Conformationally constrained and immobilized beta-peptides. The research builds on world-class expertise in Australia (particularly Adelaide) in proteomics to provide a basis for fundamental advances in chemistry that will underpin the development of new pharmaceuticals and smart materials, and future technologies and industries. We create a mix of research at the interface of disciplines within academia and industry, with linkages to the very best international researchers and centres. A new cr ....Conformationally constrained and immobilized beta-peptides. The research builds on world-class expertise in Australia (particularly Adelaide) in proteomics to provide a basis for fundamental advances in chemistry that will underpin the development of new pharmaceuticals and smart materials, and future technologies and industries. We create a mix of research at the interface of disciplines within academia and industry, with linkages to the very best international researchers and centres. A new critical mass of expertise in a number of advancing areas of chemistry, biology, and materials science will be introduced to Australia. This will enhance existing strengths and opportunities in proteomics and biomedical research for the treatment of disease.Read moreRead less
New clean and green aqueous metathesis. The technique of olefin metathesis has already yielded new pharmaceuticals and materials for use in consumer products and ballistic protection. This project will help move metathesis into the realms of natures aqueous environment, a key advance if metathesis is to reveal its full potential in biological, polymeric, and pharmaceutical applications. We specifically aim to target treatments for cataract (and other conditions associated with an aging populatio ....New clean and green aqueous metathesis. The technique of olefin metathesis has already yielded new pharmaceuticals and materials for use in consumer products and ballistic protection. This project will help move metathesis into the realms of natures aqueous environment, a key advance if metathesis is to reveal its full potential in biological, polymeric, and pharmaceutical applications. We specifically aim to target treatments for cataract (and other conditions associated with an aging population) and also important new biopolymers for use in health technologies of the future.Read moreRead less
Material structure and properties of mineralised tissue: An integrated micro and nano level investigation. Bone material properties have a direct influence on disorders of the skeleton, such as osteoporotic bone fragility fractures and osteoarthritis. It has been estimated that the direct and indirect cost of all fragility fractures and arthritis is over $20 billion per annum. The impact of this will be far-reaching with the social benefits ranging from earlier and more accurate diagnoses, to t ....Material structure and properties of mineralised tissue: An integrated micro and nano level investigation. Bone material properties have a direct influence on disorders of the skeleton, such as osteoporotic bone fragility fractures and osteoarthritis. It has been estimated that the direct and indirect cost of all fragility fractures and arthritis is over $20 billion per annum. The impact of this will be far-reaching with the social benefits ranging from earlier and more accurate diagnoses, to the development of preventative strategies to delay the onset of musculoskeletal disorders. These developments will translate into exciting commercial opportunities and overall economic growth and sustainability.Read moreRead less
Investigation of Strategies to Improve the Efficiency of Industrial Radiators and Cooling Coils. Innovative strategies for improving in-service effectiveness of tube & plate-fin heat exchange 'coils' will be explored. Such coils are used throughout chemical process industries, diesel powered plant, vehicles and air-conditioning systems. Coil manufacture is a 'mature' industry, but design concepts have changed little since 1950. Fouling of diesel engine 'radiators' in dusty conditions and in mari ....Investigation of Strategies to Improve the Efficiency of Industrial Radiators and Cooling Coils. Innovative strategies for improving in-service effectiveness of tube & plate-fin heat exchange 'coils' will be explored. Such coils are used throughout chemical process industries, diesel powered plant, vehicles and air-conditioning systems. Coil manufacture is a 'mature' industry, but design concepts have changed little since 1950. Fouling of diesel engine 'radiators' in dusty conditions and in marine environments is endemic. New design concepts evolved via Computational Fluid Dynamic analysis will be manufactured and tested in the unique heat and mass transfer wind tunnel on the University's Industry Liaison Campus. The major outcome will be a rugged design methodology with broad applicability.Read moreRead less
Study of hydrocarbon flames under heat and gas recirculation conditions. This project aims to study gaseous flames under heat and gas recirculation conditions. This technology has been proven to reduce fuel consumption, improve thermal efficiency and substantially reduce nitric oxides emission. The effect of mixing, turbulence and temperature on the structure and stability of these flames will be investigated. The project combines experimental and computational research applied to a laboratory s ....Study of hydrocarbon flames under heat and gas recirculation conditions. This project aims to study gaseous flames under heat and gas recirculation conditions. This technology has been proven to reduce fuel consumption, improve thermal efficiency and substantially reduce nitric oxides emission. The effect of mixing, turbulence and temperature on the structure and stability of these flames will be investigated. The project combines experimental and computational research applied to a laboratory scale burner and a small scale furnace. The main objectives are to better understand the chemical pathways in low temperature hydrocarbon flames under heat and gas recirculation conditions and to understand the effect of mixing and turbulence on the flame structure and pollutants emission.Read moreRead less
