Falls and broken bones are costly health problems among the elderly, even more so when there is a growing older population aged over 65 years. In Australia about 1 million older people have at least one fall each year and about 40-60% will sustain major injuries including broken bones. Therefore there is a need to identify effective ways to reduce falls and improve outcomes of those who break a bone, especially of the hip.
Otago Exercise Program For Older Adults Recovering From PFF: Feasibility, Gait Analysis And Physical Function.
Funder
National Health and Medical Research Council
Funding Amount
$88,214.00
Summary
Hip fractures are a common, serious and rapidly growing problem for older people. The consequences for an individual can be devastating including reduced mobility, loss of independence and ultimately admission to a nursing home. This study aims to identify strategies to assist clinicians in the individual prescription of the most appropriate therapy, improve rehabilitation programs and ultimately the outcomes for hip fracture sufferers.
Bone Fragility: The Neglected Role Of Cortical Porosity
Funder
National Health and Medical Research Council
Funding Amount
$620,381.00
Summary
Cortical (outer shell) or compact bone constitutes 80% of the skeleton. It is not solid as implied by its name but made of inter-connected canals resembling a network of roads. We recently discovered that most of the bone loss with age occurs from these canals, not from t rabecular bone as currently believed. This suggests to know why and how bone breaks requires the study of the morphology of these canals and how they change with age. This is what we propose to do. It has never been done.
Fragility Fractures: The Neglected Role Of Cortical Porosity
Funder
National Health and Medical Research Council
Funding Amount
$865,474.00
Summary
We just discovered that bone lost with age occurs mostly from pores within the cortex (outer shell) of the bone; These pores become larger (porosity) making bones fragile. This process is poorly detected by bone density (currently used tool) so that most people with weak bones are missed. To address this issue, we have for the first time, develop a technology to accurately quantify porosity in living peoples. With teams around the world, we aim here to fill this gap in the diagnosis.
Whole Body Vibration For Osteoporosis: Shaking Up Our Treatment Options
Funder
National Health and Medical Research Council
Funding Amount
$961,017.00
Summary
Our aim is to examine the ability of vibration alone and in combination with osteoporosis drugs to reduce hip fracture in postmenopausal women. In Australia, 1 in 2 women >60yrs, will sustain an osteoporotic fracture. Only drugs notably decrease fracture; however none are entirely effective and some patients don’t respond. Whole body vibration has emerged as a potentially effective therapy. A combination of vibration and drugs may enhance the effects of both and revolutionise treatment.
Genetic Regulation Of Hip Geometry, Structure And Fracture
Funder
National Health and Medical Research Council
Funding Amount
$403,625.00
Summary
Osteoporotic hip fracture is common in the elderly and a major cause of hospitalization. Hip fracture may lead to surgery, chronic reduced mobility, loss of function, institutionalization or death. The term osteoporosis covers a heterogeneous syndrome including juvenile, secondary (e.g. corticosteroid induced) and postmenopausal osteoporosis. This later broad grouping shows evidence of a strong familial association. Previous work has shown that a family history of fracture increases the risk of ....Osteoporotic hip fracture is common in the elderly and a major cause of hospitalization. Hip fracture may lead to surgery, chronic reduced mobility, loss of function, institutionalization or death. The term osteoporosis covers a heterogeneous syndrome including juvenile, secondary (e.g. corticosteroid induced) and postmenopausal osteoporosis. This later broad grouping shows evidence of a strong familial association. Previous work has shown that a family history of fracture increases the risk of fracture by more than four fold. Furthermore, studies in twins have persistently shown that phenotypes such as bone mineral density (BMD), broadband ultrasound attenuation of bone and hip structural indices are strongly inherited. This confirms a genetic basis for the disease in some individuals. Community health in general has improved substantially in Australia in the past four decades and this has resulted in increased longevity. In contrast, the incidence of hip fracture and the resulting drain on public health funding continues to increase rapidly. Presently the cost of osteoporosis in Australia is $7.5 billion per annum. Hip fracture accounts for the majority of these costs. Instituting effective prevention strategies is essential. This project aims to contribute to one of Australia's National Research Pritoities by improving understanding about the way in which inherited aspects of hip geometry and structure contribute to the hip fracture susceptibility. We have successfully completed genome screen projects studying genetic linkage in the families to localize genes regulating BMD in the past. However, BMD is only one of a number of relevant phenotypes. In relation to hip fracture, geometry and structure are thought to be particularly important. In this project we will make use of existing resources to advance studies of both genetic linkage and association to examine fundamental issues related to hip facture.Read moreRead less
Is Hip Fracture Rehabilitation Cost Effective In Residential Care? A Randomised Controlled Trial Of Rehabilitation
Funder
National Health and Medical Research Council
Funding Amount
$137,970.00
Summary
Some of the frailest members of our community live in nursing homes and a hip fracture can be devastating to a person with dementia as it can leave them permanently unable to walk. We don't know how best to promote recovery when they break their hips. At present there is an assumption that rehabilitation at this stage of life is not worthwhile but this study will test whether the benefits outweigh the costs. We will test whether an assessment by a geriatrician and rehabilitation improves walking ....Some of the frailest members of our community live in nursing homes and a hip fracture can be devastating to a person with dementia as it can leave them permanently unable to walk. We don't know how best to promote recovery when they break their hips. At present there is an assumption that rehabilitation at this stage of life is not worthwhile but this study will test whether the benefits outweigh the costs. We will test whether an assessment by a geriatrician and rehabilitation improves walking, independence and quality of life.Read moreRead less