Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100137
Funder
Australian Research Council
Funding Amount
$881,758.00
Summary
Australian Environmental Specimen Bank: advancing specimen bank capability. The aim of this LIEF is to advance Australia’s specimen banking capabilities through a new, enhanced national facility, the Australian Environmental Specimen Bank (AESB). The AESB would be founded on a unique current archive of human and environmental samples established by the partners to the LIEF. Importantly, the AESB would be managed as a nationally available (to all public sector researchers), operationally self-fun ....Australian Environmental Specimen Bank: advancing specimen bank capability. The aim of this LIEF is to advance Australia’s specimen banking capabilities through a new, enhanced national facility, the Australian Environmental Specimen Bank (AESB). The AESB would be founded on a unique current archive of human and environmental samples established by the partners to the LIEF. Importantly, the AESB would be managed as a nationally available (to all public sector researchers), operationally self-funded resource for integrated exposure research into the future. The archive is expected to support longitudinal and cross-sectional studies to assess trends in exposure to chemical and biological hazards in the Australian population, identify emerging hazards, and provide a scientific basis for policy and regulatory actions.Read moreRead less
Understanding third hand exposure of Australian people to methamphetamine. In Australia, there is high community concern around inadvertent exposure to methamphetamine residues in contaminated houses. In this proposal, an interdisciplinary research team aim to engage with public health authorities and public housing industry to conduct collaborative research on total exposure to methamphetamine in contaminated indoor environments. The project will assess exposure pathways (via air, dust, surface ....Understanding third hand exposure of Australian people to methamphetamine. In Australia, there is high community concern around inadvertent exposure to methamphetamine residues in contaminated houses. In this proposal, an interdisciplinary research team aim to engage with public health authorities and public housing industry to conduct collaborative research on total exposure to methamphetamine in contaminated indoor environments. The project will assess exposure pathways (via air, dust, surfaces) and link them with methamphetamine levels in samples from occupants (urine, hair). The project is expected to significantly enhance our understanding of how third hand exposure leads to internal exposure in humans. This knowledge provides evidence for policies on residential indoor exposures and remediation strategies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120100161
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Accumulation and half-lives of brominated flame retardants. This project seeks to determine, in vivo, previously unknown half-lives for brominated flame retardants, chemicals used in numerous, everyday products. This is vital for predicting the duration of human contamination with these persistent, toxic, bioaccumulative chemicals and assessing effectiveness of legislation to reduce human exposure.
Reducing glyphosate exposure from high use practices. This project aims to investigate methods of reducing occupational exposure to glyphosate, a ubiquitous pollutant of emerging concern. This will be achieved through developing new cost-effective analytical and sampling tools and refining methods for integrating human exposure (biomonitoring) data with surveillance data on the pathways of glyphosate exposure from high use. The project will generate new targeted knowledge on (sub) population-spe ....Reducing glyphosate exposure from high use practices. This project aims to investigate methods of reducing occupational exposure to glyphosate, a ubiquitous pollutant of emerging concern. This will be achieved through developing new cost-effective analytical and sampling tools and refining methods for integrating human exposure (biomonitoring) data with surveillance data on the pathways of glyphosate exposure from high use. The project will generate new targeted knowledge on (sub) population-specific chemical exposures in Australia, and globally. Such data are critical to inform public health and chemical regulation policy, and provide clear guidance aimed at reducing exposures, to assess the effectiveness of existing regulations, and provide a framework for implementing surveys in the future.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL200100028
Funder
Australian Research Council
Funding Amount
$2,854,682.00
Summary
Transforming our understanding of the chemical exposome. Despite many benefits associated with the use of chemicals, there is consensus that their accelerated production and use is increasingly affecting environmental health. Effective tools to understand spatiotemporal trends and factors that drive chemical exposure are urgently needed. This project aims to develop these tools by combining established programs in systematic sampling and archiving with advanced informatics and analytical techniq ....Transforming our understanding of the chemical exposome. Despite many benefits associated with the use of chemicals, there is consensus that their accelerated production and use is increasingly affecting environmental health. Effective tools to understand spatiotemporal trends and factors that drive chemical exposure are urgently needed. This project aims to develop these tools by combining established programs in systematic sampling and archiving with advanced informatics and analytical techniques. The project expects to identify emerging chemicals of concern, assess factors that affect exposure and model exposure based on chemical production, use and fate. Outcomes will support evidence-based regulation and management of chemicals to minimise adverse impacts of chemical exposure in Australia.Read moreRead less
