Discovery Early Career Researcher Award - Grant ID: DE130100488
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Cellular dynamics of nanoengineered particles. Nanotechnology has the capacity to drive a new wave of biological innovation through engineering materials at the nanoscale. This project will advance understanding of how nanoengineered materials interact with biological systems to enable the development of nanomaterials for future translational research.
Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour ....Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour requirement, higher production rate and better quality control than conventional production methods. The new process will combine benefits from both supercritical fluid technology (green process) and microfluidics (high mass & heat transfer).Read moreRead less
High-resolution elastography – Using optical micro-imaging of tissue mechanics to identify disease. Optical elastography, the probing of tissue’s micro-mechanical properties using optical imaging, offers new tools in surgery and pathology to improve differentiation of tissues. This project lays the groundwork for optical elastography to become a new medical micro-imaging modality by removing impediments to progress in this rapidly emerging field. On the micro-scale, between the scales of cells a ....High-resolution elastography – Using optical micro-imaging of tissue mechanics to identify disease. Optical elastography, the probing of tissue’s micro-mechanical properties using optical imaging, offers new tools in surgery and pathology to improve differentiation of tissues. This project lays the groundwork for optical elastography to become a new medical micro-imaging modality by removing impediments to progress in this rapidly emerging field. On the micro-scale, between the scales of cells and organs. This project will elucidate the origins of tissue mechanical contrast and determine limits on its measurement. It will develop a suite of probes: noncontact, endoscopic and needle, to enable access to all tissues in the body. To progress toward a new modality and inform our research, the project will test our tools on breast cancer tissues and burn scars.Read moreRead less
Nanoscale silicon field-effect transistor diagnostic technology. This project aims to overcome barriers to the implementation of silicon field-effect transistor biosensors. It will investigate the biosensors’ physical and structural properties. This knowledge, combined with technological and conceptual advances, could foster the development of an advanced and translational point-of-care diagnostic technology to rapidly and sensitively detect malignant tissues. Such technology would have commerci ....Nanoscale silicon field-effect transistor diagnostic technology. This project aims to overcome barriers to the implementation of silicon field-effect transistor biosensors. It will investigate the biosensors’ physical and structural properties. This knowledge, combined with technological and conceptual advances, could foster the development of an advanced and translational point-of-care diagnostic technology to rapidly and sensitively detect malignant tissues. Such technology would have commercial potential and important societal benefits.Read moreRead less
Multi-modal virtual microscopy for quantitative diagnostic pathology. This project will contribute to the next generation of virtual microscopy systems that provide innovative features capable of significantly increasing the adoption of digital imaging technology throughout the field of diagnostic pathology. These tools will especially contribute to the screening and diagnosis of cervical, lung and bladder cancer.
A new tool for comprehensive label-free micro-imaging of cancer in situ. This project aims to engineer a new micro-imaging tool for comprehensive characterisation of the tumour microenvironment in situ, including micro-morphology, microvasculature, extracellular matrix, local stiffness and the functional variables of pH, oxygen content and temperature. The project will provide accessible, label-free longitudinal monitoring of tumours in animal models of disease; thereby, reducing animal use, imp ....A new tool for comprehensive label-free micro-imaging of cancer in situ. This project aims to engineer a new micro-imaging tool for comprehensive characterisation of the tumour microenvironment in situ, including micro-morphology, microvasculature, extracellular matrix, local stiffness and the functional variables of pH, oxygen content and temperature. The project will provide accessible, label-free longitudinal monitoring of tumours in animal models of disease; thereby, reducing animal use, improving experimental power, and providing better micro-scale characterisation to underpin discovery and application in cancer biology. With potential for translation to humans and commercialisation, such a tool will ultimately contribute to improved diagnosis and treatment of cancer.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100003
Funder
Australian Research Council
Funding Amount
$318,900.00
Summary
