Understanding Pathogen Effects On Human T Cell Receptor Diversity And Function
Funder
National Health and Medical Research Council
Funding Amount
$808,693.00
Summary
HIV diversity observed at the global level is mostly due to the selection pressure exerted on the virus by our adaptive immune response. This process is important in determining infection outcome. This proposal will use a unique single cell approach to understand this complex host-viral interaction to identify important correlates of immune efficacy against HIV that will aid in the rational design of potential vaccine candidates and addresses a fundamental concept in anti-viral immunity.
The Influence Of HIV On T Cell Function And Application To Vaccine Design.
Funder
National Health and Medical Research Council
Funding Amount
$427,899.00
Summary
Development of a safe, effective vaccine remains the only viable means of abating the human immunodeficiency virus (HIV) pandemic in the long term. Scientists must develop a vaccine that could protect against many diverse HIV strains worldwide. This research aims to understand the ways in which HIV mutates to avoid human immune responses in order to determine how best to design a vaccine. The findings could be applied to other infectious diseases for which vaccines are also needed.