A Population-based Record Linkage Study Of The Impact Of Chlamydia Infection On Reproductive Health In Women
Funder
National Health and Medical Research Council
Funding Amount
$405,114.00
Summary
Chlamydia is the most commonly notified infection in young Australian women and reports of cases are increasing. While chlamydia is thought to result in infertility and ectopic pregnancy in later life, the evidence for this is limited. This will be the largest, most comprehensive study in the world to determine the risk of infertility and ectopic pregnancy following chlamydia infection. The results will provide vital information to more cost-effectively plan strategies to control chlamydia in Au ....Chlamydia is the most commonly notified infection in young Australian women and reports of cases are increasing. While chlamydia is thought to result in infertility and ectopic pregnancy in later life, the evidence for this is limited. This will be the largest, most comprehensive study in the world to determine the risk of infertility and ectopic pregnancy following chlamydia infection. The results will provide vital information to more cost-effectively plan strategies to control chlamydia in Australia.Read moreRead less
SCALE-C: Strategies For Hepatitis C Testing And Treatment In Aboriginal Communities That Lead To Elimination
Funder
National Health and Medical Research Council
Funding Amount
$2,175,170.00
Summary
Prevalence of hepatitis C infection within the Aboriginal population is among the highest of any identifiable population in Australia. Highly effective, direct-acting antiviral (DAA) therapy, and their listing on the PBS in 2016 has revolutionised HCV clinical management in Australia. The SCALE-C study will evaluate an established test and treat model to rapidly scale-up DAA within four Aboriginal communities to determine both impact on community prevalence and ongoing transmission.
New Strategies To Increase Testing And Treatment For Endemic Sexually Transmitted Infections In Remote Aboriginal Communities
Funder
National Health and Medical Research Council
Funding Amount
$982,228.00
Summary
We will undertake a trial of two new approaches to increase the number of people being tested for curable sexually transmitted infection in remote Aboriginal communities. One strategy will involve offering community members a means of being tested without having to see a clinician unless the result is positive, and the other will involve a financial incentive. The study will provide new ways forward in the long and challenging campaign to rid remote communities of the burden of curable STIs.
Improving Delivery Of Secondary Prophylaxis For Rheumatic Heart Disease: A Stepped-wedge, Community-randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,913,074.00
Summary
Rheumatic heart disease (RHD) is a major health problem in Indigenous communities. Continued progress in controlling RHD requires an understanding of how to improve delivery of regular injections of penicillin - secondary prophylaxis (SP). We will evaluate a systems-based approach to improving delivery of SP, using a stepped-wedge trial in 12 communities in NT and Qld. If successful, this model will provide a practical and transferable model.
The Central Australian Heart Protection Study: A Randomised Trial Of Nurse-Led, Family Based Secondary Prevention Of Acute Coronary Syndromes
Funder
National Health and Medical Research Council
Funding Amount
$1,923,630.00
Summary
Despite the high burden of cardiovascular diseases among Indigenous Australians, few intervention trials have sought to evaluate novel approaches to reducing differential outcomes in this vulnerable group. The Central Australian Heart Protection Study seeks to test the effectiveness of a nurse-led, family based education and assessment program in reducing the incidence of poor outcomes in indigenous and non-indigenous patient’s following an Acute Coronary Syndrome (ACS).
Personalised Medicine Markers Of Anti-EGFR Antibody Therapy In Metastatic Colorectal Cancer: Accelerating Clinical Translation With Collaborative Meta-analyses Based On Individual-participant Data
Funder
National Health and Medical Research Council
Funding Amount
$300,953.00
Summary
When selecting cancer therapy we take into account ‘biomarkers’, biological cancer characteristics that predict treatment success. We will work with an international group, the Advanced Colorectal Cancer Database, to analyse individual patient clinical trial data. We intend to validate biomarkers used to select treatment with cetuximab or panitumumab. Cancer genes called KRAS, NRAS, PTEN, PIK3CA, EREG and BRAF will be examined. Our study will provide best evidence for personalised treatment.
The Forgotten Generation: Understanding Health Trajectories In Aboriginal Adolescents And Youth
Funder
National Health and Medical Research Council
Funding Amount
$2,095,283.00
Summary
This study will establish a cohort of 2250 young Aboriginal and Torres Strait Islander people from urban, rural and remote communities aged 10 to 24 years. The study will provide longitudinal data on the health status and health trajectories of this group of young Australians who experience poorer health outcomes compared with other young Australians. The proposed study will explored the determinants of health status, how these factors change over time and opportunities for prevention.
Does A Health In All Policies Approach Improve Health, Well-being And Equity?
Funder
National Health and Medical Research Council
Funding Amount
$968,325.00
Summary
This project will develop understanding of complex policy initiatives for health & well being which operate across government departments. It will do this through a case study of the SA Government’s Health in All Policies approach which aims to get government departments to develop policies which build a healthier population and reduce health inequities. This research will assess that process, report on what helps and hinders and develop research methods suitable for complex policy evaluation.
The Childhood Resilience Study: Building The Evidence To Reduce Health Inequalities Across The Lifecourse
Funder
National Health and Medical Research Council
Funding Amount
$1,075,842.00
Summary
Children exposed to social adversity, family violence and trauma have higher risks of emotional, developmental and physical health problems. Despite this, many children experiencing social adversity and trauma grow up with positive outcomes. This will be the first international study of resilience in middle childhood. The study will examine factors promoting resilience in Aboriginal children, children exposed to family violence and children in families of refugee background.
Preventing Hospital Readmission In A Regional Australian Hospital Setting
Funder
National Health and Medical Research Council
Funding Amount
$565,695.00
Summary
Hospitals face high levels of emergency presentations and demand for inpatient care particularly for Aboriginal Australian people from remote communities. Readmissions lead to overcrowded emergency departments and poorer patient outcomes. We will evaluate the efficacy of a multidimensional case-based management intervention linking hospital and primary health in a regional Australian hospital with the aim of reducing hospital readmission and improving patient outcomes.