Vector network analyser suite for advanced terahertz materials and devices. This project aims to establish terahertz measurement capabilities to further Australia's strength and momentum in terahertz research. This will comprise of two terahertz extension modules, working with a dedicated vector-network analyser, and high-precision probes and probe station. The project will enable point-feeding, monochromatic, coherent, and fine spectral-resolution measurement at an atmospheric window of 220-330 ....Vector network analyser suite for advanced terahertz materials and devices. This project aims to establish terahertz measurement capabilities to further Australia's strength and momentum in terahertz research. This will comprise of two terahertz extension modules, working with a dedicated vector-network analyser, and high-precision probes and probe station. The project will enable point-feeding, monochromatic, coherent, and fine spectral-resolution measurement at an atmospheric window of 220-330 GHz. The capabilities are essential for development of two-dimensional materials, active components, waveguides, and antennas towards a common goal of efficient integrated terahertz devices and systems. The project will serve emerging terahertz applications including standoff imaging and short-range high-speed data transmission. This will have broad impact in the areas of surveillance, biomedicine, security, and public safety and well-being.Read moreRead less
Engineering high-efficiency all-dielectric antennas for terahertz channels. This project aims to create unconventional antenna platforms to support terahertz links. The project expects to deliver high-efficiency, high-gain dielectric resonator antennas and dielectric rod antenna arrays fed by dielectric wave-guides. The expected outcomes of this project will build critical components for future terahertz communication infrastructure. These antennas will support demands in point-to-point wireless ....Engineering high-efficiency all-dielectric antennas for terahertz channels. This project aims to create unconventional antenna platforms to support terahertz links. The project expects to deliver high-efficiency, high-gain dielectric resonator antennas and dielectric rod antenna arrays fed by dielectric wave-guides. The expected outcomes of this project will build critical components for future terahertz communication infrastructure. These antennas will support demands in point-to-point wireless transmission between mobile base stations, within data centres, and at information kiosks.Read moreRead less
Wideband Strongly-Truncated Composite Cavity-Resonator Antennas. A rapidly growing demand for fast wireless services calls for wideband communication systems with wideband antennas, which are compact, aesthetically appealing and inexpensive, yet have good performance. With novel concepts, this project aims to produce a new class of antennas that deliver impressive performance (bandwidth and gain) while taking up a dramatically reduced area in a way that was impossible before, increasing a figure ....Wideband Strongly-Truncated Composite Cavity-Resonator Antennas. A rapidly growing demand for fast wireless services calls for wideband communication systems with wideband antennas, which are compact, aesthetically appealing and inexpensive, yet have good performance. With novel concepts, this project aims to produce a new class of antennas that deliver impressive performance (bandwidth and gain) while taking up a dramatically reduced area in a way that was impossible before, increasing a figure-of-merit to up to seven times the state-of-the-art. Their planar geometry and simplicity lead to low cost. This is expected to create new knowledge, design methods and examples, prototypes, test results and guidelines required to design, optimise and make these versatile antennas for emerging robust broadband wireless systems.Read moreRead less
Silicon-Carbide Switches for Post-Silicon Efficiency of Power Electronics. The aim of this project is to create a prototype of a silicon carbide (SiC)-based power-electronic switch for improved energy efficiency and reduced size of power-electronic circuits, well beyond the theoretical limits of silicon technology. Until very recently, the dominant controlled switch in electronics could only be implemented as a silicon transistor. A new method of electronic passivation of SiC surfaces has enable ....Silicon-Carbide Switches for Post-Silicon Efficiency of Power Electronics. The aim of this project is to create a prototype of a silicon carbide (SiC)-based power-electronic switch for improved energy efficiency and reduced size of power-electronic circuits, well beyond the theoretical limits of silicon technology. Until very recently, the dominant controlled switch in electronics could only be implemented as a silicon transistor. A new method of electronic passivation of SiC surfaces has enabled the recent commercialisation of SiC transistors. It is expected that the material advantages of SiC can be fully exploited by a new device structure and a new fabrication process.Read moreRead less