Using multiple data sources to understand the opioid crisis in Australia . This project aims to improve the quality and integration of population-level data for monitoring the consumption of opioids, licit and illicit, in Queensland communities. The analysis of opioids in wastewater, integrated with opioid use information such as prescription and seizure statistics will vastly increase knowledge of consumption patterns of opioids. By analysing wastewater samples from 2011 and triangulating with ....Using multiple data sources to understand the opioid crisis in Australia . This project aims to improve the quality and integration of population-level data for monitoring the consumption of opioids, licit and illicit, in Queensland communities. The analysis of opioids in wastewater, integrated with opioid use information such as prescription and seizure statistics will vastly increase knowledge of consumption patterns of opioids. By analysing wastewater samples from 2011 and triangulating with other datasets, the expected outcomes include building capacity to estimate consumption of all opioids; detecting the misuse of licit and illicit opioids over time. Anticipated benefit is to provide objective evidence of opioid use patterns for decision makers and a framework for a national opioids monitoring program.Read moreRead less
The impact of light intensity during night shifts on circadian adaptation. Each year, the sleep loss and body clock disruption caused by night work cost the Australian economy $2–3 billion in lost productivity, impaired well-being, and poor health. Current regulations limit sequences of night shifts to a maximum of four in a row. However, recent research suggests that this blanket limit may be a well-intentioned, but ill-informed, policy. As a result, we may be inadvertently increasing, rather t ....The impact of light intensity during night shifts on circadian adaptation. Each year, the sleep loss and body clock disruption caused by night work cost the Australian economy $2–3 billion in lost productivity, impaired well-being, and poor health. Current regulations limit sequences of night shifts to a maximum of four in a row. However, recent research suggests that this blanket limit may be a well-intentioned, but ill-informed, policy. As a result, we may be inadvertently increasing, rather than reducing, work-related fatigue. This project will determine whether longer sequences of night shifts may reduce sleep loss and body clock disruption in some workplaces. The project will provide the evidence base for a more nuanced approach to fatigue regulation and a safer workplace for Australian shiftworkers. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100381
Funder
Australian Research Council
Funding Amount
$444,000.00
Summary
Facilitating detection of new psychoactive substances in wastewater. This project aims to develop and apply novel analytical methods for detecting new psychoactive substances (NPS) in wastewater. NPS are a dynamic, complex addition to the illicit drug market, and a persistent analytical challenge for wastewater analysis. This project expects to fill the current knowledge gap in detection and identification of these substances in wastewater. This will provide substantial benefits both to Australi ....Facilitating detection of new psychoactive substances in wastewater. This project aims to develop and apply novel analytical methods for detecting new psychoactive substances (NPS) in wastewater. NPS are a dynamic, complex addition to the illicit drug market, and a persistent analytical challenge for wastewater analysis. This project expects to fill the current knowledge gap in detection and identification of these substances in wastewater. This will provide substantial benefits both to Australia and internationally by aiding development of early warning drug monitoring systems, providing the rapid deployment of interventions to reduce drug-related harm in the local community, while facilitating law and government agencies to better direct resources.Read moreRead less
A global platform for identifying emerging chemical threats. This project aims to develop an automated early warning social network to systematically detect newly identified emerging chemical threats. Rapid identification of chemical exposures is key to managing chemical threats and associated risks. Global collaboration and sharing of archived, high-resolution mass spectrometry data through open/social platforms will revolutionise data processing and chemical threat identification. This project ....A global platform for identifying emerging chemical threats. This project aims to develop an automated early warning social network to systematically detect newly identified emerging chemical threats. Rapid identification of chemical exposures is key to managing chemical threats and associated risks. Global collaboration and sharing of archived, high-resolution mass spectrometry data through open/social platforms will revolutionise data processing and chemical threat identification. This project will result in a new and cost-effective approach for the identification, tracking and prioritisation of emerging chemical threats and address key national and global health risks. The outcomes include the first spatial and temporal distribution of new emerging chemical threats in Australia.Read moreRead less
Reducing glyphosate exposure from high use practices. This project aims to investigate methods of reducing occupational exposure to glyphosate, a ubiquitous pollutant of emerging concern. This will be achieved through developing new cost-effective analytical and sampling tools and refining methods for integrating human exposure (biomonitoring) data with surveillance data on the pathways of glyphosate exposure from high use. The project will generate new targeted knowledge on (sub) population-spe ....Reducing glyphosate exposure from high use practices. This project aims to investigate methods of reducing occupational exposure to glyphosate, a ubiquitous pollutant of emerging concern. This will be achieved through developing new cost-effective analytical and sampling tools and refining methods for integrating human exposure (biomonitoring) data with surveillance data on the pathways of glyphosate exposure from high use. The project will generate new targeted knowledge on (sub) population-specific chemical exposures in Australia, and globally. Such data are critical to inform public health and chemical regulation policy, and provide clear guidance aimed at reducing exposures, to assess the effectiveness of existing regulations, and provide a framework for implementing surveys in the future.Read moreRead less
Improving workplace productivity via an AI-based physical activity chatbot . This project aims to develop, train and evaluate a physical activity chatbot using artificial intelligence and machine learning to improve workplace productivity in sedentary office workers. Productivity losses, due to high numbers of physically inactive workers, cost the Australian economy $14 billion per year. The cost of effective and scalable workplace physical activity programs acts as a barrier to their implementa ....Improving workplace productivity via an AI-based physical activity chatbot . This project aims to develop, train and evaluate a physical activity chatbot using artificial intelligence and machine learning to improve workplace productivity in sedentary office workers. Productivity losses, due to high numbers of physically inactive workers, cost the Australian economy $14 billion per year. The cost of effective and scalable workplace physical activity programs acts as a barrier to their implementation. As such, innovative programs that can reach large numbers of workers at minimal cost are needed. This project aims to generate new knowledge on the use of artificial intelligence to achieve behavioural improvements and will lead to the development of a new type of behaviour change program with broad applicability.
