The impact of light intensity during night shifts on circadian adaptation. Each year, the sleep loss and body clock disruption caused by night work cost the Australian economy $2–3 billion in lost productivity, impaired well-being, and poor health. Current regulations limit sequences of night shifts to a maximum of four in a row. However, recent research suggests that this blanket limit may be a well-intentioned, but ill-informed, policy. As a result, we may be inadvertently increasing, rather t ....The impact of light intensity during night shifts on circadian adaptation. Each year, the sleep loss and body clock disruption caused by night work cost the Australian economy $2–3 billion in lost productivity, impaired well-being, and poor health. Current regulations limit sequences of night shifts to a maximum of four in a row. However, recent research suggests that this blanket limit may be a well-intentioned, but ill-informed, policy. As a result, we may be inadvertently increasing, rather than reducing, work-related fatigue. This project will determine whether longer sequences of night shifts may reduce sleep loss and body clock disruption in some workplaces. The project will provide the evidence base for a more nuanced approach to fatigue regulation and a safer workplace for Australian shiftworkers. Read moreRead less
A global platform for identifying emerging chemical threats. This project aims to develop an automated early warning social network to systematically detect newly identified emerging chemical threats. Rapid identification of chemical exposures is key to managing chemical threats and associated risks. Global collaboration and sharing of archived, high-resolution mass spectrometry data through open/social platforms will revolutionise data processing and chemical threat identification. This project ....A global platform for identifying emerging chemical threats. This project aims to develop an automated early warning social network to systematically detect newly identified emerging chemical threats. Rapid identification of chemical exposures is key to managing chemical threats and associated risks. Global collaboration and sharing of archived, high-resolution mass spectrometry data through open/social platforms will revolutionise data processing and chemical threat identification. This project will result in a new and cost-effective approach for the identification, tracking and prioritisation of emerging chemical threats and address key national and global health risks. The outcomes include the first spatial and temporal distribution of new emerging chemical threats in Australia.Read moreRead less
Understanding how an old heart gets stiff. Aging is accompanied by a stiffening of the heart and reduced function, which is accelerated by cardiovascular disease and leads to heart failure. How the heart stiffens is poorly understood. A new mechanism is proposed here, involving structural membrane proteins (termed caveolae and cavins) and a signalling molecule (nitric oxide). The current research aims to unravel the interplay between cardiac cells and these proteins/signals to cause stiffness an ....Understanding how an old heart gets stiff. Aging is accompanied by a stiffening of the heart and reduced function, which is accelerated by cardiovascular disease and leads to heart failure. How the heart stiffens is poorly understood. A new mechanism is proposed here, involving structural membrane proteins (termed caveolae and cavins) and a signalling molecule (nitric oxide). The current research aims to unravel the interplay between cardiac cells and these proteins/signals to cause stiffness and to determine whether this process governs normal aging of the heart. This work will advance understanding of how heart function is determined and reveal how the human heart changes with normal aging. Read moreRead less
Generalised Degrees of Freedom and Probabilistic Regularisation. This project intends to develop novel statistical tools for more accurate prediction by taking account of model complexity and uncertainties associated with the fitting procedure. The project also plans to develop a novel shrinkage approach via new penalty functions to avoid over-fitting and asymptotic properties. The key applications may include genetic studies where the number of predictors is large and biological experiments whe ....Generalised Degrees of Freedom and Probabilistic Regularisation. This project intends to develop novel statistical tools for more accurate prediction by taking account of model complexity and uncertainties associated with the fitting procedure. The project also plans to develop a novel shrinkage approach via new penalty functions to avoid over-fitting and asymptotic properties. The key applications may include genetic studies where the number of predictors is large and biological experiments where multivariate and temporal data are often collected – for example economical breeding in animal and fish farming and more effectively detecting the genes of interest in genetic studies on human, animals and plants.Read moreRead less
A dynamic model of work-related effort, recovery, and affective well-being. The aim of this project is to develop and test a computational model of work-related effort and recovery that explains how people recover from work demands moment-to-moment and day-to-day. Recovery is essential for well-being. Paradoxically, however, those who need to recover find it hard to put effort into recovery. The model will be tested in a series of naturalistic observational studies and controlled experiments. In ....A dynamic model of work-related effort, recovery, and affective well-being. The aim of this project is to develop and test a computational model of work-related effort and recovery that explains how people recover from work demands moment-to-moment and day-to-day. Recovery is essential for well-being. Paradoxically, however, those who need to recover find it hard to put effort into recovery. The model will be tested in a series of naturalistic observational studies and controlled experiments. In each study, subjective and physiological experiences of well-being and recovery are measured as people regulate effort during work and recovery. The result will be a unifying and general model of work recovery, that can inform when and how to intervene to improve employee well-being.Read moreRead less
