Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour ....Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour requirement, higher production rate and better quality control than conventional production methods. The new process will combine benefits from both supercritical fluid technology (green process) and microfluidics (high mass & heat transfer).Read moreRead less
Using Drosophila to analyse a master regulator of epithelial homeostasis. Aims:
This proposal aims to use genetic and cell biological analysis of the vinegar fly, Drosophila, to identify the function of the grainyhead gene in intestinal regeneration.
Significance:
This gene is conserved in all animal species and appears to be a master regulator of epithelial tissue development but it is unclear how it can both influence stem cell maintenance and production of functional cell types.
Expected out ....Using Drosophila to analyse a master regulator of epithelial homeostasis. Aims:
This proposal aims to use genetic and cell biological analysis of the vinegar fly, Drosophila, to identify the function of the grainyhead gene in intestinal regeneration.
Significance:
This gene is conserved in all animal species and appears to be a master regulator of epithelial tissue development but it is unclear how it can both influence stem cell maintenance and production of functional cell types.
Expected outcomes:
We will identify a new mechanism that governs tissue development, and introduce new imaging and genetic technologies to the Australian research community.
Benefit:
We expect potential economic and commercial interest in development of new gene analysis tools and biotechnological tissue manipulation applications.Read moreRead less
Micro-dissection of clathrins role in mitosis via chemical biology probes. This project aims to contribute to understanding the molecular mechanisms of the role of a key protein, clathrin, in cell division. In doing so it expects to reveal new approaches to stop uncontrolled cell division and proliferation, the hallmarks of cancer. The outcomes could in the long term inform breakthroughs in cancer treatment, significant enhancements in life quality and a reduction in cancer death rates.
Sustainable Mathematical Foundations: STEM-enriched Modelling . This longitudinal project aims to generate new knowledge on how sustainable, innovative mathematics learning can be fostered through STEM-enriched mathematical modelling across the early grades. Featuring interdisciplinary processes, including engineering and science, novel modelling sequences will prompt children to adapt their existing ways of mathematical thinking to develop conceptual innovations in solving future-oriented pr ....Sustainable Mathematical Foundations: STEM-enriched Modelling . This longitudinal project aims to generate new knowledge on how sustainable, innovative mathematics learning can be fostered through STEM-enriched mathematical modelling across the early grades. Featuring interdisciplinary processes, including engineering and science, novel modelling sequences will prompt children to adapt their existing ways of mathematical thinking to develop conceptual innovations in solving future-oriented problems. New theoretical and empirical frameworks are expected to transform our outmoded problem experiences to ones that challenge all children to reach their mathematical potential. Professional learning, informed by international collaboration, is expected to transcend existing teacher development modes.Read moreRead less
Talking Maths: Bridging the gap through talk in Early Years mathematics . The study aims to address the gap in mathematical performance in Australia in relation to socioeconomic status (SES) by focusing on language and learning in mathematics. The study will design and evaluate a school-based intervention that positions language through talk as a key resource in teaching mathematics in Grades 1 and 2. Outcomes of the study will be empirical evidence of the effect of a language-based pedagogy on ....Talking Maths: Bridging the gap through talk in Early Years mathematics . The study aims to address the gap in mathematical performance in Australia in relation to socioeconomic status (SES) by focusing on language and learning in mathematics. The study will design and evaluate a school-based intervention that positions language through talk as a key resource in teaching mathematics in Grades 1 and 2. Outcomes of the study will be empirical evidence of the effect of a language-based pedagogy on young students' achievement in mathematics and further understanding of the relationship between talk and learning. These outcomes will inform policy and teacher education and have a long lasting impact on low SES students' educational and work opportunities with ultimate impact on economic and cultural prosperity.
