Long-term Implications And Outcomes Of Anti Hepatitis B Virus (HBV) Treatment In HIV-HBV Co-infection
Funder
National Health and Medical Research Council
Funding Amount
$293,931.00
Summary
Chronic hepatitis B (HBV) infection may cause serious liver disease in some people, including liver failure or liver cancer. Being infected with both HBV and HIV increases the chances of these complications occurring and the rate they develop. The optimal long term management of HIV-HBV co-infection remains unclear; and the effects of antiretroviral therapy on liver disease progression outcome is unknown in the setting of HIV-HBV co-infection.
Evolutionary Events Shaping The Genome Of Cryptococcus Neoformans And Their Effects On Pathogenesis
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
Recurring infection in patients with fungal meningitis caused by Cryptococcus neoformans is typically caused by persistence of the original infection rather than reinfection with a new strain. Our analysis of relapse strains shows that small-scale alterations frequently occur at the chromosome ends - regions containing important pathogenesis-related genes in other pathogens. We seek to characterise this microevolution further to understand how it contributes to the success of this pathogen.
The diversity of HIV quasispecies within a single AIDS patient is far greater than the global diversity of influeneza annually, highlighting the enormous burden HIV imposes on the immune network. The capacity of HIV-1 to evolve quickly has significantly impaired our effort to produce effective vaccine and long lasting treatment strategy. This project utilizes multidisciplinary approaches to delineate determinants that drives the diversification of HIV-1.
Elucidation Of Immune Mechanisms Underlying HSV Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$573,993.00
Summary
HSV-1 and -2 causes genital herpes, cold sores, encephalitis, potential fatal neonatal herpes, keratitis and blindness as well as severe disease in transplant patients. HSV infection also enhances the acquisition of HIV by 2-3 fold. Investigating the mechanism of immune response to HSV infection or components of HSV will assist in understanding immune control of HSV, HSV vaccine development, and assist in reducing in HIV spread.
SCRC: The SIPP Program - Connecting Early Career Researchers With The Australian Seafood Industry Through Meaningful Coaching Partnerships: Year 2
Funder
Fisheries Research and Development Corporation
Summary
Disconnection between research and commercial sectors are a real challenge for the seafood industry as a whole. This disconnection leads to lack of communication about research needs from industry and poor adoption of research outcomes. Consultation with industry has identified a need for more industry ready graduates who have a deeper understanding and connection with the Australian seafood industry and understand more thoroughly the nature and the challenges commercial facilities face in all f ....Disconnection between research and commercial sectors are a real challenge for the seafood industry as a whole. This disconnection leads to lack of communication about research needs from industry and poor adoption of research outcomes. Consultation with industry has identified a need for more industry ready graduates who have a deeper understanding and connection with the Australian seafood industry and understand more thoroughly the nature and the challenges commercial facilities face in all facets of their business.
In addition, there is a need to enhance two way communication and cooperation between industry and research providers. The CRC SIPP program will assist in improving that process by enabling opportunities for industry and researchers to understand each other’s views, challenges and promote better communication on ideas and projects.Read moreRead less
Review the preconditions and the underpinning industry and government structures necessary for the successful implementation of co management Objectives: 1. To investigate the resilience of the various co-management approaches to a changing fishing operational environment (biophysical and socio-governance) 2. To look at the lessons learnt, and the challenges arising from, the implementation of co-management in all jurisdictions; with a view to identifying positive and negati ....Review the preconditions and the underpinning industry and government structures necessary for the successful implementation of co management Objectives: 1. To investigate the resilience of the various co-management approaches to a changing fishing operational environment (biophysical and socio-governance) 2. To look at the lessons learnt, and the challenges arising from, the implementation of co-management in all jurisdictions; with a view to identifying positive and negative drivers 3. To assess the skill sets needed to successfully implement co-management 4. To assess how to resource co-management once the fishery has moved past the RD&E phase 5. To identify the relevant RD&E questions to inform future investment 6. To document recommendations for the future implementation of co management Read moreRead less
Aquatic Animal Health Subprogram: Technical Guidelines For The Translocation Of Live Aquatic Animals
Funder
Fisheries Research and Development Corporation
Funding Amount
$18,000.00
Summary
There is an existing National Policy for the Translocation of Live Aquatic Organisms. published by the Ministerial Council of Forestry, Fisheries and Aquaculture (1999). This provides the policy basis for translocation within Australia. Industry concern about the practical processes for achieving translocation approval lead to the funding of FRDC 2002/080. In addition, recent concern among jurisdictions over VER outbreaks has emphasised the need to develop technical guidelines to underpin test ....There is an existing National Policy for the Translocation of Live Aquatic Organisms. published by the Ministerial Council of Forestry, Fisheries and Aquaculture (1999). This provides the policy basis for translocation within Australia. Industry concern about the practical processes for achieving translocation approval lead to the funding of FRDC 2002/080. In addition, recent concern among jurisdictions over VER outbreaks has emphasised the need to develop technical guidelines to underpin testing, as well as policy guidelines, for finfish. Objectives: 1. To progress a common approach to the translocation of live finfish across Australia for aquaculture and restocking purposes. Read moreRead less