Finding New Evidence Based Therapies For Treating Heart Disease And Stimulating Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$11,088,182.00
Summary
Heart disease is the leading cause of death and disability in our society. This interactive team of clinicians and basic scientists will exploit the latest advances in genome technology and stem cell biology to gain greater insights into the genetic basis of heart disease, elucidate the molecular mechanisms of cardiac function and disease and translate these insights into the development of novel therapeutic approaches for the prevention and treatment of heart disease.
A PROGRAM OF TRANSLATIONAL CARDIOVASCULAR MEDICINE: IDENTIFYING NEW TARGETS FOR PREVENTION AND TREATMENT
Funder
National Health and Medical Research Council
Funding Amount
$13,050,773.00
Summary
Cardiovascular disease (CVD) is the major cause of death and disability in Australia and worldwide, despite signficant advances in treatment. Our team has an international reputation for developing innovative approaches for the treatment of patients with CVD. We will work collaboratively to improve outcomes for people suffering from hypertension, heart attack, heart failure & other serious forms of CVD.
Novel Approaches To The Prevention And Treatment Of Chronic Heart Disease And Its Co-morbid Complications
Funder
National Health and Medical Research Council
Funding Amount
$5,793,580.00
Summary
Cardiovascular disease (CVD) and its associated additional disorders constitute major public health problems, especially given the rapidly ageing population which is increasingly affected by obesity and diabetes. This Program will explore novel therapies for the treatment of CVD and associated diseases, particularly focussing on chronic kidney disease, translating preliminary laboratory-based findings into clinical trials and then clinical and epidemiological findings into practice and policy.
ADVANCING THE EVIDENCE BASE FOR CARE AND POLICY IN PRIORITY HEALTH AREAS
Funder
National Health and Medical Research Council
Funding Amount
$11,195,727.00
Summary
This program will improve health care and policy through clinical trials research and better methods for combining trial evidence. The team will tackle priority health areas to reduce death and serious disability: in particular in cancer, cardiovascular disease, diabetes, obesity and neonatal diseases. The program team includes clinicians, epidemiologists, trialists, biostatisticians, and health economists and collaborative networks of clinical investigators in each disease area.
Disorders Of Sex Development: Genetics, Diagnosis, Informing Clinical Care
Funder
National Health and Medical Research Council
Funding Amount
$5,751,502.00
Summary
Disorders of sexual development (DSDs) are surprisingly common, and often result in genital abnormalities, gender mis-assignment, infertility and psychological trauma. We will pool our expertise in human genetics, molecular and developmental biology, to find genes important for sex development, identify gene defects that cause DSD, and study their functions. We will liaise with clinicians to apply these findings to the accurate diagnosis and medical care of DSD in children.
From Discovery To Innovation In Stuttering Treatment
Funder
National Health and Medical Research Council
Funding Amount
$5,124,148.00
Summary
Stuttering starts in 2-3-year olds and if not controlled causes a lifetime of social anxiety, and hinders educational and vocational achievement. Recent discoveries by the current team and colleagues have shown the disorder to be far more prevalent, and more of a public health problem, than previously thought. The team has developed efficacious treatments for stuttering children and adults. However, no country can afford the health care needed for all who stutter. The present research is designe ....Stuttering starts in 2-3-year olds and if not controlled causes a lifetime of social anxiety, and hinders educational and vocational achievement. Recent discoveries by the current team and colleagues have shown the disorder to be far more prevalent, and more of a public health problem, than previously thought. The team has developed efficacious treatments for stuttering children and adults. However, no country can afford the health care needed for all who stutter. The present research is designed to solve this problem by developing standalone Internet based stuttering treatments. These will be evaluated in a stepped care treatment approach for people who stutter, in Australia and internationally.Read moreRead less
Tropical Disease - Immunity, Pathogenesis And Vaccine Development: Global Translation
Funder
National Health and Medical Research Council
Funding Amount
$17,988,456.00
Summary
Tropical diseases create a significant human and economic burden worldwide - particularly in resource-poor settings. Around half of the world's population is at risk of malaria. In Australia, Streptococcal and parasitic worm infections are particularly common in indigenous communities. This Program brings together leading experts to tackle these major health challenges. They are investigating how the body reacts to infection and creating new drugs and vaccines to eradicate these diseases.
The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in communities worldwide. We have assembled a research team of seven groups who will determine the ways in which the effects of influenza can be mitigated through an understanding of the factors which lead to severe disease, and how these can be lessened by novel vaccination and treatment strategies.