Read moreRead less
Using immersive virtual reality to enhance students’ science visualisation. This project aims to investigate the potential of advanced visualisation technology, immersive virtual reality, as a collaborative learning environment to support students to explore their ideas and learn a core chemistry concept, molecular structures and functions. Incorporating both data analytics and qualitative video analysis, the project will establish a deep understanding of how students learn about the molecular w ....Using immersive virtual reality to enhance students’ science visualisation. This project aims to investigate the potential of advanced visualisation technology, immersive virtual reality, as a collaborative learning environment to support students to explore their ideas and learn a core chemistry concept, molecular structures and functions. Incorporating both data analytics and qualitative video analysis, the project will establish a deep understanding of how students learn about the molecular world within an immersive virtual reality environment in relation to the learners’ experience, chemistry content, visual representations, learning tasks, and design features. The project will recommend evidence-driven design considerations for learning resources development and further educational research with advanced technologies.Read moreRead less
Enabling students' critical mathematical thinking. The capacity to use mathematics critically is essential for making prudent decisions and forming balanced judgements about economic, health, environmental and other challenges facing society. Developing Critical Mathematical Thinking (CMT) in the classroom provides students with the necessary skills to address complex real-world problems. Fostering CMT, however, is difficult and teaching practices around its development are under-researched and ....Enabling students' critical mathematical thinking. The capacity to use mathematics critically is essential for making prudent decisions and forming balanced judgements about economic, health, environmental and other challenges facing society. Developing Critical Mathematical Thinking (CMT) in the classroom provides students with the necessary skills to address complex real-world problems. Fostering CMT, however, is difficult and teaching practices around its development are under-researched and under-theorised. This study aims to generate new insight into teaching practices that can promote or inhibit students' CMT development. To address this aim, we use an innovative video-based methodology that integrates researcher and teacher perspectives on students' CMT development.Read moreRead less
Enriching mathematics and science learning: an interdisciplinary approach. This international, longitudinal project aims to investigate the effectiveness of an innovative interdisciplinary learning approach in mathematics and science. Through collaborating primary schools in Australia and the United States of America (USA), it will investigate how students’ invention and transformation of representational systems can connect to support deeper reasoning and learning. The project will form the ba ....Enriching mathematics and science learning: an interdisciplinary approach. This international, longitudinal project aims to investigate the effectiveness of an innovative interdisciplinary learning approach in mathematics and science. Through collaborating primary schools in Australia and the United States of America (USA), it will investigate how students’ invention and transformation of representational systems can connect to support deeper reasoning and learning. The project will form the bases for new curricular designs that leverage students’ representational practices across science, technology, engineering and mathematics (STEM) disciplines to promote more robust and generative knowledge.Read moreRead less
Primary teachers' adaptive expertise in interdisciplinary maths and science. This project aims to investigate the development of primary teachers’ adaptive expertise in interdisciplinary mathematics and science. As a critical component of quality teaching, adaptive expertise is essential for teachers to innovate their teaching to enhance student learning and interest, yet little is known about its development. The project aims to explore how adaptive expertise can be fostered through classroom i ....Primary teachers' adaptive expertise in interdisciplinary maths and science. This project aims to investigate the development of primary teachers’ adaptive expertise in interdisciplinary mathematics and science. As a critical component of quality teaching, adaptive expertise is essential for teachers to innovate their teaching to enhance student learning and interest, yet little is known about its development. The project aims to explore how adaptive expertise can be fostered through classroom innovations purposefully co-designed by teachers and researchers in the context of interdisciplinary mathematics and science. Expected outcomes include a better theoretical understanding of adaptive expertise in the context of interdisciplinary mathematics and science to benefit teacher learning and improve student outcomes.Read moreRead less
Equity and spatial reasoning in students’ mathematics development. The project aims to understand the influence of Spatial-Reasoning on school mathematics. Spatial-Reasoning skills are a significant predictor of achievement in mathematics, and will become increasingly necessary in digital and dynamic environments. Opportunities for disadvantaged students to develop such reasoning skills are limited; they are typically not taught in schools. The project investigates the role and nature of Spatial ....Equity and spatial reasoning in students’ mathematics development. The project aims to understand the influence of Spatial-Reasoning on school mathematics. Spatial-Reasoning skills are a significant predictor of achievement in mathematics, and will become increasingly necessary in digital and dynamic environments. Opportunities for disadvantaged students to develop such reasoning skills are limited; they are typically not taught in schools. The project investigates the role and nature of Spatial-Reasoning in students’ mathematics development; and substantiates the long-term effect of a spatial learning programme on educationally disadvantaged students’ mathematics performance and reasoning. This project is expected to improve disadvantaged students’ spatial reasoning and mathematics skills and their life opportunities.Read moreRead less