The Role Of Mitochondrial DNA In Age-related Hearing Loss
Funder
National Health and Medical Research Council
Funding Amount
$260,475.00
Summary
Hearing loss is an extremely common and under-studied age-related disability, affecting 39% of Australians aged 50 years or older. Both genetic and environmental factors may contribute to the development of age-related hearing loss. Human genetic material (DNA) resides in two places in body cells; the nucleus and in organelles called mitochondria. This is due to the fact that mitochondria were derived from bacteria that were engulfed by the cell back in primordial life. Although this genetic mat ....Hearing loss is an extremely common and under-studied age-related disability, affecting 39% of Australians aged 50 years or older. Both genetic and environmental factors may contribute to the development of age-related hearing loss. Human genetic material (DNA) resides in two places in body cells; the nucleus and in organelles called mitochondria. This is due to the fact that mitochondria were derived from bacteria that were engulfed by the cell back in primordial life. Although this genetic material is different to nuclear DNA, it has an essential role in helping to provide energy for the cell. Genetic mutations in the DNA residing in the mitochondria have been associated with a number of conditions, usually affecting tissues that require large amounts of energy, such as the brain, muscle, heart, retina and the cochlea of the ear. The commonest clinical manifestation of mitochondrial disease is thought to be hearing loss. This project investigates the role that abnormal mitochondrial DNA plays in the development of hearing impairment by studying subjects from a representative Australian community who participated in a large population study of hearing loss. We will assess whether different sectors of mitochondrial DNA predispose particular individuals to the development of hearing loss or accelerate its onset. The Blue Mountains Hearing Study is able to take into account other factors known to be associated with hearing loss (industrial noise exposure, diabetes, smoking).Read moreRead less
Improving Music Appreciation For People With Prosthetic Hearing Devices By Enhancing Auditory Stream Segregation
Funder
National Health and Medical Research Council
Funding Amount
$266,560.00
Summary
Music perception is one of the most often-cited problems for people with hearing aids or cochlear implants. Part of the problem is related to the reduced ability to hear different instruments or melodic lines separately. This ability is based on perceptual differences between auditory streams. Psychophysics experiments will be performed to understand the effect of different acoustic parameters on auditory streaming. An innovative approach to restore music appreciation will be tested on people wi ....Music perception is one of the most often-cited problems for people with hearing aids or cochlear implants. Part of the problem is related to the reduced ability to hear different instruments or melodic lines separately. This ability is based on perceptual differences between auditory streams. Psychophysics experiments will be performed to understand the effect of different acoustic parameters on auditory streaming. An innovative approach to restore music appreciation will be tested on people with impaired hearing.Read moreRead less
Early Indicators Of Noise Injury: Are Decreased Auditory Processing Skills Evident In Noise-exposed Adults Prior To Diagnosis Of Hearing Loss?
Funder
National Health and Medical Research Council
Funding Amount
$367,605.00
Summary
Recent research indicates that noise-exposed individuals with similar hearing thresholds to non-noise exposed counterparts are more likely to have diminished temporal and spectral auditory processing abilities. This research aims to determine the relationship between noise exposure levels and auditory processing difficulties; the influence of musical training in ameliorating these difficulties; and a neurological model of causation, operation and possible remediation of these difficulties.
Cochlear Type II Neurons In Contralateral Suppression
Funder
National Health and Medical Research Council
Funding Amount
$459,434.00
Summary
Sound in one ear affects hearing in the other ear. This contralateral suppression is important for hearing attention and protection from noise damage. We will test the hypothesis that cochlear type II sensory neurons provide the sensory input for this process using models where neuronal development is altered, or the neurons are removed. The study addresses hearing disability in society, facilitating cochlear prosthesis development and the understanding of hearing loss.
Hearing Protection Conferred By P2X2 Receptor Signaling In The Cochlea
Funder
National Health and Medical Research Council
Funding Amount
$580,019.00
Summary
Hearing loss from noise damage and ageing is the principal sensory disability in our society. This project will determine the contribution of the P2X2 receptor to protection from noise-induced hearing loss. We have found that P2X2 knockout mice have minimal temporary threshold shift. We will investigate the physiological basis for this and determine why this mouse model has greater hearing loss with intense sound and faster age-related hearing loss compared with wildtype controls.
Improving Treatment And Outcomes Of Congenital Hearing Loss At The Population Level
Funder
National Health and Medical Research Council
Funding Amount
$265,138.00
Summary
Around 600 Australian babies are born with congenital hearing loss each year. Despite great advances in early diagnosis and treatment, affected children have language and other skills well below what they can potentially achieve. My research will a) examine trends in congenital hearing loss outcomes, b) enrich existing data with novel genetic and clinical data, to enable early prediction of future outcomes to direct management, and c) discover ways to prevent hearing loss progression.
Evaluating Perceptual Benefits Of Bilateral Cochlear Implants For Young Children And Infants
Funder
National Health and Medical Research Council
Funding Amount
$452,843.00
Summary
The cochlear implant (bionic ear) has revolutionised communication for children with profound hearing loss. Nevertheless, children with the standard single implant still face huge challenges in educational and social settings. Difficulties include understanding speech that is soft, or speech in noisy environments, such as the classroom. Also, with one implant, children cannot locate the source of sound, such as the speaker in a group conversation, team-mates during sport, or an oncoming car. Res ....The cochlear implant (bionic ear) has revolutionised communication for children with profound hearing loss. Nevertheless, children with the standard single implant still face huge challenges in educational and social settings. Difficulties include understanding speech that is soft, or speech in noisy environments, such as the classroom. Also, with one implant, children cannot locate the source of sound, such as the speaker in a group conversation, team-mates during sport, or an oncoming car. Research with other normal hearing and hearing impaired groups suggests that two (bilateral) implants may possibly improve performance in these conditions. Although hundreds of children worldwide have received bilateral implants, very limited evidence is available to indicate whether two implants are significantly better than one, especially for young children. The main aim of the research is to evaluate the improvement in listening performance when young children and infants use two implants as compared with one. An additional aim is to gain clinical knowledge of bilateral implant use in order to develop selection criteria and management protocols for young bilateral candidates in the future. Results of this research will determine if bilateral implants should become a standard option for young children at the RVEEH-University of Melbourne Implant Clinic. The results will be published and presented internationally to influence clinical practice worldwide. All children using a cochlear implant, or in need of one in the future, will benefit as the study outcomes will indicate the best choice of hearing devices for individual children, and help to determine best-practice management if bilateral implants become an option for all children.Read moreRead less