Response of Proteins to External Non-Ionising Radiation: an Experimental and Computer Modelling Investigation. The expanding use of digital technologies such as mobile phones has led to major health concerns about the effects of non-ionising pulsed radiation exposure which has been shown to produce instantaneous temperature rises undetectable by normal thermometry. The health implications of exposure are not understandable without establishing molecular mechanisms by which pulsed microwaves can ....Response of Proteins to External Non-Ionising Radiation: an Experimental and Computer Modelling Investigation. The expanding use of digital technologies such as mobile phones has led to major health concerns about the effects of non-ionising pulsed radiation exposure which has been shown to produce instantaneous temperature rises undetectable by normal thermometry. The health implications of exposure are not understandable without establishing molecular mechanisms by which pulsed microwaves can cause biological effects. We aim to establish methods for studying the molecular mechanisms of protein structural and energetic changes occurring due to non-ionising radiation. The results will help our industry partner to design specific drugs as well as formulate a scientifically based standard for microwave utilisation.Read moreRead less
The recovery of Cu from chalcopyrite-pyrite containing concentrates, ores and tailings. Chalcopyrite, a major source of Cu, is often associated in ores with the valueless mineral pyrite. The development of more efficient methods for the retrieval of the Cu is of considerable economic importance to Australian minerals processing companies. We aim to develop methodologies allowing the more efficient :
- separation of chalcopyrite and pyrite;
- leaching of Cu from ores and tailing in a heap leach ....The recovery of Cu from chalcopyrite-pyrite containing concentrates, ores and tailings. Chalcopyrite, a major source of Cu, is often associated in ores with the valueless mineral pyrite. The development of more efficient methods for the retrieval of the Cu is of considerable economic importance to Australian minerals processing companies. We aim to develop methodologies allowing the more efficient :
- separation of chalcopyrite and pyrite;
- leaching of Cu from ores and tailing in a heap leach environment and
- leaching of Cu in a concentrated chalcopyrite-pyrite reactor environment.
These aims will be achieved via an integrated surface-solution speciation approach allowing the manipulation of surface properties.
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Preparation and properties of oligo- and polycyclophanes. Materials with advanced optical and electronic properties. This project aims to prepare a novel class of organic and organometallic material that has both theoretical and practical applications. Nanotechnology requires unique arrangements of atoms that can give rise to enhanced macroscopic properties and we have embarked on a project that will provide new oligomers and polymers for the construction of the next generation of optical and el ....Preparation and properties of oligo- and polycyclophanes. Materials with advanced optical and electronic properties. This project aims to prepare a novel class of organic and organometallic material that has both theoretical and practical applications. Nanotechnology requires unique arrangements of atoms that can give rise to enhanced macroscopic properties and we have embarked on a project that will provide new oligomers and polymers for the construction of the next generation of optical and electronic devices.Read moreRead less
Electron transfer in proteins, a study of mechanism and function. Our research will probe the mechanisms by which nature's living systems build, maintain, and reproduce. We present an ability to understand these processes at a detailed molecular level using science and technology at the forefront of multidisciplinary research. The research will provide a foundation for new smart materials, technologies and future industries, and also ways forward for future basic scientific research and endeavo ....Electron transfer in proteins, a study of mechanism and function. Our research will probe the mechanisms by which nature's living systems build, maintain, and reproduce. We present an ability to understand these processes at a detailed molecular level using science and technology at the forefront of multidisciplinary research. The research will provide a foundation for new smart materials, technologies and future industries, and also ways forward for future basic scientific research and endeavor. All this is done with the best international researchers and capabilities within a local environment that will help to train the next generation of Australian scientists.Read moreRead less
Mimicking peptide structure - towards an aqueous environment. In this proposal we develop a fundamental understanding of the balance between 'weak' and 'strong' forces to define the properties of peptides and proteins. This will allow the design of new biological probes and materials with tailor-made chemical and physical properties for use in bioengineering, biotechnology, proteomics, and drug design. One such example is the design and preparation of a new chemical agent for the non-surgical tr ....Mimicking peptide structure - towards an aqueous environment. In this proposal we develop a fundamental understanding of the balance between 'weak' and 'strong' forces to define the properties of peptides and proteins. This will allow the design of new biological probes and materials with tailor-made chemical and physical properties for use in bioengineering, biotechnology, proteomics, and drug design. One such example is the design and preparation of a new chemical agent for the non-surgical treatment for cataract, the major cause of blindness world-wide.Read moreRead less