The genetics of ageing in human populations. This project aims to test whether genetic differences among individuals influence changes in cognition and physiological function in later life. Differences among individuals, in terms of distinct changes in their physiology as they age, lead to differences in their susceptibility to negative later-life outcomes and ultimately to differences in lifespan. Using a combination of genomic techniques, novel data analysis methods, and the largest dataset of ....The genetics of ageing in human populations. This project aims to test whether genetic differences among individuals influence changes in cognition and physiological function in later life. Differences among individuals, in terms of distinct changes in their physiology as they age, lead to differences in their susceptibility to negative later-life outcomes and ultimately to differences in lifespan. Using a combination of genomic techniques, novel data analysis methods, and the largest dataset of its kind, the project intends to identify the genomic regions and biochemical pathways associated with these changes, and to test for genetic associations between early-life reproduction and later-life outcomes. This is crucial to understanding, predicting and managing transitions across different human life stages.Read moreRead less
Work life after a diagnosis of breast, prostate and colorectal cancer: Major disruption or work as usual. Each year, over 40,000 working-age individuals (as well as their families and workplaces) are affected by a diagnosis of cancer. This novel and important study will, for the first time in Australia, identify the extent and effects of loss of skilled workers from the workforce because of a diagnosis of breast, prostate or colorectal cancer and will lead to the development of new interventions ....Work life after a diagnosis of breast, prostate and colorectal cancer: Major disruption or work as usual. Each year, over 40,000 working-age individuals (as well as their families and workplaces) are affected by a diagnosis of cancer. This novel and important study will, for the first time in Australia, identify the extent and effects of loss of skilled workers from the workforce because of a diagnosis of breast, prostate or colorectal cancer and will lead to the development of new interventions that help people to recover from cancer. This project is critical to help advance health and labour policies in Australia which currently faces an ageing population, global economic unrest and rising unemployment.Read moreRead less
The role of short tandem repeat DNA variation in the evolution of human psychological diversity. The proposed work addresses fundamental questions about human nature. It ties together the evolutionary processes that have shaped us as a species with the way our genes influence: our personalities, the way we think and how we behave. It introduces a novel approach to addressing questions about the role of genetics in human variation that will contribute substantially to the way we understand, perce ....The role of short tandem repeat DNA variation in the evolution of human psychological diversity. The proposed work addresses fundamental questions about human nature. It ties together the evolutionary processes that have shaped us as a species with the way our genes influence: our personalities, the way we think and how we behave. It introduces a novel approach to addressing questions about the role of genetics in human variation that will contribute substantially to the way we understand, perceive and manage important aspects of human diversity.Read moreRead less
Dementia, moral agency and identity. The project aims to examine the ethical issues raised by dementia and the care of those with the condition. The project will examine and evaluate the capacities those with dementia retain for social agency, valuing and relationships. The project will test and refine theories of agency, identity and vulnerability in the light of the cognitive deficits accompanying dementia. The project will lead to the delivery of more efficient healthcare through the developm ....Dementia, moral agency and identity. The project aims to examine the ethical issues raised by dementia and the care of those with the condition. The project will examine and evaluate the capacities those with dementia retain for social agency, valuing and relationships. The project will test and refine theories of agency, identity and vulnerability in the light of the cognitive deficits accompanying dementia. The project will lead to the delivery of more efficient healthcare through the development of increased understandings of the relevant ethical considerations for treatment, and recommendations for new and ethical approaches to policy on dementia. It brings benefits to the well-being and relationships of those with this condition, their families and friends, and the professionals who care for them.Read moreRead less
Social perception in late adulthood. Social perception refers broadly to the ability to decode and react appropriately to the social signals sent out by other people, and is a critical predictor of social competency and wellbeing. The aim of this project is to gain a clearer picture of when and why older adults experience social perceptual difficulties, as well as any consequences of these difficulties. A key prediction is that those older adults who have most difficulty with social perception w ....Social perception in late adulthood. Social perception refers broadly to the ability to decode and react appropriately to the social signals sent out by other people, and is a critical predictor of social competency and wellbeing. The aim of this project is to gain a clearer picture of when and why older adults experience social perceptual difficulties, as well as any consequences of these difficulties. A key prediction is that those older adults who have most difficulty with social perception will also have lowest wellbeing. Identifying which older adults are most likely to experience social perceptual difficulties, as well as which aspects of social perception are relatively intact, are expected to help to guide interventions on how to maintain wellbeing in old age.Read moreRead less
