Clinical Utility And Cost-effectiveness Of Genome Sequencing For Refractory Epilepsy In Children And Adults: A Multicentre Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$720,609.00
Summary
A large number of genomic variants have been found to underpin common types of epilepsy and to predict adverse drug reactions. However, the adoption of genomic testing in the routine management of epilepsy is hampered by uncertainties around its clinical utility and cost-effectiveness. This randomised controlled trial aims to determine the diagnostic efficiency, clinical and psychosocial impact, and cost-effectiveness of whole genome sequencing for refractory epilepsy in children and adults.
Selective Targeting Of Adjuvant Therapy For Endometrial Cancer: The STATEC Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,239,309.00
Summary
This international collaborative trial for women with aggressive endometrial cancer will investigate whether lymph node removal (lymphadenectomy) at time of hysterectomy is needed to predict whether patients need additional treatment, compared to not removing the lymph nodes and giving additional treatment to all such patients. If we can select patients who need further treatment more accurately, we will avoid giving patients unnecessary toxic treatment which impacts on their quality of life.
An Empirical Framework For Assessing Mortality And Morbidity In People With Psychotic Disorders: A 7-year Prospective And 10-year Retrospective Follow-up Of 2075 Participants In The Survey Of High Impact Psychosis (SHIP) Using Linked Registers
Funder
National Health and Medical Research Council
Funding Amount
$751,876.00
Summary
Our study is designed to fill a knowledge gap on mortality and morbidity in people with a psychotic disorder. It will: 1. Estimate rates of 7-year mortality and morbidity in people with a psychotic disorder. 2. Examine the impact of sets of risk factors on mortality and morbidity. 3. Develop predictive risk equations for CVD for use with people with psychotic disorders. 4. Calculate the economic burden of severe and acute physical morbidity in addition to mental health impacts.?
Costing The Place Of Birth In NSW: New Knowledge To Support Maternity Service Reform
Funder
National Health and Medical Research Council
Funding Amount
$269,478.00
Summary
The comparative costs of giving birth at home, in a birth centre or in a hospital labour ward is unknown. This study will build on the current Birthplace in Australia Study to provide much needed evidence to inform policy and health service allocation decisions in Australian maternity care.
A Novel Multi-gene Marker Blood Test To Increase Community Participation In Colorectal Cancer Screening.
Funder
National Health and Medical Research Council
Funding Amount
$581,116.00
Summary
Bowel cancer screening programs are vital for early detection and prevention, but participation with the traditional faecal testing mode is less than 35%. Reasons include dislike or unsuitability for faecal testing. These barriers could be overcome and participation could increase using a different sampling mode for the screening test. We have developed a blood test for bowel cancer and will investigate if people who will not screen with the stool test will screen with the blood test instead.
Building An Evidence Base For Funding Evidence-based Medicine
Funder
National Health and Medical Research Council
Funding Amount
$316,338.00
Summary
Funding schemes should be subject to the same scientific scrutiny as the proposals they scrutinize. If funding schemes could be improved, and higher quality proposals funded more reliably, then evidence-based medicine throughout Australia could be improved. Current evidence shows a concerning variability in funding decisions. We will examine the costs and reliability of the Project Grant scheme and two cheaper alternatives. Any savings we find could be re-invested back into medical research.
Biological, Phenotypic And Public Health Costs Of Risk And Protective Pathways To Non-communicable Disease In Children And Adults: The National Longitudinal Study Of Australian Children
Funder
National Health and Medical Research Council
Funding Amount
$1,521,590.00
Summary
Although a late event for most Australians, chronic diseases present a crippling burden for Australia. This project explores their early roots, before overt disease emerges, in 3500 parents and their children in the Longitudinal Study of Australian Children. We will measure how accumulated stress and buffering characteristics play out in the biology of cell ageing and inflammation, in developing heart, lung, kidney and bone health, and in quality of life and health costs to the population.
Health And Social Consequences Of Child Abuse And Neglect: An Analysis Using South Australian Linked Data
Funder
National Health and Medical Research Council
Funding Amount
$684,447.00
Summary
Child maltreatment can result in a range of poor health, social and economic outcomes. Current surveys tell us little about the size of these impacts for young people especially for those with the worst outcomes—death, homelessness, hospitalisation, incarceration. This study will use data from hospitals, child protection and other services to explore the impacts of maltreatment on young people in SA and related costs to government, to inform policy to improve outcomes for this vulnerable group.
Optimizing The Allocation Of Resources In Response To HIV/AIDS Epidemics
Funder
National Health and Medical Research Council
Funding Amount
$724,439.00
Summary
HIV/AIDS is still a major problem around the world, particularly in low- and middle-income countries. This project will support efforts to maximize health impact with limited resources, providing Ministries of Finance and Ministries of Health in developing countries along with global health agencies and funders a key tool and evidence on how to identify the optimal allocation of resources across multiple programs targeting numerous population groups.
Can Shoe Inserts Reduce The Burden Of Kneecap Osteoarthritis?
Funder
National Health and Medical Research Council
Funding Amount
$644,550.00
Summary
Kneecap arthritis is a leading cause of pain, disability and health expenditure in the Australian community. ‘Off-the-shelf’ shoe inserts are simple, low-cost devices that can reduce kneecap pain in young adults, and are accessible to all Australians. This project investigates whether ‘off-the-shelf’ shoe inserts improve pain in older adults with kneecap arthritis over 12 months, and evaluates the relationship between cost and patient benefits.