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MicroRNA Pathway Control Of Immune Cell Development
Funder
National Health and Medical Research Council
Funding Amount
$631,370.00
Summary
The immune system is comprised of many different cell types, each with a specialised function. Many are short-lived and must be continually replenished throughout life. Abnormalities in this process underlie many human diseases, including immunodeficiency, autoimmunity and cancer. My laboratory seeks to understand the molecular pathways that control development of immune cells and to identify the defects that lead to disease.
The Role Of Oncogenes, Cell Death Machinery And Novel Players In The Regulation Of Hematopoietic Stem Cells, Leukemogenesis And Hematological Disorders
Funder
National Health and Medical Research Council
Funding Amount
$763,409.00
Summary
This project is focused on the regulation of blood cells and the diseases that arise when they become defective, such as bone marrow failure and leukemia. It will investigate how proteins involved in cell suicide impact on blood cell survival, cancer therapy, and the formation of blood clots. The link between cancer genes and stem cells will be examined. Ultimately, the aims are to identify drug targets in hematological disorders, and develop new drugs to promote the survival of healthy cells.
Regulation Of Normal And Malignant Haematopoiesis By The Bone Marrow Environment
Funder
National Health and Medical Research Council
Funding Amount
$621,458.00
Summary
This project will identify factors within the bone marrow that regulate blood and immune cell formation. These include oxygenation and novel proteins identified in the applicant’s laboratory. How these factors from the bone marrow influence the behaviour of normal blood forming cells (called haematopoietic stem cells), and the progression of leukaemia and the response of leukaemia to chemotherapy treatments will be investigated. New drugs that interfere with these new factors will be tested for ....This project will identify factors within the bone marrow that regulate blood and immune cell formation. These include oxygenation and novel proteins identified in the applicant’s laboratory. How these factors from the bone marrow influence the behaviour of normal blood forming cells (called haematopoietic stem cells), and the progression of leukaemia and the response of leukaemia to chemotherapy treatments will be investigated. New drugs that interfere with these new factors will be tested for their potential to treat leukaemia.Read moreRead less
NHMRC Research Fellowship. Genetic Modification And Differentiation Of Human Pluripotent Stem Cells: Creating Tools For Regenerative Medicine And Models For Disease
Funder
National Health and Medical Research Council
Funding Amount
$757,297.00
Summary
Human embryonic stem cells (hESCs) can form all the cell types in the body. Cells made from hESCs could be used to test new drugs prior to trials in patients and eventually to replace tissues damaged through accident or disease. My laboratory is turning hESCs into blood, heart and insulin producing cells. We can genetically modify such that the cells fluoresce whenever they develop into these cell types. These 'glowing' hESC lines help us to make different cell types more efficiently.