Assessing gene function in the developing brain using zebrafish as a model system. As the average life expectancy in western countries increases there is an increasing incidence of mental health problems in the general population. Therapeutic approaches to Alzhemier's and Parkinson's disease as well as to brain injury arising from stroke rely on a thorough understanding of the molecular and physiological mechanisms of normal growth of this tissue. These are the very processes that need to be rea ....Assessing gene function in the developing brain using zebrafish as a model system. As the average life expectancy in western countries increases there is an increasing incidence of mental health problems in the general population. Therapeutic approaches to Alzhemier's and Parkinson's disease as well as to brain injury arising from stroke rely on a thorough understanding of the molecular and physiological mechanisms of normal growth of this tissue. These are the very processes that need to be reactivated in these diseases for recovery of function. This project seeks to understand normal development of the brain and in doing so it will expose novel targets for therapy in the aged. Read moreRead less
Amplifying Voices from the Royal Commission into Aged Care. The Royal Commission into Aged Care Quality and Safety is a singular opportunity to reform Australian aged care and redress the marginalisation of aged care residents—a vulnerable demographic whose voices too often go unheard. Using innovative arts-based forms of storytelling, this project explores how non-traditional approaches can provide older Australians with more visibility in aged care policy debates. Combining media analysis with ....Amplifying Voices from the Royal Commission into Aged Care. The Royal Commission into Aged Care Quality and Safety is a singular opportunity to reform Australian aged care and redress the marginalisation of aged care residents—a vulnerable demographic whose voices too often go unheard. Using innovative arts-based forms of storytelling, this project explores how non-traditional approaches can provide older Australians with more visibility in aged care policy debates. Combining media analysis with poetic inquiry, participatory photography, citizen storytelling, and interactive art, this project amplifies the voices of residents and engages policy makers, providers, and the public in a reflexive, inclusive conversation about the past, present and future of aged care. Read moreRead less
The feasibility, acceptability and cost-effectiveness of nurse-led models of chronic disease management in general practice. This study directly relates to the National Research Priority of 'promoting and maintaining good health' through our approach to trial a new and innovative model of chronic disease management specifically for CVD and Type II diabetes in general practice. This project aims to test a new model of health service delivery - that is, the use of a practice nurse to provide chro ....The feasibility, acceptability and cost-effectiveness of nurse-led models of chronic disease management in general practice. This study directly relates to the National Research Priority of 'promoting and maintaining good health' through our approach to trial a new and innovative model of chronic disease management specifically for CVD and Type II diabetes in general practice. This project aims to test a new model of health service delivery - that is, the use of a practice nurse to provide chronic disease care rather than a general practitioner. Our strategy involves collaboration with health providers, stakeholders and consumers to help achieve this by providing patient education and disease management through a registered nurse in general practice.Read moreRead less
Addressing significant product safety knowledge gaps for older Australians . This project addresses significant gaps in contemporary knowledge of consumer product safety risks for older persons, with 25 years since the last Australian product safety research found older persons are at high risk of product-related injury/death. Products have evolved substantially and aged care models have changed in that time. This project generates contemporary knowledge of unsafe products causing injuries/death ....Addressing significant product safety knowledge gaps for older Australians . This project addresses significant gaps in contemporary knowledge of consumer product safety risks for older persons, with 25 years since the last Australian product safety research found older persons are at high risk of product-related injury/death. Products have evolved substantially and aged care models have changed in that time. This project generates contemporary knowledge of unsafe products causing injuries/deaths, risk factors/behaviours, and human rights issues. Outcomes benefiting the Australian community are improved prediction/characterisation of product safety issues for older Australians informing safer product design and use, targetted regulatory responses, ageing-in-place strategies, and creating safer home environments.Read moreRead less
Retirement activity planning: a randomised controlled trial. Retirement is a life transition where people must rethink the way they use their time, but little thought is given to planning for this. This project will assess the effect of systematic pre-retirement activity planning on use of time after retirement, with an emphasis on physical activity and sedentary behaviours.