Understanding changes in chemical exposure through integrative sampling and systematic archiving. Poor data on exposure limits our understanding of the effects of chemical exposure on health. This project will aim to develop population-based exposure monitoring strategies to measure exposure, exposure trends, the success of intervention strategies and associations between exposure and health outcomes.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100129
Funder
Australian Research Council
Funding Amount
$249,000.00
Summary
Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring. Microflow ultra high pressure liquid chromatography – high resolution mass spectrometry for chemical exposure monitoring: Identifying new chemicals of interest in environmental or biological samples is the first critical step toward understanding their impact to human and environment. A state-of-the-art microflow ultra high performance liquid chromatography high resolution ma ....Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring. Microflow ultra high pressure liquid chromatography – high resolution mass spectrometry for chemical exposure monitoring: Identifying new chemicals of interest in environmental or biological samples is the first critical step toward understanding their impact to human and environment. A state-of-the-art microflow ultra high performance liquid chromatography high resolution mass spectrometer is fundamental to extend our research capabilities to new environmental contaminants and environmental exposure biomarkers, as well as consumption biomarkers of new illicit drugs and their metabolites. This instrument will fill an important gap in our capacity to link health/ecological risk to unknown chemicals and will allow interdisciplinary researchers to advance work in environmental toxicology, chemistry and forensics.Read moreRead less
Estimating per capita use and release of chemicals by wastewater analysis. This project aims to systematically collect and analyse wastewater to assess human exposure to chemicals including drugs, pharmaceuticals, lifestyle chemicals and environmental pollutants. By combining temporal sampling from key sewage treatment plants with comprehensive nationwide sampling over the week of the 2016 census day, the project expects to estimate the per-capita human exposure to chemicals in the Australian po ....Estimating per capita use and release of chemicals by wastewater analysis. This project aims to systematically collect and analyse wastewater to assess human exposure to chemicals including drugs, pharmaceuticals, lifestyle chemicals and environmental pollutants. By combining temporal sampling from key sewage treatment plants with comprehensive nationwide sampling over the week of the 2016 census day, the project expects to estimate the per-capita human exposure to chemicals in the Australian population. Accurate and objective per-capita based consumption and release estimates for a wide range of chemicals is intended to provide a baseline against which to measure changes in our chemosphere.Read moreRead less
Realistic assessment of biomarker transformation in the wastewater system. Wastewater-based epidemiology is an internationally recognised cost-effective tool to monitor population exposure to chemicals and infectious diseases including Covid-19. However, in-sewer degradation of critical biomarkers can limit their wastewater-based epidemiology suitability. This project aims to systematically evaluate the stability of a new suite of potential biomarkers and conduct the first Australia-wide assessm ....Realistic assessment of biomarker transformation in the wastewater system. Wastewater-based epidemiology is an internationally recognised cost-effective tool to monitor population exposure to chemicals and infectious diseases including Covid-19. However, in-sewer degradation of critical biomarkers can limit their wastewater-based epidemiology suitability. This project aims to systematically evaluate the stability of a new suite of potential biomarkers and conduct the first Australia-wide assessment on the impact of biomarker stability on wastewater-based epidemiology estimates using wastewater samples from ~65% of the Australian population. The project expects to generate knowledge to expand the application of wastewater-based epidemiology to reliably quantify exposure and status of well-being even in remote areasRead moreRead less
Exposure mapping - combining wastewater analysis with human biomonitoring. This project aims to develop a spatial and temporal understanding of chemical exposure in the Australian population. The project will use wastewater samples collected from over 100 catchments (65% of Australian population) during the 2016 Census to spatially resolve human exposure to chemicals. These data will then form the basis for focused human biomonitoring using pooled surplus pathology samples. The integration of ....Exposure mapping - combining wastewater analysis with human biomonitoring. This project aims to develop a spatial and temporal understanding of chemical exposure in the Australian population. The project will use wastewater samples collected from over 100 catchments (65% of Australian population) during the 2016 Census to spatially resolve human exposure to chemicals. These data will then form the basis for focused human biomonitoring using pooled surplus pathology samples. The integration of wastewater and biomonitoring data will allow the creation of a national hazard specific exposure map that can be compared with geospatial data on disease risk and socioeconomic indicators (via ABS information). The benefits include the capability to identify and manage exposure risks to public health.Read moreRead less