Improving productivity: theory and application to Australian hospitals. This project aims to improve existing methods for analysing productivity and efficiency of organisations. The new methods will be applied to Australian hospitals, to analyse their productivity and efficiency, identify the best-practices and their determinants and recommend improvements and necessary reforms. The high level of healthcare costs in Australia, about 5 percent of gross domestic product, as well as their rapid and ....Improving productivity: theory and application to Australian hospitals. This project aims to improve existing methods for analysing productivity and efficiency of organisations. The new methods will be applied to Australian hospitals, to analyse their productivity and efficiency, identify the best-practices and their determinants and recommend improvements and necessary reforms. The high level of healthcare costs in Australia, about 5 percent of gross domestic product, as well as their rapid and accelerating growth, imply that application of methods developed through this project may save billions of dollars and, more importantly, thousands of lives. An expected outcome of this project will be superior theoretical and practical methods for analysing productivity and efficiency of economic systems, to enhance understanding of the potential for improvements and of the necessary reforms.Read moreRead less
A New Paradigm for Understanding and Improving the Effective Use of Information Systems in Organisations. In an information-based economy, the critical issue for many organisations is how to leverage their information systems effectively. Remarkably, there is almost no detailed research on this topic. This project will address this problem by building a new paradigm for research on the effective use of information systems in organisations. It will involve developing and testing two complementa ....A New Paradigm for Understanding and Improving the Effective Use of Information Systems in Organisations. In an information-based economy, the critical issue for many organisations is how to leverage their information systems effectively. Remarkably, there is almost no detailed research on this topic. This project will address this problem by building a new paradigm for research on the effective use of information systems in organisations. It will involve developing and testing two complementary theories of effective use and designing and testing a novel intervention to facilitate more effective use in an organisation. To maximise academic and practical value, it involves a rigorous program of empirical work in the information-intensive industries of Healthcare and Information Systems Auditing in Australia and Canada. Read moreRead less
Evaluating and developing the evidence-base and data mining approaches to strengthen the consumer product safety system in Australia. Consumer product-related injuries cause over 173,000 injuries per year though there is limited evidence about the causes and risks to enable early identification and warnings for consumers. This project will evaluate the evidence-base and develop new methods to support an early identification and surveillance system for product-related injuries.
Pathways to agri-food supply chains that co-benefit people and nature. This project aims to improve biodiversity outcomes of agricultural food production and consumption, and expects to generate new knowledge about impacts of interventions and shocks on the environment, human health and livelihoods in agri-food systems. This will be achieved using an interdisciplinary approach that accounts for uncertainties in links between farmers, suppliers, consumers and supply-chain outcomes. The expected o ....Pathways to agri-food supply chains that co-benefit people and nature. This project aims to improve biodiversity outcomes of agricultural food production and consumption, and expects to generate new knowledge about impacts of interventions and shocks on the environment, human health and livelihoods in agri-food systems. This will be achieved using an interdisciplinary approach that accounts for uncertainties in links between farmers, suppliers, consumers and supply-chain outcomes. The expected outcome is a value of information framework for identifying nature-friendly policies and actions with co-benefits for human well-being. Benefits include sustainability pathways with win-win outcomes for people and nature, and improved ways of meeting international commitments such as Sustainable Development Goals.Read moreRead less
Uncovering a novel energy-sensing mechanism in the brain. This project aims to investigate a novel regulator of energy homeostasis in the brain, a protein kinase called SIK3. Energy homeostasis is essential for life as it ensures an adequate supply of fuel to cells of the body. This project intends to generate new knowledge about molecular switches to regulate energy homeostasis by using innovative gene technologies and transgenic animal models. The expected outcomes include generating fundament ....Uncovering a novel energy-sensing mechanism in the brain. This project aims to investigate a novel regulator of energy homeostasis in the brain, a protein kinase called SIK3. Energy homeostasis is essential for life as it ensures an adequate supply of fuel to cells of the body. This project intends to generate new knowledge about molecular switches to regulate energy homeostasis by using innovative gene technologies and transgenic animal models. The expected outcomes include generating fundamental insights into how SIK3 in the hypothalamic neurons regulates energy homeostasis. Benefits include improving population health and wellbeing, informing the development of new bio-medical technologies, and expanding the capabilities of Australia’s next generation of researchers.
