Reimagining strengths approaches to drug and alcohol care for young people. This project aims to advance the conceptualisation and practical application of strengths-based approaches in the youth alcohol and drug sector. These approaches provide a promising way forward for addressing substance use and disadvantage among young people, and are widespread in the sector, but lack a strong evidence base. The project will learn from excellence in Aboriginal strengths-based models, and draw on sociolog ....Reimagining strengths approaches to drug and alcohol care for young people. This project aims to advance the conceptualisation and practical application of strengths-based approaches in the youth alcohol and drug sector. These approaches provide a promising way forward for addressing substance use and disadvantage among young people, and are widespread in the sector, but lack a strong evidence base. The project will learn from excellence in Aboriginal strengths-based models, and draw on sociological frameworks, to generate evidence on which to build more relevant responses for disadvantaged young people. This will provide significant benefit to service providers and policymakers by providing evidence about how to do strengths-based practice that is responsive to the needs of disadvantaged young people.Read moreRead less
From causative genes to establishing therapies for patients with neuromuscular diseases. A major focus of this project will be pursuing multiple therapeutic approaches for a class of skeletal muscle diseases, which are most often severe and lethal within the first year of life. It will also hunt down the defective genes in human patients with other neuromuscular diseases and explore how these cause disease.
Unlocking bacterial shapeshifting and its role in antimicrobial resistance. This project aims to combine advanced imaging with innovative microfluidics to identify how microbial shapeshifting can be exploited as a target for new antimicrobials. Infections that are hard to treat due to increasing antimicrobial resistance not only have an enormous, global impact on mammalian health, including livestock and humans, but also carry a growing economic burden. Advanced understanding of microbial life c ....Unlocking bacterial shapeshifting and its role in antimicrobial resistance. This project aims to combine advanced imaging with innovative microfluidics to identify how microbial shapeshifting can be exploited as a target for new antimicrobials. Infections that are hard to treat due to increasing antimicrobial resistance not only have an enormous, global impact on mammalian health, including livestock and humans, but also carry a growing economic burden. Advanced understanding of microbial life can propel urgently needed progress this area. Specifically, the project outcomes are expected to aid the development of next generation antibiotics. The new fundamental knowledge should also benefit translational prevention, identification and management efforts of a rising national and global health threat.Read moreRead less
Changing the lives of young Australians with emotional disorders using a simple three-step treatment based on cognitive-neuroscience insights. Anxiety and depression are emotional disorders that affect many Australian children and place them at risk of lifelong impairment. The latest evidence from cognitive science and neuroscience shows that these children have maladaptive thinking strategies that lead to avoidance and withdrawal. Capitalising on these basic science insights, this project exami ....Changing the lives of young Australians with emotional disorders using a simple three-step treatment based on cognitive-neuroscience insights. Anxiety and depression are emotional disorders that affect many Australian children and place them at risk of lifelong impairment. The latest evidence from cognitive science and neuroscience shows that these children have maladaptive thinking strategies that lead to avoidance and withdrawal. Capitalising on these basic science insights, this project examines a new treatment, referred to as the 'Emotional Flexibility Program', that targets childhood distress in three simple steps over just four weeks of treatment. This treatment could change the way childhood emotional disorders are treated and prevented, improve the quality of life for thousands of young Australians, and offset the associated economic burden of disease.Read moreRead less
Understanding genetic and environmental risks of emotional disorders in childhood and adolescence. To reduce the burden of mental health disorders in Australia, this project will advance knowledge on genetic and environmental causes of anxiety and related disorders in children and adolescents. The results will allow better identification of children at risk for emotional problems and will identify new ways of tailoring prevention and treatment.