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Understanding how an old heart gets stiff. Aging is accompanied by a stiffening of the heart and reduced function, which is accelerated by cardiovascular disease and leads to heart failure. How the heart stiffens is poorly understood. A new mechanism is proposed here, involving structural membrane proteins (termed caveolae and cavins) and a signalling molecule (nitric oxide). The current research aims to unravel the interplay between cardiac cells and these proteins/signals to cause stiffness an ....Understanding how an old heart gets stiff. Aging is accompanied by a stiffening of the heart and reduced function, which is accelerated by cardiovascular disease and leads to heart failure. How the heart stiffens is poorly understood. A new mechanism is proposed here, involving structural membrane proteins (termed caveolae and cavins) and a signalling molecule (nitric oxide). The current research aims to unravel the interplay between cardiac cells and these proteins/signals to cause stiffness and to determine whether this process governs normal aging of the heart. This work will advance understanding of how heart function is determined and reveal how the human heart changes with normal aging. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100585
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Does foot shape even matter? Rethinking the function of the human foot. Human feet are unique in shape and structure, having evolved to allow upright locomotion. Despite their importance, we don’t understand how foot shape and structure facilitates upright locomotion.This DECRA aims to explore the relationship between foot morphology and foot function. I will close a large knowledge gap by applying novel experimental and shape modelling approaches to provide unprecedented insights into human foo ....Does foot shape even matter? Rethinking the function of the human foot. Human feet are unique in shape and structure, having evolved to allow upright locomotion. Despite their importance, we don’t understand how foot shape and structure facilitates upright locomotion.This DECRA aims to explore the relationship between foot morphology and foot function. I will close a large knowledge gap by applying novel experimental and shape modelling approaches to provide unprecedented insights into human foot function. The primary expected outcome is a detailed understanding of how foot shape and structure influences our ability to walk and run. This research will create a paradigm shift in how we think about feet in the context of human evolution, human athletic performance and athletic footwear design.Read moreRead less
Generalised Degrees of Freedom and Probabilistic Regularisation. This project intends to develop novel statistical tools for more accurate prediction by taking account of model complexity and uncertainties associated with the fitting procedure. The project also plans to develop a novel shrinkage approach via new penalty functions to avoid over-fitting and asymptotic properties. The key applications may include genetic studies where the number of predictors is large and biological experiments whe ....Generalised Degrees of Freedom and Probabilistic Regularisation. This project intends to develop novel statistical tools for more accurate prediction by taking account of model complexity and uncertainties associated with the fitting procedure. The project also plans to develop a novel shrinkage approach via new penalty functions to avoid over-fitting and asymptotic properties. The key applications may include genetic studies where the number of predictors is large and biological experiments where multivariate and temporal data are often collected – for example economical breeding in animal and fish farming and more effectively detecting the genes of interest in genetic studies on human, animals and plants.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100235
Funder
Australian Research Council
Funding Amount
$422,241.00
Summary
The impact of mass gathering events on emergency healthcare services. Mass gathering events (MGEs) occur frequently across Australia. The preparation of a MGE from an emergency healthcare service perspective is conducted with limited evidence to support decision-making. Using routinely collected data from Tourism and Events Queensland, Queensland Ambulance Service, Queensland Emergency Departments, and the Bureau of Meteorology, this research aims to determine the impact on ambulance and emergen ....The impact of mass gathering events on emergency healthcare services. Mass gathering events (MGEs) occur frequently across Australia. The preparation of a MGE from an emergency healthcare service perspective is conducted with limited evidence to support decision-making. Using routinely collected data from Tourism and Events Queensland, Queensland Ambulance Service, Queensland Emergency Departments, and the Bureau of Meteorology, this research aims to determine the impact on ambulance and emergency department services in the vicinity of 750 planned MGEs over a five year period (2015 - 2019). The expected outcome includes an enhanced ability to predict the required emergency healthcare services for a MGE, therefore enhancing the planning and response, benefiting MGE attendees and the MGE host community.Read moreRead less