Deciphering the regulatory principles of metazoan development. This proposal aims to elucidate how regulatory elements in the genome, known as enhancers, determine the identity and function of animal tissues. Currently, it is believed that enhancers cannot be traced across evolutionarily distant animals. The project uses novel concepts, computational and molecular approaches to identify deeply conserved enhancers. It further dissects the mechanism of function by proteomics and high-throughput ge ....Deciphering the regulatory principles of metazoan development. This proposal aims to elucidate how regulatory elements in the genome, known as enhancers, determine the identity and function of animal tissues. Currently, it is believed that enhancers cannot be traced across evolutionarily distant animals. The project uses novel concepts, computational and molecular approaches to identify deeply conserved enhancers. It further dissects the mechanism of function by proteomics and high-throughput genomics. The expected outcomes will overturn our current view on enhancer evolution and reposition our understanding of how enhancers are functionally encoded in the genome. The work is an important contribution to understanding cellular complexity and species evolution with wide-ranging impact in genetics.Read moreRead less
Sustainable farming in Australia: Market instruments for improved land management. Sustainable farming has become a national priority. As climate change and global economic pressures increase the problems facing rural areas, Australian governments have attempted to combine more sustainable land management with a competitive agricultural sector. Several policy instruments using market incentives have been proposed to manage the competing demands of farm viability and environmental sustainability. ....Sustainable farming in Australia: Market instruments for improved land management. Sustainable farming has become a national priority. As climate change and global economic pressures increase the problems facing rural areas, Australian governments have attempted to combine more sustainable land management with a competitive agricultural sector. Several policy instruments using market incentives have been proposed to manage the competing demands of farm viability and environmental sustainability. This project will examine the responses of beef, dairy and grain farmers to these initiatives and their potential for addressing pressing environmental issues. The research will make a vital contribution to the design of policies for the future of farming, resilient rural communities and an environmentally sustainable Australia.Read moreRead less
The characterization of tiny Ribonucleic acids in animal epigenetics. Epigenetics, the inheritance of traits not encoded in deoxyribonucleic acid (DNA), is not well understood in animals. This project will investigate two classes of Ribonucleic acid (RNA) that may form part of an animal-specific epigenetic regulatory system. This study could revolutionize our understanding of animal genetics.