Development Of An Assay To Distinguish Between Recent And Established HIV-1 Infection
Funder
National Health and Medical Research Council
Funding Amount
$192,500.00
Summary
We have discovered a marker of recent HIV infection. Further refinement of this assay and fully evaluating it on samples from individuals infected with different subtypes of the virus will result in an HIV incidence assay ready for commercialisation. An assay capable of distinguishing between recently acquired and established HIV infection would be most valuable in establishing the incidence of infection for epidemiological surveys, to clearly identify new infections following vaccine trials and ....We have discovered a marker of recent HIV infection. Further refinement of this assay and fully evaluating it on samples from individuals infected with different subtypes of the virus will result in an HIV incidence assay ready for commercialisation. An assay capable of distinguishing between recently acquired and established HIV infection would be most valuable in establishing the incidence of infection for epidemiological surveys, to clearly identify new infections following vaccine trials and identify HIV infection as opposed to transfer of maternal antibodies in new born infants.Read moreRead less
Sytemic And Mucosal Functional Antibodies In Protection Against HIV
Funder
National Health and Medical Research Council
Funding Amount
$559,501.00
Summary
Only one human HIV vaccine has shown any level of protective efficacy. However the mechanisms behind how this vaccine was protective are still not fully understood. Additionally, HIV is primarily transmitted through mucosal sites, however very little is know about vaccine immune responses at these sites. Thus this proposal aims to further define the mechanisms of antibody protection against HIV at both systemic and mucosal locations, in order to guide future HIV vaccine design efforts.
Importance Of Functional Antibodies Against Infectious Diseases
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Antibodies are highly functional proteins capable of recognizing infectious disease pathogens and instructing surrounding immune cells to attack them. This project aims to identify specific antibody targets on HIV and Mycobacterium Tuberculosis associated with protection/control of disease and to understand the mechanisms behind the most functional antibodies. Ultimately, these studies will guide the development of future vaccines and therapies against these deadly pathogens.
Innate Immune Effector Recruiting Potential Of HIV-1 Human Vaccine Induced Antibodies
Funder
National Health and Medical Research Council
Funding Amount
$333,018.00
Summary
A HIV vaccine is urgently needed. A recent human HIV vaccine trial has indicated that Antibody Dependent Cellular Cyotoxicity (ADCC) may be protective. Understanding the role of ADCC HIV-specific antibodies in the context of vaccination has now become one of the most critical questions in HIV vaccine research today. This research aims to comprehensively study ADCC in samples from various HIV Vaccine trials to develop improved vaccine strategies to prevent the devastating consequences of HIV/AIDS ....A HIV vaccine is urgently needed. A recent human HIV vaccine trial has indicated that Antibody Dependent Cellular Cyotoxicity (ADCC) may be protective. Understanding the role of ADCC HIV-specific antibodies in the context of vaccination has now become one of the most critical questions in HIV vaccine research today. This research aims to comprehensively study ADCC in samples from various HIV Vaccine trials to develop improved vaccine strategies to prevent the devastating consequences of HIV/AIDS.Read moreRead less