment and control actions, however we lack the ability to adequately predict spread. New models that combine micrometeorological measurements, within-canopy turbulence and topographic variation in wind flows will be designed to better predict where dispersal will occur. In this project, these improved predictions are planned to be combined with decision models to direct the management of invasive species across entire landscapes.Read moreRead less
Signalling Networks As Targets For Antibody Therapy In Glioma.
Funder
National Health and Medical Research Council
Funding Amount
$526,683.00
Summary
Antibodies are a major component of the bodies immune system that bind (i.e. stick) to foreign substances such as viruses. Once bound, these antibodies can activate other parts of the immune system, which help destroy the foreign substance. Analogous to the situation above, a number of institutions are testing antibodies that bind to cancer cells, in order to determine if they are able to destroy these cells. It is also possible to generate antibodies that bind to receptors on the surface of can ....Antibodies are a major component of the bodies immune system that bind (i.e. stick) to foreign substances such as viruses. Once bound, these antibodies can activate other parts of the immune system, which help destroy the foreign substance. Analogous to the situation above, a number of institutions are testing antibodies that bind to cancer cells, in order to determine if they are able to destroy these cells. It is also possible to generate antibodies that bind to receptors on the surface of cancer cells and block their function. If you target a receptor critical to the growth or survival of a cancer cell in this way, then swtiching-off this signal may inhibit tumor growth. In this proposal we plan to test a panel antibodies that recognize receptors important to the growth of brain cancer. Two of these antibodies have been generated and the other two will be made as part of this proposal. A key aspect of this proposal will be testing these antibodies in combination to determine how many receptors need to be targeted in order to get complete tumor regressions in animal models. Overall this work will help us identify new therapeutic strategies for the treatment of brain cancer. Finally, we will also analyze the way different receptors interact together in brain cancer cells.Read moreRead less
How does orography enhance precipitation in Australian wintertime storms? This project aims to employ targeted field observations, numerical simulations and new satellite capabilities to identify the dynamical and microphysical mechanisms that enhance and redistribute precipitation across the alpine regions of south eastern Australia and Tasmania. These observations will be used to evaluate operational numerical weather simulations specifically focusing on quantitative precipitation forecasts an ....How does orography enhance precipitation in Australian wintertime storms? This project aims to employ targeted field observations, numerical simulations and new satellite capabilities to identify the dynamical and microphysical mechanisms that enhance and redistribute precipitation across the alpine regions of south eastern Australia and Tasmania. These observations will be used to evaluate operational numerical weather simulations specifically focusing on quantitative precipitation forecasts and estimates. The observations will also be used to extend known biases in the national gridded precipitation analysis that are a result of the complex mountain terrain. This identification of the physical processes that enhance and redistribute precipitation over the alpine regions across south east Australia and Tasmania will lead to better precipitation estimates and forecasts and better water management.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100158
Funder
Australian Research Council
Funding Amount
$750,000.00
Summary
The Nanten2 sub-millimetre telescope. The millimetre-wavelength sky holds the key for understanding how stars form in the coldest regions of interstellar space: the molecular clouds of our Galaxy. A new frontline facility in Chile will be used in an international research endeavour to map their structures, in order to find out how they form and what causes stars to be born inside them.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100038
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
The NANTEN2 Observatory sub-millimetre wave telescope. The millimetre-wavelength sky holds the key to understanding how stars form in the coldest regions of interstellar space: the molecular clouds of our Galaxy. This new frontline facility in Chile will be used in an international research endeavour to map these cold regions and the stars they contain in order to find out how they form and what causes stars to be born within them.