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Advanced macromolecular engineering: novel approaches to self-directed assembly and vesicle formation. The aim of this project is to develop new approaches in nanotechnology for the preparation of well-defined polymeric particles. The research will result in the development of new methodology which has the potential to impact areas of commercial interest including those in the health-care sector.
Highly ordered and tunable extracellular DNA micro- and nanopatterns for investigating the attachment mechanisms of pseudomonas aeruginosa to surfaces. Preventing infectious bacteria from colonising artificial surfaces is a major scientific challenge. New engineered surfaces will be designed to better understand how the important pathogen Pseudomonas aeruginosa sticks to surfaces, facilitating new ways of reducing infections acquired from the surface of, for example, medical devices.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100012
Funder
Australian Research Council
Funding Amount
$890,000.00
Summary
Dual Column-Focused Ion Beam/Scanning Electron Microscope facility for Queensland. Dual column focused ion beam/scanning electron microscope facility: This facility will precisely cut specimens and surfaces that can be imaged in a variety of ways, including crystallographic and elemental space, of particular use for physical scientists, as well as biological specimens. This instrument will provide information at resolutions between optical and transmission electron microscopy, images that will ....Dual Column-Focused Ion Beam/Scanning Electron Microscope facility for Queensland. Dual column focused ion beam/scanning electron microscope facility: This facility will precisely cut specimens and surfaces that can be imaged in a variety of ways, including crystallographic and elemental space, of particular use for physical scientists, as well as biological specimens. This instrument will provide information at resolutions between optical and transmission electron microscopy, images that will effectively provide the biologist with the ability to develop the complete correlative picture of organelles and cells. The instrument will also provide a much needed resource for researchers across disciplines such as physics, chemistry, biology, geology and engineering.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101308
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
An in vitro model of biomaterial-induced thrombosis. This project intends to use bioengineering strategies to develop new methods to understand material interactions with proteins and cells. The project plans to develop microfluidic channels to contain test materials and immobilise a key enzyme associated with thrombosis by plasma immersion ion implantation. This knowledge may increase our understanding of material-biomolecule interactions and have implications for manipulating biological foulin ....An in vitro model of biomaterial-induced thrombosis. This project intends to use bioengineering strategies to develop new methods to understand material interactions with proteins and cells. The project plans to develop microfluidic channels to contain test materials and immobilise a key enzyme associated with thrombosis by plasma immersion ion implantation. This knowledge may increase our understanding of material-biomolecule interactions and have implications for manipulating biological fouling across multiple fields.Read moreRead less
Elucidating surface-mediated permissive cues for cellular differentiation. This project will develop a novel biomaterial platform technology that will enable firstly the probing and thereafter the control of the cellular pathways of adult mesenchymal stem cells. These fundamental insights will be translated into novel stem cell culture ware products that will enable clinically relevant, functional tissue repair and regeneration.
Directional fluid-transfer in thin porous materials with gradient wettability through thickness. This project will further strengthen Australia's world leading position in advanced fibrous materials research. It will provide a new platform technology to develop self-driven unidirectional fluid-transfer fabrics and porous membranes for diverse applications in daily life, healthcare, defence and a number of industrial processes.
Scalable and Applicable Nanostructured Adsorbents for Arsenic Removal with High Performance. Arsenic contamination in groundwater and drinking water affects over 100 million people worldwide and causes severe health problems. This project aims to use a recently patented technology to develop a new generation of adsorbents with controlled nanostructure and morphology for arsenic removal. The novel low-cost adsorbents are expected to have superior performance for the treatment of water containing ....Scalable and Applicable Nanostructured Adsorbents for Arsenic Removal with High Performance. Arsenic contamination in groundwater and drinking water affects over 100 million people worldwide and causes severe health problems. This project aims to use a recently patented technology to develop a new generation of adsorbents with controlled nanostructure and morphology for arsenic removal. The novel low-cost adsorbents are expected to have superior performance for the treatment of water containing arsenic at both high and low concentrations. The engineered products will be tested in high-throughput wastewater treatment in pharmaceutical factories and as a household drinking water treatment device. This project aims to bring economic and social benefits to Australian industry and improve the quality of life for people all over the world.Read moreRead less
Development of high-performance lead-free piezoelectric superlattices for environmentally-friendly and biocompatible piezoelectric micromachined ultrasonic transducers (pMUTs) applications. This program is aimed at development of environmentally friendly and biocompatible lead-free piezoelectric thin films and superlattices for the potential applications in pMUTs. The expected outcome includes deposition of BNT and BZT-based thin films and superlattices, and enhancement of their physical propert ....Development of high-performance lead-free piezoelectric superlattices for environmentally-friendly and biocompatible piezoelectric micromachined ultrasonic transducers (pMUTs) applications. This program is aimed at development of environmentally friendly and biocompatible lead-free piezoelectric thin films and superlattices for the potential applications in pMUTs. The expected outcome includes deposition of BNT and BZT-based thin films and superlattices, and enhancement of their physical properties by strain and interface engineering.Read moreRead less
Early-Stage Medical Diagnostics by Plasmon-Mediated Gas Sensing. This project will investigate the use plasmonic absorption of light in metal nanostructures to activate the selective oxidation/reduction of a gas molecule on a semiconductor nanoparticle. This concept will be used with the aim of developing a sensing technique capable of measuring ultra-low concentrations (ppb) of breath markers for lung cancer detection. It is expected that porous sensing films of semiconductor and metal nanopart ....Early-Stage Medical Diagnostics by Plasmon-Mediated Gas Sensing. This project will investigate the use plasmonic absorption of light in metal nanostructures to activate the selective oxidation/reduction of a gas molecule on a semiconductor nanoparticle. This concept will be used with the aim of developing a sensing technique capable of measuring ultra-low concentrations (ppb) of breath markers for lung cancer detection. It is expected that porous sensing films of semiconductor and metal nanoparticles with well-defined light absorption properties will be fabricated. Superior selectivity will be achieved by matching the wavelength of the absorbed light with the required activation energy for oxidation/reduction. Successful outcomes will enable multi-analyte fingerprint identification by on-chip devices with applications ranging from portable medical diagnostics to national security.Read moreRead less
Combating Antimicrobial Resistance with Bismuth, Gallium and Indium. This research project focuses on the design, development, and application of new bismuth, gallium and indium compounds as antimicrobial agents. These metals act as iron mimics in vivo and can exert antimicrobial activity while displaying low systemic toxicity in humans. The project aims to exploit this, and the inability of microbes to easily develop resistance towards metals, to combat bacteria for which modern drugs are rapid ....Combating Antimicrobial Resistance with Bismuth, Gallium and Indium. This research project focuses on the design, development, and application of new bismuth, gallium and indium compounds as antimicrobial agents. These metals act as iron mimics in vivo and can exert antimicrobial activity while displaying low systemic toxicity in humans. The project aims to exploit this, and the inability of microbes to easily develop resistance towards metals, to combat bacteria for which modern drugs are rapidly becoming ineffective, as highlighted in the WHO and US Centre for Disease Control list of critical and priority pathogens. The intended outcome is that efficacy will be driven through advances in synthetic and structural chemistry, discovering the mode of action, and creating anti-infective coatings and hydrogels.Read moreRead less