Translating Risk Models To Improve Prevention And Early Diagnosis Of Cancer In Primary Care
Funder
National Health and Medical Research Council
Funding Amount
$479,882.00
Summary
Primary care plays a key role in prevention and early diagnosis of cancer. This fellowship will apply evidence about cancer risk to help GPs provide tailored advice to patients about preventing common cancers. It will also use new risk tools to assess people with symptoms suggestive of cancer to support earlier diagnosis. The research extends to studies relating to how people interpret symptoms and ways of promoting earlier presentation to the GP in patients who are at higher risk of cancer.
Generating And Translating Evidence Into Practice In Womens Health And Beyond
Funder
National Health and Medical Research Council
Funding Amount
$501,659.00
Summary
Obesity is increasing with major reproductive and metabolic health impacts for women and the next generation. This fellowships focuses on prevention of obesity and optimal diagnosis and management of obesity related reproductive and metabolic conditions in women including before and during pregnancy. Translation is vital to deliver health benefits from research. Here Prof Teede will generate new evidence and translate this into practice in women’s health and beyond to deliver tangible impact.
Modernizing The Knowledge Base For Reproductive Health Care: Individual Patient Data Meta-analysis As The New Standard For Evidence Synthesis In Reproductive Health.
Funder
National Health and Medical Research Council
Funding Amount
$575,662.00
Summary
Characteristics of sick persons differ, and criteria that have been used to include them in studies may not match the individual profile of individuals who typically present to the health system. I propose a step towards more personalised medicine, which is new in the field of reproductive health. In a global collaboration, we plan to collect individual participant data of studies, and develop clinical rules and guidelines that tailor the individual profile of the sick individual.
Australia has an ageing population and women spend around one third of their lives after menopause. Optimising physical and emotional health at menopause is a national health priority, and improving the health of women will improve health for the community. This research program is targeted at improving physical and mental health for midlife and older women. Findings will be translated into changes in policy and practice which improve the lives of women in Australia and worldwide
Optimising Evidence-based, Equitable And Efficient Care For Common Child Health Conditions.
Funder
National Health and Medical Research Council
Funding Amount
$481,156.00
Summary
Care for common conditions such as sleep problems, mental health disorders, and food allergy is often plagued by mismanagement, long wait times, inequitable access, and waste. These factors can worsen child health and quality of life, increase financial and social pressures on families, and deplete the limited health budget. I will develop, implement and evaluate innovative and sustainable solutions to improve care, access to care, and reduce waste in these conditions.
Early Life Approaches To Obesity Prevention – The Role Of The In-utero Environment
Funder
National Health and Medical Research Council
Funding Amount
$575,662.00
Summary
This proposal will comprehensively evaluate the role of maternal overweight and obesity, gestational weight gain, and the effects of antenatal dietary and lifestyle interventions on maternal, infant and childhood health outcomes. Over 50% of pregnant women are overweight or obese, with adverse outcomes for maternal and infant health, both immediately related to pregnancy, and in the longer term. Outcomes from this proposal will inform clinical guidelines and improve practice.
Working With Indigenous Services And Communities To Reduce The Harms From Alcohol
Funder
National Health and Medical Research Council
Funding Amount
$474,513.00
Summary
Indigenous Australians face up to eight times the rate of hospitalisation for alcohol-related conditions. Reducing this burden will be key to closing the health gap. Professor Kate Conigrave will build on longstanding partnerships with Indigenous communities, services and health professionals to conduct a 5-year program of work aimed at improving treatment and prevention of alcohol problems. This will span settings including Indigenous primary health services, prisons and whole communities.
I will determine the efficacy and safety of crystalloid resuscitation fluids in conventional models of care. This is a fundamental and unresolved question in Intensive Care Medicine and will have an impact on clinical practice worldwide. I will also consolidate and enhance a series of projects to provide the next generation of clinician-researchers with high-quality research opportunities. These include projects in sepsis, traumatic brain injury, and endocrine function in critical illness.
Precision Medicine For Epilepsy And Beyond: From Discovery To Implementation And Evaluation
Funder
National Health and Medical Research Council
Funding Amount
$487,891.00
Summary
The theme of this Fellowship is to improve treatment outcomes using a genomic-based Precision Medicine approach. This goal will be achieved by 3 closely linked projects that harness the power of gene sequencing and advances in biosensor technology, coupled with careful clinical and health economic evaluation. While the emphasis is on epilepsy, the research will extend to other major disease areas of global health significance. The potential socioeconomic impact of these innovations is enormous.
Immunisation is second only to clean water and sanitation as a life-saving activity. Vaccine safety is considered to be very important by the general public, the media and the health professions. With so many diseases controlled and now rare, the safety of vaccines assumes greater importance. Research is needed on new and safer vaccines, using e.g. a needle-free approach, against old foes, like influenza, and new enemies (like MERS) with vaccine safety more important than ever.