The Role Of Mucosal-associated Invariant T (MAIT) Cells And Gut Micro-biota In The Pathogenesis Of Paediatric Autoimmune Liver Disease (AILD).
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
Liver disease can develop when a faulty immune system attacks the liver, occasionally leading to significant liver scarring and liver transplantation. Children who develop this condition need life-long treatment, but not every child responds. I intend to study immune cells and their activity in the blood and liver of affected children. By identifying the role of the immune system in liver inflammation, we hope to find out why children develop this disease and how best to treat them.
Microparticles As Novel Biomarkers In Liver Cancer
Funder
National Health and Medical Research Council
Funding Amount
$85,833.00
Summary
No current highly sensitive or specific diagnostic and prognostic biomarker for hepatocellular carcinoma (HCC) exists. We will identify novel nucleic acid signatures in the circulation of patients with HCC through Next Generation Sequencing. Plasma microvesicles will be isolated and their contents analyzed to identify novel genetic biomarkers and fusion gene constructs specific for HCC. Resultant panel of novel biomarkers for HCC will be validated on the Australian STREP cohort of HCC patients.
Implementing And Enhancing Evidence-based Research And Practice In Hepatology
Funder
National Health and Medical Research Council
Funding Amount
$569,219.00
Summary
The overall aim of this proposal is to tackle unmet challenges in liver disease research. This will be achieved through (a) Population level programs to deliver new treatments for patients with hepatitis C; (b) Developing integrated care models to treat hepatitis B; (c) Developing population-level programs for liver cancer control; and (d) Identification of patients at risk of severe liver disease through understanding the genetic basis of disease progression.
Manganese is an essential trace element for normal health. However in some medical conditions manganese can build up in the brain and cause a Parkinson's like disease called manganism. Experimental evidence suggests that the liver plays an important role in the development of manganism and this project aims to explore the way the liver handles manganese in health and disease. These studies may assist in understanding how manganism develops.
The Effect Of IL28B Haplotype On Hepatitis C Virus Infection And Treatment Response
Funder
National Health and Medical Research Council
Funding Amount
$525,576.00
Summary
About 3% of the world population is currently infected with hepatitis C virus (HCV). Most have chronic infection with a high risk for progressive liver fibrosis and subsequent liver cirrhosis and hepatocellular carcinoma. We have recently demonstrated genetic variants of the IL28B gene predict viral clearance with and without treatment after HCV infection. Determining why will impact on the development of new therapies, optimise use of current therapies, and identify patients who may respond to ....About 3% of the world population is currently infected with hepatitis C virus (HCV). Most have chronic infection with a high risk for progressive liver fibrosis and subsequent liver cirrhosis and hepatocellular carcinoma. We have recently demonstrated genetic variants of the IL28B gene predict viral clearance with and without treatment after HCV infection. Determining why will impact on the development of new therapies, optimise use of current therapies, and identify patients who may respond to alternative therapies.Read moreRead less
Understanding the vesicle release mechanisms that regulate peripheral serotonin levels. The purpose of this project is to understand how serotonin is released into the circulation from specialised cells within the gut. As circulating serotonin controls multiple biological systems within the gut and throughout the body, the outcomes of this project will further understandings of the systems controlling essential bodily functions.
Improving Therapeutic Outcomes Through Pharmaceutical Sciences Research
Funder
National Health and Medical Research Council
Funding Amount
$823,008.00
Summary
This Fellowship seeks to improve patient outcomes by better understanding of how drugs and nanotechnology systems interact with the body under normal and diseased conditions, and to translate these findings into improved therapeutic and chemical safety practice. Aspects include how medicines are absorbed through skin; are handled in normal and diseased patients; are best administered, including to intensive care patients; and the development of new clinical pharmacy practitioner - researchers.