Uncovering New Mechanisms of Metabolite-Sensing and Signaling. This project aims to understand how cells sense changes in metabolic activity, to ensure energy demands are matched with nutrient supply. Our proposal will fill critical gaps in our understanding of the molecular mechanisms underlying metabolic sensing. This will generate new knowledge with far reaching potential for Australian industries that rely on the propagation and utilization of living organisms, including agriculture, biotech ....Uncovering New Mechanisms of Metabolite-Sensing and Signaling. This project aims to understand how cells sense changes in metabolic activity, to ensure energy demands are matched with nutrient supply. Our proposal will fill critical gaps in our understanding of the molecular mechanisms underlying metabolic sensing. This will generate new knowledge with far reaching potential for Australian industries that rely on the propagation and utilization of living organisms, including agriculture, biotechnology and brewing, as well as knowledge relevant to sporting performance and the metabolic dimensions of ageing. This project will support advanced training of early career researchers and PhD students, which will expand Australian research capabilities and contribute to a producing a highly skilled workforce.Read moreRead less
Uncovering the coping toolbox for social and academic resilience in youth. This project aims to provide important new knowledge on youth stress, life adversity and coping to assist the development of efficient and successful resilience programs. Coping with stress is the number one concern of today's Australian teenagers. The project intends to address coping flexibility and resilience across the transition of youth from primary to secondary school and through the final years of secondary school ....Uncovering the coping toolbox for social and academic resilience in youth. This project aims to provide important new knowledge on youth stress, life adversity and coping to assist the development of efficient and successful resilience programs. Coping with stress is the number one concern of today's Australian teenagers. The project intends to address coping flexibility and resilience across the transition of youth from primary to secondary school and through the final years of secondary school. Expected outcomes include findings that can be translated into interventions that can assist individuals coping with life transitions at any age and those facing significant social, medical, workplace or academic stressors in other times of their life.Read moreRead less
Pluses and minuses of lipid mass spectrometry. This project aims to investigate the structural diversity of lipids. Lipids are among the most structurally diverse of all the biomolecules and thus deciphering their many functions requires bio-analytical technologies capable of uniquely identifying and quantifying individual molecules in a milieu of many thousands of analogues. Mass spectrometry is the pre-eminent technique for contemporary lipid analysis but is challenged by the preference of cer ....Pluses and minuses of lipid mass spectrometry. This project aims to investigate the structural diversity of lipids. Lipids are among the most structurally diverse of all the biomolecules and thus deciphering their many functions requires bio-analytical technologies capable of uniquely identifying and quantifying individual molecules in a milieu of many thousands of analogues. Mass spectrometry is the pre-eminent technique for contemporary lipid analysis but is challenged by the preference of certain lipids to ionise with a polarity that affords sensitive detection but does not permit detailed structure elucidation. This project will develop advanced instrumentation capable of on-demand polarity switching of ionised lipids such that the detection and interrogation of molecular structure can take place in the optimal charge state.Read moreRead less
Child Dental Benefit Policies and the Health of Australian Children. This project aims to examine the early effects of two recent initiatives by the Australian government to improve children’s dental health by providing funds to cover essential dental services for children from disadvantaged families. It explores the factors affecting eligible children’s access to benefits from these initiatives and identifies the causal impacts of these changed health care financing arrangements on children’s c ....Child Dental Benefit Policies and the Health of Australian Children. This project aims to examine the early effects of two recent initiatives by the Australian government to improve children’s dental health by providing funds to cover essential dental services for children from disadvantaged families. It explores the factors affecting eligible children’s access to benefits from these initiatives and identifies the causal impacts of these changed health care financing arrangements on children’s consumption of dental services, indicators of oral health and general health, and other indicators of cognitive and non-cognitive development. Using advanced econometric techniques and panel datasets, this project is expected to contribute to the development of effective policies for promoting health and wellbeing.Read moreRead less
Structural and neural determinants of stress and strain in human muscle. This project aims to further our understanding of the biomechanical stress and strains experienced by contracting human muscles. Using innovative imaging techniques such as microendoscopy and supersonic shear imaging, we expect to generate new significant evidence on the structural and neural factors that lead to areas of high stress in human muscles. Outcomes of this project include not only a new understanding of muscle d ....Structural and neural determinants of stress and strain in human muscle. This project aims to further our understanding of the biomechanical stress and strains experienced by contracting human muscles. Using innovative imaging techniques such as microendoscopy and supersonic shear imaging, we expect to generate new significant evidence on the structural and neural factors that lead to areas of high stress in human muscles. Outcomes of this project include not only a new understanding of muscle design on multi-scale level, but also of muscle function and adaptation. This should provide significant benefits in better predicting muscle injury and prescribing safe exercise, knowledge that would benefit biomechanical engineers and sport and exercise professionals.Read moreRead less