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Detection, Prevention And Treatment Of Failure Of The Fontan Circulation
Funder
National Health and Medical Research Council
Funding Amount
$90,533.00
Summary
Children born with complex heart defects and only one pumping chamber can now live into adulthood with an operation called the Fontan procedure. As this operation has only existed for 40 years, the long-term expectations for these children and young adults are still unclear, and their population is growing every year. This project aims to answer questions about the follow-up and medical management of people living with a Fontan procedure.
Establishing The Intrinsic Regenerative Capacity Of The Adult Human Heart In Health And Disease And The Use Of Recombinant Cellular Growth Factors To Reverse Heart Failure In Vitro
Funder
National Health and Medical Research Council
Funding Amount
$110,615.00
Summary
Heart failure is a major cause of morbidity and mortality in Australia. We hope to change this bleak outlook by showing that the human heart can regenerate, thereby challenging the long-held dogma that our heart cannot regrow. Using human heart samples we will measure the intrinsic capability of these cells to regenerate in heart failure compared to what occurs in normal, healthy ageing. In addition, we will explore the use of extracellular growth factors to stimulate these heart muscle cells
Molecular And Structural Determinants Of Myocardial Dysfunction And Prognosis In Left And Right Heart Failure.
Funder
National Health and Medical Research Council
Funding Amount
$124,608.00
Summary
The aim of this research is to investigate the role of inherited genetic variation on myocardial function and prognosis in patients with cardiomyopathies as well as pulmonary hypertension. Clinical, cardiac genomic and myocardial tissue studies will be undertaken in various patient cohorts. It is hoped that this research will provide new insights into disease mechanisms, and will contribute to new approaches to patient management and risk stratification.
Cardiovascular disease is the leading cause of death in Australia. Aliskiren is the first renin inhibitor-type drug to be approved for clinical use for treatment of hypertension. The aim of this project is to evaluate the effectiveness of aliskiren for the treatment of heart attack and heart failure, as compared to existing therapies. Aliskiren may potentially replace or complement current therapies, thereby reducing death and improving health and economic benefits for the community.
Outcomes Of The Arterial Switch Operation: A Multi-centre Study
Funder
National Health and Medical Research Council
Funding Amount
$86,733.00
Summary
The arterial switch operation is the surgery of choice for children born with transposition of the great arteries, a congenital heart defect where the main two vessels of the heart arise from wrong pumping chambers of the heart. There are very few studies looking at adults after this operation. We aim to study all patients who have had an arterial switch. The results of this study will further increase our knowledge of the long term consequences of having the arterial switch operation.
Congenital aortic stenosis is a life-long condition caused by a narrowing of the aortic valve. It accounts for 2-6% of congenital heart disease, and if left untreated, results in heart failure and death. While several surgical and non-surgical interventions are available, the ideal treatment for this condition is unclear. My research aims to evaluate outcomes of aortic valve repair and compare it to other techniques.
Advanced Heart Failure Management With Ventricular Assist Therapy – Evaluating Australian Costs Of Care And Effectiveness From Implant To Transplant Or End Of Life
Funder
National Health and Medical Research Council
Funding Amount
$45,668.00
Summary
Ventricular Assist Devices (VADs) are implantable heart pumps that are increasingly being used to slow down the progression of end stage heart failure. This project assesses the costs and effectiveness of VAD therapy and advanced heart failure medical management in an Australian health care setting. The aim is to provide Australian clinicians and health decision makers access to current and relevant, clinical, cost and effectiveness data for advanced heart failure and VAD therapy.
Novel Cardiac Imaging Modalities And Biomarkers In Acute Decompensated Heart Failure.
Funder
National Health and Medical Research Council
Funding Amount
$100,926.00
Summary
Heart failure (an inability of the heart to meet the bodyÍs metabolic requirements) is a major public health burden with high rates of death, hospitalisation, and reduced quality of life. Further research is required to investigate the underlying mechanisms. This project will analyse abnormalities in heart structure and function using new techniques in heart ultrasound and magnetic resonance imaging, and blood tests. Findings in this study may help to guide the development of future therapies to ....Heart failure (an inability of the heart to meet the bodyÍs metabolic requirements) is a major public health burden with high rates of death, hospitalisation, and reduced quality of life. Further research is required to investigate the underlying mechanisms. This project will analyse abnormalities in heart structure and function using new techniques in heart ultrasound and magnetic resonance imaging, and blood tests. Findings in this study may help to guide the development of future therapies to improve outcomes in patients with heart failure.Read moreRead less