Guaranteeing Survival Into Adulthood, Physical Health And Psychological Well-being To Children Born With Single Ventricles.
Funder
National Health and Medical Research Council
Funding Amount
$342,773.00
Summary
Being born with a single pumping heart chamber is the most severe heart condition but thanks to several operations we can see them survive. A growing population of young functional adults now face an uncertain future and we have no options for them. A/Pr Y d’Udekem is a leading paediatric cardiac surgeon. His research aims to provide the medications, reinterventions and artificial hearts that are necessary to give them a longer and fulfilling life.
From Fundamental Mechanistic Discoveries To Strategic Methods For Early Detection And Treatment Of Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$412,419.00
Summary
I am an interventional cardiologist whose research program spans from biomedical discovery, to new markers of early cardiovascular disease and clinical trials of new therapy. We are particularly focused on novel strategies to help patients who suffer from heart attack despite having no standard risk factors. I lead a team of cross-disciplinary researchers. A Practitioner Fellowship will help me to achieve international impact against the leading cause of death and disability in our community.
New Approaches To The Management Of Atrial Fibrillation
Funder
National Health and Medical Research Council
Funding Amount
$577,189.00
Summary
Atrial fibrillation is the most common heart rhythm disorders and is now a common cause of hospitalisation in Australia. It can lead to devastating complications such as stroke and heart failure. This fellowship will under take a series of randomised studies to define new therapeutic strategies for management of atrial fibrillation. It aims to establish lifestyle and preventative measures into the mainstream for the management and prevention of this condition.
Atrial fibrillation (AF) has reached epidemic proportions. It results in significant burden to the individual and community with palpitations, falls, strokes, and heart failure which have contributed to an exponential rise in health care usage and hospitalisation. This application will focus on the optimal management of AF with a focus not only on therapeutics but importantly on the prevention of the arrhythmia and minimising hospitalisation.
Better Care Of Heart And Lung Disease For Aboriginal And Torres Strait Islander People In Rural And Remote Australia
Funder
National Health and Medical Research Council
Funding Amount
$380,583.00
Summary
Lung and heart disease are major contributors to the Aboriginal Australian and Torres Strait Islander health gap. This is even more so in remote and regional Australia. This Fellowship will generate new knowledge regarding how best to prevent, diagnose and treat heart and lung disease in this setting. Based in Alice Springs, it will bring together researchers and health care providers across northern and Central Australia and link them with our leading national research institutes.
Development Of Systemic Therapies To Improve Response And Prevent Resistance In The Treatment Of Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$569,219.00
Summary
This program of research utilises the unique resources at Melanoma Institute Australia (MIA) to understand the biology of prolonged response and resistance to novel drug therapies used in metastatic melanoma, a cancer that now leads the field in the discovery of new targets for therapeutic manipulation. This program also aims to create new methods to efficiently test and develop drug therapy combinations in humans to improve patient outcomes further or prevent metastatic melanoma altogether.
I am an orthopaedic surgeon and clinician-scientist based at Sydney’s largest children’s hospital. My goal is to improve treatments for children with traumatic injuries and bone deformity. I have worked in bone research for over 20 years. My current research interests are finding new treatments for drug-resistant bacterial infections, treating genetic bone disease, and developing new medical devices to help children’s bones grow straight.
Neurobiology Of Childhood Speech And Language Disorders: Advancing Diagnosis, Prognosis And Management
Funder
National Health and Medical Research Council
Funding Amount
$467,961.00
Summary
Half a million Australian children have a speech/language disorder, tripling their changes of poor academic outcomes, limited employment options and social isolation. Current speech therapy is outdated, focusing on symptoms and ignoring important evidence on underlying aetiologies. I will transform detection, diagnosis and treatment of speech/language disorders to optimise patient outcomes, by identifying and translating findings on genes and brain pathways leading to these conditions.
Major advances in cancer treatment has been made by identifying gene mutations in cancers to which the cancer is “addicted”, such that turning off the effects of the mutations leads to death of the cancer cells. Grant McArthur has been successful in applying this principle to rare types of sarcoma bringing his work to routine clinical practice globally. In this application he will investigate targeting the BRAF, KIT and MYC genes focusing on melanoma, a major cancer problem in Australia.
Immunopathogenesis And Manipulation Of The HIV Reservoir
Funder
National Health and Medical Research Council
Funding Amount
$494,732.00
Summary
Kelleher is a Clinical immunologist with a globally recognised, sustained track record of translational research which has impacted both on our understanding of HIV immunopathogenesis and on the way HIV infection is treated. He will conduct a series of studies that encompass basic scientific techniques through to pivotal pre-clinical and clinical studies that will provide a pathway towards control of HIV-infection without daily therapy.