Understanding how reproduction and sexual conflict drive sex-dependent longevity and ageing. The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how molecules, genes, hormones, tissues and cells interact during ageing. The evolutionary study of ageing is considered one of the success stories of the emerging field of evolutionary medicine, yet we desperately need greater integration of the evol ....Understanding how reproduction and sexual conflict drive sex-dependent longevity and ageing. The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how molecules, genes, hormones, tissues and cells interact during ageing. The evolutionary study of ageing is considered one of the success stories of the emerging field of evolutionary medicine, yet we desperately need greater integration of the evolutionary and mechanistic spheres. This project addresses why males and females have different lifespans and age differently in a way that bridges evolutionary and mechanistic study, and will build Australia's research capacity to study ageing at both levels. Read moreRead less
Gas phase studies of reactive organic radicals: a novel approach using mass spectrometry. Radical reactions play a crucial role in a range of important chemistries, ranging from the formation of photochemical smog to the accumulation of pathogens in the ageing body. Despite their importance, the reactions of many radicals are poorly understood because of current experimental limitations. In this project we propose to develop two new and broadly applicable techniques for probing radical chemistry ....Gas phase studies of reactive organic radicals: a novel approach using mass spectrometry. Radical reactions play a crucial role in a range of important chemistries, ranging from the formation of photochemical smog to the accumulation of pathogens in the ageing body. Despite their importance, the reactions of many radicals are poorly understood because of current experimental limitations. In this project we propose to develop two new and broadly applicable techniques for probing radical chemistry in the gas phase via novel applications of mass spectrometry. Combined with quantum chemical calculations and state-of-the-art thermodynamic measurements these methods will provide a comprehensive understanding of the reactivity of key organic radicals.Read moreRead less
Why do good males die young? The relationship between ageing and sexual selection. A biological understanding of ageing is directly relevant to human welfare. We will use lab and field studies to explore the evolutionary genetics of ageing in an Australian cricket, with particular emphasis on how diet and the timing of reproduction influence the rate at which crickets deteriorate with age. We will also test whether biological differences between males and females generate genetic conflicts over ....Why do good males die young? The relationship between ageing and sexual selection. A biological understanding of ageing is directly relevant to human welfare. We will use lab and field studies to explore the evolutionary genetics of ageing in an Australian cricket, with particular emphasis on how diet and the timing of reproduction influence the rate at which crickets deteriorate with age. We will also test whether biological differences between males and females generate genetic conflicts over ageing rates. Our results will not only complement an evolutionary study of ageing, but may ultimately suggest interventions that may prolong human life or improve the quality of life in an ageing population.Read moreRead less
Linking the evolutionary and bioenergetic causes of sex differences in lifespan and ageing. The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how genes, hormones, tissues and cells interact during ageing. Interventions to prolong longevity and improve quality of life depend on a vigorous and innovative research effort in both spheres. This project addresses why males and females have differe ....Linking the evolutionary and bioenergetic causes of sex differences in lifespan and ageing. The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how genes, hormones, tissues and cells interact during ageing. Interventions to prolong longevity and improve quality of life depend on a vigorous and innovative research effort in both spheres. This project addresses why males and females have different lifespans and age differently in a way that bridges evolutionary and mechanistic study, and will build Australia's research capacity to study ageing at both levels. Because of the human interest in diet, sex, reproduction and ageing, we expect this research will be a showcase for public interest in science.Read moreRead less
The role of sexual conflict in the evolution of lifespan and ageing. Despite the central importance of ageing in our own lives, our understanding of the evolution of ageing is still incomplete. Reproductive interests of males and females often diverge, resulting in sexual conflict which may in turn drive the evolution of rapid ageing. I will use experimental evolution to investigate the role of sexual conflict in the evolution of age-specific mortality, reproductive ageing and lifespan in the se ....The role of sexual conflict in the evolution of lifespan and ageing. Despite the central importance of ageing in our own lives, our understanding of the evolution of ageing is still incomplete. Reproductive interests of males and females often diverge, resulting in sexual conflict which may in turn drive the evolution of rapid ageing. I will use experimental evolution to investigate the role of sexual conflict in the evolution of age-specific mortality, reproductive ageing and lifespan in the seed beetle Callosobruchus maculates. This study will reveal the role of sexual interactions and reproduction in the ageing process and result in the development of important new resources for resolving the genetic basis of deteriorative ageing.Read moreRead less
