The Bacterial Type IX Secretion System In Polymicrobial Dysbiosis And Chronic Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$1,900,000.00
Summary
Periodontitis (severe gum disease) affects 1 in 3 adults and has been linked with heart attacks, cancer and dementia. I will lead a multidisciplinary team investigating the interaction between disease causing bacteria in the mouth and the immune response which results in destruction of the tooth’s supporting tissues and allows bacteria to enter the blood stream. The expected outcome is the development of a novel therapy which will stop progression of disease associated with these pathogens.
Generating Evidence For A Strong Foundation: Using Population Health Data For Translational Child Health, Healthcare And Policy
Funder
National Health and Medical Research Council
Funding Amount
$1,500,000.00
Summary
Professor Natasha Nassar’s research program uses advanced research methods to address new challenges in child population health. She will investigate the role and impact of early life factors, paediatric healthcare practices and long-term morbidity and survivorship on child health and development. Identification of at-risk children and involvement of clinicians and policy-makers in research will ensure improved child population health and development and healthy start to life for all children.
Innovation For Health Service Provision And Clinical Management Of Cardiovascular Disease Prevention
Funder
National Health and Medical Research Council
Funding Amount
$1,338,220.00
Summary
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality globally and had a steep rise in burden in low- and middle income countries. A greater focus on a preventative model of care is needed. Frugal innovation is the concept of creating small, low-cost solutions to big problems. My goal is to discover and robustly evaluate in real-world setting low-cost interventions that can be scaled and implemented to reduce the burden of CVD globally.
LIFESPAN-CHD – Leading Innovation By Finding And Eliminating Gaps In Research, SPecialist Care ANd Mental Health Services For People With CHD.
Funder
National Health and Medical Research Council
Funding Amount
$462,644.00
Summary
Keeping patients and families engaged in congenital heart disease (CHD) care is vital for improving health outcomes for Australians living with CHD. This collaboration will position Australia at the forefront of CHD care and research by delivering healthcare innovations including a national CHD health services dataset, a digital health tool that maximises engagement in CHD care and new models of care co-designed with CHD patients and families to meet their cardiac and mental health needs.
Transforming Approaches To Chronic Disease Prevention In Community Settings
Funder
National Health and Medical Research Council
Funding Amount
$2,738,220.00
Summary
Chronic disease is the leading cause of death in Australia. Research has identified a number of interventions to prevent chronic disease. However, most of these are impractical, difficult to implement and so have little impact in improving community health. In this research program I will generate evidence that is relevant for policy makers and practitioners, identifying effective interventions that can feasibly be delivered, and effective approaches to implement them in community settings.
Improving Diabetes-related Health Outcomes With Aboriginal And Torres Strait Islander People Across The Lifecourse
Funder
National Health and Medical Research Council
Funding Amount
$2,567,932.00
Summary
Aboriginal and Torres Strait Islander people bear a disproportionate burden of type 2 diabetes at all ages. My program of work aims to slow the progression of type 2 diabetes in Aboriginal and Torres Strait Islander children, through early-life prevention: pre-conception, pregnancy, childhood. I lead a partnership of researchers, health services and policy makers across Australia to improve diabetes-related health outcomes in Aboriginal and Torres Strait Islander communities.
Healthy Diet And Weight Management In Pregnancy: Evidence To Ease A Hefty Clinical Burden.
Funder
National Health and Medical Research Council
Funding Amount
$1,705,260.00
Summary
Approximately 50% of women are overweight or obese on entering pregnancy, placing women at increased risk of well documented pregnancy complications. This proposal will: 1) Translate RCT evidence into clinical practice to provide dietary advice for pregnant women 2) Address why pregnancy interventions have not impacted weight gain despite improved maternal diet 3) Consider the key features of an intervention before conception 4) Evaluate a pilot RCT weight loss intervention
Advancing The Radical Cure Of Plasmodium Vivax Malaria Through Optimal Antimalarial Regimens
Funder
National Health and Medical Research Council
Funding Amount
$566,164.00
Summary
Forty percent of the global population are at risk of vivax malaria and its associated morbidity. Complete cure of vivax malaria can result in severe anaemia caused by adverse effects of primaquine in vulnerable individuals. My research will provide important evidence for national malaria programs and clinicians, identifying the optimal dosing regimen across different ages and locations, that balances the risks and benefits of primaquine treatment.
Targeted Approaches To Improve Health Outcomes In Severe Respiratory Disease
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Despite receiving optimal treatment, people with severe lung disease experience distressing symptoms, reduced quality of life and wellbeing, and poor health outcomes. This transformational research will investigate new treatment approaches: an integrated palliative care program and Nasal High Flow therapy at home, to identify benefits for people with lung disease. Additionally this research will examine how patients’ attitudes to illness distress and mental health affect wellbeing and health
Driving Advances In Sugar-sweetened Beverage Policy And Resolving The Unknown Substitution Effects Into Artificially-sweetened Beverage, Fruit Juice And Water Consumption.
Funder
National Health and Medical Research Council
Funding Amount
$1,449,800.00
Summary
Many countries are introducing sugar sweetened beverages (SSBs) taxes and other policy measures to curb consumption. However, artificially sweetened beverages (ASBs) and fruit juices are being excluded from these policy measures. This may have unintended consequences for consumption behaviours and create other negative health outcomes. We will examine substitution effects of SSB policy on water, ASBs and fruit juice consumption, and make recommendations for public health policy.