Modelling the population impact of injury. This project aims to model the long-term, population impact of non-fatal injury through the use of cutting edge epidemiological modelling, sophisticated biostatistics, advanced econometrics, and geospatial analysis. The project will use population-based, linked longitudinal data to generate new knowledge about the long-term impacts of injury, cost of injury, and expected burden into the future. Through the multi-disciplinary and multi-national collabo ....Modelling the population impact of injury. This project aims to model the long-term, population impact of non-fatal injury through the use of cutting edge epidemiological modelling, sophisticated biostatistics, advanced econometrics, and geospatial analysis. The project will use population-based, linked longitudinal data to generate new knowledge about the long-term impacts of injury, cost of injury, and expected burden into the future. Through the multi-disciplinary and multi-national collaborations established, it is anticipated that this project may lead to future changes in public health and social policy, prioritisation of injury prevention efforts, and establish the capacity to evaluate injury interventions and policy shifts as they occur.Read moreRead less
Improving quality of life in chronic aphasia: reducing depression and increasing social connection and life participation through community aphasia groups. Aphasia, a communication disability resulting from brain injury and experienced by over 80,000 Australians, impacts significantly on social connection, well being and mental health. This program of research defines excellent community aphasia groups, an important preventative health measure and investigates their impact for Australians with a ....Improving quality of life in chronic aphasia: reducing depression and increasing social connection and life participation through community aphasia groups. Aphasia, a communication disability resulting from brain injury and experienced by over 80,000 Australians, impacts significantly on social connection, well being and mental health. This program of research defines excellent community aphasia groups, an important preventative health measure and investigates their impact for Australians with aphasiaRead moreRead less
The development of the social brain in early childhood. This project aims to understand how the human brain develops social and emotional understanding. The brain has remarkable abilities for understanding our social environment, such as inferring other people’s thoughts and feelings. This project will use neuroscience techniques to investigate how brain networks combine to produce social understanding, how this changes throughout child development, and how it relates to complex social behaviour ....The development of the social brain in early childhood. This project aims to understand how the human brain develops social and emotional understanding. The brain has remarkable abilities for understanding our social environment, such as inferring other people’s thoughts and feelings. This project will use neuroscience techniques to investigate how brain networks combine to produce social understanding, how this changes throughout child development, and how it relates to complex social behaviours. This project’s findings could be used to develop educational programmes that enhance empathy and co-operation, strengthen family relationships, promote social inclusion and reduce maladaptive behaviours. It could also guide intervention in brain disorders that affect social understanding.Read moreRead less
Improving workplace productivity via an AI-based physical activity chatbot . This project aims to develop, train and evaluate a physical activity chatbot using artificial intelligence and machine learning to improve workplace productivity in sedentary office workers. Productivity losses, due to high numbers of physically inactive workers, cost the Australian economy $14 billion per year. The cost of effective and scalable workplace physical activity programs acts as a barrier to their implementa ....Improving workplace productivity via an AI-based physical activity chatbot . This project aims to develop, train and evaluate a physical activity chatbot using artificial intelligence and machine learning to improve workplace productivity in sedentary office workers. Productivity losses, due to high numbers of physically inactive workers, cost the Australian economy $14 billion per year. The cost of effective and scalable workplace physical activity programs acts as a barrier to their implementation. As such, innovative programs that can reach large numbers of workers at minimal cost are needed. This project aims to generate new knowledge on the use of artificial intelligence to achieve behavioural improvements and will lead to the development of a new type of behaviour change program with broad applicability.
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Statistical Modelling in the Era of Data Science: Theory and Practice. This project aims to develop innovative statistical methodology that is interpretable, theoretically justified, and scalable to today's growing complex data. With the influx of data being collected in both the public and private sectors, making sense of this data is a fundamental task. Through a rigorous modelling framework, this project intends to facilitate the discovery of knowledge by developing powerful new tools to extr ....Statistical Modelling in the Era of Data Science: Theory and Practice. This project aims to develop innovative statistical methodology that is interpretable, theoretically justified, and scalable to today's growing complex data. With the influx of data being collected in both the public and private sectors, making sense of this data is a fundamental task. Through a rigorous modelling framework, this project intends to facilitate the discovery of knowledge by developing powerful new tools to extract insight from these complex datasets. The outcomes of this project will benefit society by providing techniques to enable research advances and inform decision-making for a broad base of disciplines, including applications to network security, energy forecasting, environmental monitoring, and public health. Read moreRead less