New Strategies for Monitoring DNA-Anticancer Drug Interactions. The highly successful cisplatin works by binding to DNA and partially unwinding or bending the DNA. As a consequence of the success if cisplatin, alternative anticancer drugs are being developed with reduced side effects for patients. One of the bottom necks in the development of alternative drugs is rapid screening of the efficacy on new leads. The proposed research will develop new technologies for monitoring DNA-drug binding, ....New Strategies for Monitoring DNA-Anticancer Drug Interactions. The highly successful cisplatin works by binding to DNA and partially unwinding or bending the DNA. As a consequence of the success if cisplatin, alternative anticancer drugs are being developed with reduced side effects for patients. One of the bottom necks in the development of alternative drugs is rapid screening of the efficacy on new leads. The proposed research will develop new technologies for monitoring DNA-drug binding, DNA damage and DNA repair using novel DNA biosensors. the novelty of the biosensor technology will be to use the modulation of charge transfer through DNA as a method for determining the structural changes that occur in DNA due to these events occurring.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101518
Funder
Australian Research Council
Funding Amount
$345,000.00
Summary
Cellular responses to nanoparticles from cells on micropatterned surfaces. The mechanisms underlying cell-nanoparticle interactions remain largely unknown. It has hampered the design and development of innovative nano devices to be used for drug delivery, biomarkers and diagnostics. This project aims to explore the influences of cell size, density, geometry, intercellular communication and substrate properties on cell-nanoparticle interactions. A micropatterning technology is applied to precisel ....Cellular responses to nanoparticles from cells on micropatterned surfaces. The mechanisms underlying cell-nanoparticle interactions remain largely unknown. It has hampered the design and development of innovative nano devices to be used for drug delivery, biomarkers and diagnostics. This project aims to explore the influences of cell size, density, geometry, intercellular communication and substrate properties on cell-nanoparticle interactions. A micropatterning technology is applied to precisely control cell behaviour and provide a novel in vitro cellular model for nanoparticle studies. This project aims to significantly improve the understanding of cell-nanoparticle interactions to provide new insight into nanoparticle design and improve the efficacy of nano devices.Read moreRead less
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revol ....ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano-interface.Read moreRead less
Nanoscale silicon field-effect transistor diagnostic technology. This project aims to overcome barriers to the implementation of silicon field-effect transistor biosensors. It will investigate the biosensors’ physical and structural properties. This knowledge, combined with technological and conceptual advances, could foster the development of an advanced and translational point-of-care diagnostic technology to rapidly and sensitively detect malignant tissues. Such technology would have commerci ....Nanoscale silicon field-effect transistor diagnostic technology. This project aims to overcome barriers to the implementation of silicon field-effect transistor biosensors. It will investigate the biosensors’ physical and structural properties. This knowledge, combined with technological and conceptual advances, could foster the development of an advanced and translational point-of-care diagnostic technology to rapidly and sensitively detect malignant tissues. Such technology would have commercial potential and important societal benefits.Read moreRead less
Modelling applications of nanomaterials in biology and medicine. This proposal will address fundamental issues related to nanomaterials and their applications in biology and medicine. Accurate mathematical models will be formulated, leading to new practical techniques in nanobiotechnology, safe and effective methods to diagnose and cure diseases including cancer via targeted drug and gene delivery, and detection methods for biological hazards, such as those arising from biological terrorism. The ....Modelling applications of nanomaterials in biology and medicine. This proposal will address fundamental issues related to nanomaterials and their applications in biology and medicine. Accurate mathematical models will be formulated, leading to new practical techniques in nanobiotechnology, safe and effective methods to diagnose and cure diseases including cancer via targeted drug and gene delivery, and detection methods for biological hazards, such as those arising from biological terrorism. The research facility proposed involves significant training of applied mathematicians at honours, PhD and postdoctoral levels and multidisciplinary collaboration, ensuring that Australia maintains and develops an expertise in nanobiotechnology well into the future.Read moreRead less
Characterisation and Modelling of Nanostructured Soft Magnetic Materials for Advanced Electromagnetic Applications. This project bridges the gap between nanomagnetic materials and practical applications. The knowledge generated and the international collaborations with world class scientists established through this cutting-edge research project will strengthen the leading status of Australia in the field of nanoscience and nanotechnology. The research outcomes will stimulate the growth of world ....Characterisation and Modelling of Nanostructured Soft Magnetic Materials for Advanced Electromagnetic Applications. This project bridges the gap between nanomagnetic materials and practical applications. The knowledge generated and the international collaborations with world class scientists established through this cutting-edge research project will strengthen the leading status of Australia in the field of nanoscience and nanotechnology. The research outcomes will stimulate the growth of world class Australian industries and hence the national economy through the commercial manufacturing of hi-tech nanomagnetic materials and innovative smart devices and systems. High quality PhD and honours project students will be trained.Read moreRead less
Self-organised complex ionised gas systems for ordered nanometre-scale assemblies. This proposal is to develop the physical principles of nano-scale assembly processes in complex plasmas. Novel approaches for tailoring the plasma-grown building blocks and controllable deposition of ordered nanoparticle arrays on nanopatterned solids are targeted. The fundamentals of the multi-scale dynamic processes will be elucidated and existing techniques for developing new materials and electronic/photonic d ....Self-organised complex ionised gas systems for ordered nanometre-scale assemblies. This proposal is to develop the physical principles of nano-scale assembly processes in complex plasmas. Novel approaches for tailoring the plasma-grown building blocks and controllable deposition of ordered nanoparticle arrays on nanopatterned solids are targeted. The fundamentals of the multi-scale dynamic processes will be elucidated and existing techniques for developing new materials and electronic/photonic devices will be advanced. The expected outcomes are highly relevant for the nano-materials and optoelectronic technologies, rapidly emerging areas of high-tech industries worldwide.Read moreRead less
CNTs-modified polymer composites for tribological applications. The growth of the Australian economy relies on continuous improvements in all sectors of production, manufacturing, operation and management where tribology is playing a significant role. System failure relevant to wear and friction over years and its impact on the Australian economy have continued to be a challenge for the community in the new century. The project is at the forefront of materials research, and the outcomes will pro ....CNTs-modified polymer composites for tribological applications. The growth of the Australian economy relies on continuous improvements in all sectors of production, manufacturing, operation and management where tribology is playing a significant role. System failure relevant to wear and friction over years and its impact on the Australian economy have continued to be a challenge for the community in the new century. The project is at the forefront of materials research, and the outcomes will provide (1) novel technical ways to optimise tribological performance of industrial contacting components, and (2) development of new wear resistant materials. The project will give Australia a competitive edge in the advances of tribology and nanotechnologyRead moreRead less
Complex plasmas: self-organized dusty matter from nanotechnology to astrophysics. The importance of complex plasmas is based on their intricate self-organized behaviour, on their rich variety in nature and extensive use in the laboratory and advanced technologies. This project aims at breakthrough results advancing the fundamental knowledge and contributing to frontier technologies such as nanoelectronics and nanotechnology as well as reliability of space technological systems and communication ....Complex plasmas: self-organized dusty matter from nanotechnology to astrophysics. The importance of complex plasmas is based on their intricate self-organized behaviour, on their rich variety in nature and extensive use in the laboratory and advanced technologies. This project aims at breakthrough results advancing the fundamental knowledge and contributing to frontier technologies such as nanoelectronics and nanotechnology as well as reliability of space technological systems and communications. The project will boost fundamental and applied aspects of the Australian science as well as international collaborative links of Australian research and technology by allowing access and involvement to advanced multi-national programs and high-profile experiments such as those on board the International Space Station.Read moreRead less