Preventing Suicide: A psychological autopsy study of the last contact with a health professional before suicide. In Australia, 48% of all suicides in 2000 were by 35-64 year olds; an additional 13% were by 65 years and over. This study will examine the last clinical contact older suicide victims had with health professionals in order to determine whether this contact offers an opportunity for intervention. For the first time in Australia, GP's, health professionals, and the deceased's next-of-ki ....Preventing Suicide: A psychological autopsy study of the last contact with a health professional before suicide. In Australia, 48% of all suicides in 2000 were by 35-64 year olds; an additional 13% were by 65 years and over. This study will examine the last clinical contact older suicide victims had with health professionals in order to determine whether this contact offers an opportunity for intervention. For the first time in Australia, GP's, health professionals, and the deceased's next-of-kin will be interviewed to determine the context surrounding the deceased's death, and the abilities of health professionals to identify warning signs and to intervene prior to suicide. Given our ageing population, the outcomes will be significant in educating all health professionals to identify suicidal signs, and to prevent premature death in the elderly.Read moreRead less
Changing Places: An exploration of factors influencing the move of older people from retirement villages to residential aged care. Older Australians living in retirement villages, an increasing community population segment, make choices both about the place at which they live, and the support needed to optimise health and wellbeing at that place. Changing places for this group often involves moving from retirement village to residential aged care facility. This study explores how and why this ....Changing Places: An exploration of factors influencing the move of older people from retirement villages to residential aged care. Older Australians living in retirement villages, an increasing community population segment, make choices both about the place at which they live, and the support needed to optimise health and wellbeing at that place. Changing places for this group often involves moving from retirement village to residential aged care facility. This study explores how and why this change occurs, how it might be avoided, and, when the move is unavoidable what can improve the moving process. Findings will inform innovations in policy, service and health care provision designed to facilitate appropriate ageing in place congruent with best practice principles.Read moreRead less
Special Research Initiatives - Grant ID: SR0354827
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
HEALTHY AGEING - PREVENTION AND INTERVENTION (HA-PI) NETWORK:
A RESEARCH NETWORK PROPOSAL ON THE BIOLOGICAL, SOCIAL AND PRIMARY CARE DYNAMICS OF AGEING
. Australian ageing research is dispersed across bioscience, social science and primary care organisations. Advances in healthy, productive ageing require connection of these three vital links. Bioscience and social science groupings are engaged in generating the evidence that primary care experts need to promote healthy ageing. Primary ....HEALTHY AGEING - PREVENTION AND INTERVENTION (HA-PI) NETWORK:
A RESEARCH NETWORK PROPOSAL ON THE BIOLOGICAL, SOCIAL AND PRIMARY CARE DYNAMICS OF AGEING
. Australian ageing research is dispersed across bioscience, social science and primary care organisations. Advances in healthy, productive ageing require connection of these three vital links. Bioscience and social science groupings are engaged in generating the evidence that primary care experts need to promote healthy ageing. Primary care experts also need to act as ?direction finders? for research on ageing so that the right questions are addressed. All these groups are relatively under-funded and poorly connected. The HA-PI Network will connect and support them to over-come barriers to the implementation of existing research and to create innovations for the future.Read moreRead less
Alone in a crowd: Supporting older Australians managing loneliness. The project provides crucial understandings and knowledge about loneliness as understood by older Australians and support/service providers, and solutions to assist them manage it. The findings will provide immediate practical outcomes that can be implemented by support/service providers, whilst also providing information that can assist policy makers and managers in the service provision area. The findings will enhance the heal ....Alone in a crowd: Supporting older Australians managing loneliness. The project provides crucial understandings and knowledge about loneliness as understood by older Australians and support/service providers, and solutions to assist them manage it. The findings will provide immediate practical outcomes that can be implemented by support/service providers, whilst also providing information that can assist policy makers and managers in the service provision area. The findings will enhance the health and well-being of older Australians with concomitant social and economic benefits. The study contributes to ensuring the optimum use and deployment of finite health and social resources.Read moreRead less
Options, Opportunities and Older people: An exploration of care transitions of older people. Older Australians experience transition points in type and level of support needed to age in their place of choice. Transition points refer to some form of destabilisation in the life of the older person resulting in a changed level of care required along the continuum of care options and opportunities available. This multi-stage, multi-State, qualitative study will determine what constitutes a 'good t ....Options, Opportunities and Older people: An exploration of care transitions of older people. Older Australians experience transition points in type and level of support needed to age in their place of choice. Transition points refer to some form of destabilisation in the life of the older person resulting in a changed level of care required along the continuum of care options and opportunities available. This multi-stage, multi-State, qualitative study will determine what constitutes a 'good transition' for older people, how 'transition points' are identified by consumers and service providers, and what happens after such identification. The study contributes to prevention and early intervention responses enabling older people to age in place wherever possible.Read moreRead less