Investigating the atomic structure of an immune cell inhibitory receptor. T cells play a key role in the adaptive immune system, whose reactivity must be controlled to prevent aberrant reactivity. Central to the function of T cells is the T cell antigen receptor, and a host of co-stimulatory molecules, co-receptors and inhibitory receptors. This proposal, in partnership with Immutep Ltd, aims to gain a basic understanding of the structure and function of a key inhibitory receptor found on T cel ....Investigating the atomic structure of an immune cell inhibitory receptor. T cells play a key role in the adaptive immune system, whose reactivity must be controlled to prevent aberrant reactivity. Central to the function of T cells is the T cell antigen receptor, and a host of co-stimulatory molecules, co-receptors and inhibitory receptors. This proposal, in partnership with Immutep Ltd, aims to gain a basic understanding of the structure and function of a key inhibitory receptor found on T cells, termed the Lymphocyte activation gene-3 (LAG-3). The proposal utilises a combination of cellular immunology and structural biology to gain insight into the form and function of the LAG-3 molecule. Ultimately this fundamental knowledge can be used by the biotechnology industry.Read moreRead less
Will genetic rescue save the Tasmanian devil? This project aims to measure the long-term genetic impacts of the Save the Tasmanian Devil Program’s ‘Wild Devil Recovery’ initiative. The project will determine whether supplementing small populations with individuals that are genetically diverse reduces inbreeding depression. The project will also monitor the impact of supplementation on the evolutionary trajectory of Devil Facial Tumour Disease. The project will train a cohort of conservation scie ....Will genetic rescue save the Tasmanian devil? This project aims to measure the long-term genetic impacts of the Save the Tasmanian Devil Program’s ‘Wild Devil Recovery’ initiative. The project will determine whether supplementing small populations with individuals that are genetically diverse reduces inbreeding depression. The project will also monitor the impact of supplementation on the evolutionary trajectory of Devil Facial Tumour Disease. The project will train a cohort of conservation scientists to translate genetic data into management actions. The outputs will directly inform the management actions of the Tasmanian Department of Primary Industries Parks, Water and the Environment and will help shape other species recovery programs.Read moreRead less
Increasing amphibian immunity to combat disease causing mass extinction. This project aims to increase amphibian survival to combat the devastating chytrid fungus by identifying resistance genes and increasing their frequency in the host population. The project is interdisciplinary and uses targeted genetic manipulation techniques developed for agriculture to improve disease resistance in wildlife for the first time. Expected outcomes include 1) enhanced international collaborations in comparati ....Increasing amphibian immunity to combat disease causing mass extinction. This project aims to increase amphibian survival to combat the devastating chytrid fungus by identifying resistance genes and increasing their frequency in the host population. The project is interdisciplinary and uses targeted genetic manipulation techniques developed for agriculture to improve disease resistance in wildlife for the first time. Expected outcomes include 1) enhanced international collaborations in comparative immunology, 2) a comprehensive understanding of immunity to chytridiomycosis, and 3) disease resistant amphibians. The anticipated benefit is ability to apply the optimal method to improve conservation of wildlife threatened by emerging disease, such as marker assisted selective breeding or genetic engineering.Read moreRead less