Long-term Implications And Outcomes Of Anti Hepatitis B Virus (HBV) Treatment In HIV-HBV Co-infection
Funder
National Health and Medical Research Council
Funding Amount
$293,931.00
Summary
Chronic hepatitis B (HBV) infection may cause serious liver disease in some people, including liver failure or liver cancer. Being infected with both HBV and HIV increases the chances of these complications occurring and the rate they develop. The optimal long term management of HIV-HBV co-infection remains unclear; and the effects of antiretroviral therapy on liver disease progression outcome is unknown in the setting of HIV-HBV co-infection.
Evolutionary Events Shaping The Genome Of Cryptococcus Neoformans And Their Effects On Pathogenesis
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
Recurring infection in patients with fungal meningitis caused by Cryptococcus neoformans is typically caused by persistence of the original infection rather than reinfection with a new strain. Our analysis of relapse strains shows that small-scale alterations frequently occur at the chromosome ends - regions containing important pathogenesis-related genes in other pathogens. We seek to characterise this microevolution further to understand how it contributes to the success of this pathogen.
The diversity of HIV quasispecies within a single AIDS patient is far greater than the global diversity of influeneza annually, highlighting the enormous burden HIV imposes on the immune network. The capacity of HIV-1 to evolve quickly has significantly impaired our effort to produce effective vaccine and long lasting treatment strategy. This project utilizes multidisciplinary approaches to delineate determinants that drives the diversification of HIV-1.
Elucidation Of Immune Mechanisms Underlying HSV Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$573,993.00
Summary
HSV-1 and -2 causes genital herpes, cold sores, encephalitis, potential fatal neonatal herpes, keratitis and blindness as well as severe disease in transplant patients. HSV infection also enhances the acquisition of HIV by 2-3 fold. Investigating the mechanism of immune response to HSV infection or components of HSV will assist in understanding immune control of HSV, HSV vaccine development, and assist in reducing in HIV spread.
Abalone Council Australia Ltd Management Of The National Wild Catch Abalone Research, Development And Extension Program (2024 To 2029)
Funder
Fisheries Research and Development Corporation
Funding Amount
$760,000.00
Summary
Implementing an Industry Partnership Agreement (IPA) was necessary to provide a more coordinated approach to RD&E and ensure that research funds were utilised in the more cost effective and strategic manner. It also “quarantined” funds to be overseen by the ACA for investment in Abalone specific research, giving the industry greater opportunity for input into the research that was funded and greater relevance of project outputs.
The second ACA/FRDC IPA expired in early 2024 and the AC ....Implementing an Industry Partnership Agreement (IPA) was necessary to provide a more coordinated approach to RD&E and ensure that research funds were utilised in the more cost effective and strategic manner. It also “quarantined” funds to be overseen by the ACA for investment in Abalone specific research, giving the industry greater opportunity for input into the research that was funded and greater relevance of project outputs.
The second ACA/FRDC IPA expired in early 2024 and the ACA Board and FRDC are now establishing a new IPA for the period 2024 to 2029.
Historically, industry’s focus has been on management and stock sustainability, although the potential for growth through higher harvest levels via upward quota adjustment is limited. Indeed, since 2011/12, the total annual harvest has fallen from 4,450t to 1965 t in 2023/2024 (a reduction of 56%). The decreasing productivity of Australian abalone fisheries may be attributed to a number of “complex” causes of which fishing mortality is but one; others include: habitat loss due to Centrostephanus urchin, environmental change & marine heat waves, disease outbreak (AVG, Perkinsus), and reduced natural recruitment, all of which reduce fishery productivity.
Please refer to the below table which clearly shows the decreasing productivity of all abalone fisheries in Australia.
State TACC in tonnes 2011/2012 TACC in tonnes 2017/2018 TACC in tonnes 2022/2023 TACC in tonnes 2023/2024 Tasmania 2366 1333.5 794.5 756 South Australia 834 717.5 564.4 544 Victoria 806 595.3 610.9 457 Western Australia 349 143.4 123.5 108 New South Wales 94 100 100 100 TOTAL 4450 2889.70 2193.3 1965
Notwithstanding the lower harvest levels, the industry remains a significant exporter with a total GVP around $135 million in 2023/24.
Objectives: 1. To coordinate the planning, implementation, and reporting of abalone related R&D projects funded by the FRDC to achieve the outcomes specified in the third ACA Strategic Plan. Specifically, this must be at both the National level and regionally across WA, SA, VIC, NSW and TAS. 2. To facilitate the abalone industry participation in FRDC projects and the extension and utilization of the project results. 3. To deliver resources and processes that consolidates and coordinates Abalone related RD&E planning and funding so that overall RD&E outcomes are delivered in an efficient and cost-effective manner. Read moreRead less
SCRC: The SIPP Program - Connecting Early Career Researchers With The Australian Seafood Industry Through Meaningful Coaching Partnerships: Year 2
Funder
Fisheries Research and Development Corporation
Summary
Disconnection between research and commercial sectors are a real challenge for the seafood industry as a whole. This disconnection leads to lack of communication about research needs from industry and poor adoption of research outcomes. Consultation with industry has identified a need for more industry ready graduates who have a deeper understanding and connection with the Australian seafood industry and understand more thoroughly the nature and the challenges commercial facilities face in all f ....Disconnection between research and commercial sectors are a real challenge for the seafood industry as a whole. This disconnection leads to lack of communication about research needs from industry and poor adoption of research outcomes. Consultation with industry has identified a need for more industry ready graduates who have a deeper understanding and connection with the Australian seafood industry and understand more thoroughly the nature and the challenges commercial facilities face in all facets of their business.
In addition, there is a need to enhance two way communication and cooperation between industry and research providers. The CRC SIPP program will assist in improving that process by enabling opportunities for industry and researchers to understand each other’s views, challenges and promote better communication on ideas and projects.Read moreRead less
Review the preconditions and the underpinning industry and government structures necessary for the successful implementation of co management Objectives: 1. To investigate the resilience of the various co-management approaches to a changing fishing operational environment (biophysical and socio-governance) 2. To look at the lessons learnt, and the challenges arising from, the implementation of co-management in all jurisdictions; with a view to identifying positive and negati ....Review the preconditions and the underpinning industry and government structures necessary for the successful implementation of co management Objectives: 1. To investigate the resilience of the various co-management approaches to a changing fishing operational environment (biophysical and socio-governance) 2. To look at the lessons learnt, and the challenges arising from, the implementation of co-management in all jurisdictions; with a view to identifying positive and negative drivers 3. To assess the skill sets needed to successfully implement co-management 4. To assess how to resource co-management once the fishery has moved past the RD&E phase 5. To identify the relevant RD&E questions to inform future investment 6. To document recommendations for the future implementation of co management Read moreRead less