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Impaired innate antiviral immunity predisposes toward virus-associated airway remodelling in childhood asthma. Increased airway smooth muscle (ASM) mass is the major pathological feature of asthma that causes poor lung function. ASM remodelling occurs in early life, is refractory to current treatments and persists into later life. Severe respiratory virus infections in early life are a major risk factor for the development of asthma, yet it remains to be determined whether viruses promote ASM re ....Impaired innate antiviral immunity predisposes toward virus-associated airway remodelling in childhood asthma. Increased airway smooth muscle (ASM) mass is the major pathological feature of asthma that causes poor lung function. ASM remodelling occurs in early life, is refractory to current treatments and persists into later life. Severe respiratory virus infections in early life are a major risk factor for the development of asthma, yet it remains to be determined whether viruses promote ASM remodelling. Previous studies have developed a unique mouse model of childhood asthma and discovered the molecular mechanism by which this tissue tropism develops in response to virus infection. This project will identify new targets for immunomodulation and design new biologics to block ASM remodelling and the deleterious effects of respiratory virus infection in asthmatic subjects. Read moreRead less
Using toxins to understand the mechanisms of pain. Toxins have evolved in plants, animals and microbes as part of defensive and/or prey capture strategies, and have proven to be invaluable research tools as well as providing leads for potential new therapies. This project will use subtype-selective toxins to define the role of ion channels in pain, using novel pathway-specific and disease-specific animal models of pain. The findings from this project will provide significant insight into the ne ....Using toxins to understand the mechanisms of pain. Toxins have evolved in plants, animals and microbes as part of defensive and/or prey capture strategies, and have proven to be invaluable research tools as well as providing leads for potential new therapies. This project will use subtype-selective toxins to define the role of ion channels in pain, using novel pathway-specific and disease-specific animal models of pain. The findings from this project will provide significant insight into the neuropharmacology of pain, will lead to the identification of novel molecular targets with analgesic potential and is expected to provide novel treatment approaches for pain.Read moreRead less
A community-based approach to the problem of underage drinking. This project will aim to reduce the frequency and amount of alcohol consumption, and alcohol-related harms, among young people aged 12-17 years by addressing social norms regarding underage alcohol consumption. Using a multi-component intervention it will engage the Illawarra community in strategies to encourage and empower young people not to drink.
Excessive sitting and population health: strengthening the science and the relevance to policy and practice. The majority of Australian adults spend most of their waking hours sitting; this increases the likelihood of developing diseases of inactivity, including diabetes, heart disease and some cancers. New research will investigate what factors encourage excessive sitting and what the health benefits are for people who deliberately do less sitting.
The grand challenge of predicting human movement energetics. This Project aims to advance our understanding of how the neuromuscular system uses energy during movement by exploring the interplay of different factors that influence movement energetics. The Project will explore different levels of organisation; from how muscle fibres consume energy to how those fibres interact and are subsequently controlled within a complex neuromuscular system. Expected outcomes of this Project will be an improv ....The grand challenge of predicting human movement energetics. This Project aims to advance our understanding of how the neuromuscular system uses energy during movement by exploring the interplay of different factors that influence movement energetics. The Project will explore different levels of organisation; from how muscle fibres consume energy to how those fibres interact and are subsequently controlled within a complex neuromuscular system. Expected outcomes of this Project will be an improved capacity to predict energy expenditure of the vast array of movements that humans perform. This will enable accurate monitoring of human energy expenditure and will provide benefits for individualised exercise prescription, enhancing work productivity or designing devices to augment human performance.Read moreRead less