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Regulation Of Nucleocytoplasmic Transport; Role In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$823,008.00
Summary
Transport into and out of the nucleus is central to the function of the cells from complex organisms such as mammals. This research program aims to improve understanding of nuclear transport and its regulation in the context of infection by medically relevant viruses, as well as in the context of cancer, and normal cell growth/development. It will contribute to developing new anti-viral therapeutics/vaccines, drug delivery strategies for cancer, and understanding causes of male infertility.
A Proteome-wide Approach To Anti-viral Immunity And Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$622,655.00
Summary
We know that many parts of viruses are displayed to the immune system, but at present the exact fragments are difficult to predict, we do not know all the genes in our bodies that control this process and we also need better methods to study the way some viruses (e.g. the cold sore virus) avoid detection. This project will study these problems with the overall goal of improving vaccine design, understanding immune deficiency and how viruses fight back against our immune system.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.