Developing methods for benefit measurement in health-related economic analyses and their use in selecting public health promotional programs. The program involves the creation, validation and use of a suite of instruments for evaluating outcomes of health promotional programs, including adult and childhood obesity, depression and smoking - areas that are universally recognised as being of importance for the Australian community. The program will provide multiple scoring algorithms for each of th ....Developing methods for benefit measurement in health-related economic analyses and their use in selecting public health promotional programs. The program involves the creation, validation and use of a suite of instruments for evaluating outcomes of health promotional programs, including adult and childhood obesity, depression and smoking - areas that are universally recognised as being of importance for the Australian community. The program will provide multiple scoring algorithms for each of the instruments in order to test the sensitivity of results to assumptions made about social values, and will produce Australian estimates of the person trade-off weights used in the Australian and Victorian Burden of Disease studies (which presently use Dutch PTO weights). Read moreRead less
Identifying And Implementing Standardised Outcomes In Kidney Transplantation
Funder
National Health and Medical Research Council
Funding Amount
$274,076.00
Summary
The inconsistencies and lack of patient involvement in outcome selection for research can undermine shared decision-making and patient-centred care. Over three years, this global project will bring together patients,family members, healthcare providers, policy makers and industry to identify core outcomes in kidney transplantation. Implementation of the core outcome set will ensure that outcomes report in research are relevant, meaningful and important to patients with a kidney transplant.
Developing And Validating Indicators Of Quality Nursing Care In A Paediatric Setting
Funder
National Health and Medical Research Council
Funding Amount
$92,067.00
Summary
Nursing sensitive outcomes are measures of the quality of care provided by nurses. This study will establish those measures within Australian children’s hospitals. This information can be used to better understand and improve nurses’ practice. It will provide a standardised approach to measuring outcomes of paediatric nursing care and will provide reliable and valid information for benchmarking with similar children’s hospitals which in turn will assist in promoting patient safety.
Improving The Health And Development Of High Risk Preterm Newborns
Funder
National Health and Medical Research Council
Funding Amount
$338,381.00
Summary
Preterm children have more health and developmental problems than those born full term. Although we know the problems faced by those tiniest and most immature, more questions remain. What problems do they face as adults? What new treatments are available to improve their outcomes? Are the more “mature” preterms at risk as well? My research program aims to address these questions through the efforts of the Victorian Infant Collaborative Study team, a large research team that I lead.
Diagnostics For Mixture Regression Models: Applications To Public Health
Funder
National Health and Medical Research Council
Funding Amount
$128,250.00
Summary
In many public health studies, finite mixture regression models are often used to analyse data arising from heterogeneous populations. It is important to assess the stability of parameter estimates and the validity of statistical inferences when the underlying assumptions appear to be violated, but appropriate diagnostics are lacking in the literature. This research aims to develop effective diagnostic methods for assessing the adequacy of mixture regression models and the sensitivity of accompa ....In many public health studies, finite mixture regression models are often used to analyse data arising from heterogeneous populations. It is important to assess the stability of parameter estimates and the validity of statistical inferences when the underlying assumptions appear to be violated, but appropriate diagnostics are lacking in the literature. This research aims to develop effective diagnostic methods for assessing the adequacy of mixture regression models and the sensitivity of accompanying test statistics. The methodology developed will enable health care professionals to focus on substantive issues and to draw accurate and valid conclusions inferred from correlated and over-dispersed outcomes. In the presence of anomalous observations, the influence diagnostics can provide insights into the source of heterogeneity and the apparent over-dispersion, while accommodating the inherent correlation due to the longitudinal study design or nested data structure. Significance of the research lies in its scientific novelty and the breadth of its practical applications. The benefits to public health will accrue both nationally and internationally. For the empirical studies that motivated and are linked to this research, evaluation of health outcomes has significant implications in the prevention and control of recurrent urinary tract infections, hospital strategic planning, and post-stroke care and rehabilitation management. Moreover, appropriate assessment of a physical activity intervention for older adults is pertinent to falls prevention and reduction of musculoskeletal disorders among sedentary seniors.Read moreRead less
Hierarchical Finite Mixture Modelling Of Health Outcomes: A Risk-adjusted Random Effects Approach
Funder
National Health and Medical Research Council
Funding Amount
$117,000.00
Summary
In medical and health studies, finite mixture regression models have been used to analyze data arising from heterogeneous populations. Traditionally, the application of mixture models is mainly concerned with finite normal mixtures. Recent computational advances and methodological developments have enhanced the extension of the method to non-normal finite mixtures, such as the modelling of discrete responses in finite mixture of generalized linear models and overlapping phases of failure time da ....In medical and health studies, finite mixture regression models have been used to analyze data arising from heterogeneous populations. Traditionally, the application of mixture models is mainly concerned with finite normal mixtures. Recent computational advances and methodological developments have enhanced the extension of the method to non-normal finite mixtures, such as the modelling of discrete responses in finite mixture of generalized linear models and overlapping phases of failure time data in the context of survival analysis. However, due to the hierarchical study design or the data collection procedure, the inherent correlation structure and-or clustering effects present may contribute to extra variations and violation of the independence assumption, resulting in spurious associations and misleading inferences based on the finite mixture model. This project aims to present a unified approach to accommodate both heterogeneity and dependency of observations, by incorporating random effects into finite mixture regression models. The new methodology will provide an integrated framework to analyze heterogeneous and correlated health outcomes. Three empirical studies are considered, namely, evaluation of an occupational injury reduction intervention, length of hospital stay modeling, and analysis of survival times of patients after cardiac surgery. The long term benefits to bioscience are accurate and valid conclusions inferred from medical and health studies, as well as the correct identification of high-risk subgroups. For the three application areas of this project, the improved analyses will specifically enable the evaluation of a participatory ergonomics intervention, the assessment of hospital efficiency and factors influencing length of hospitalization, and the determination of effectiveness of treatments prescribed pre- and post- operation, respectively.Read moreRead less
Ear Health, Hearing, Speech And Language Development In Urban Aboriginal Children
Funder
National Health and Medical Research Council
Funding Amount
$445,617.00
Summary
Studies from the Northern Territory and Western Australia have established that Aboriginal children experience earlier, more frequent and more severe middle ear disease than any other children worldwide. There is little information on Aboriginal communities in urban setings or those living in NSW. This study will fill this knowledge gap by examining the burden of middle ear disease, hearing impairment and consequent speech and language delays in urban Aboriginal children in NSW.
Implications Of The Increasing Duration Of Life Spent With Obesity For Population Health
Funder
National Health and Medical Research Council
Funding Amount
$251,830.00
Summary
As the prevalence of obesity at younger ages increases, people are living longer with obesity. We have recently shown that this has an increased risk of mortality and diabetes. In this project we will look at the extent to which an increasing length of time lived with obesity is also associated with increased risks of hypertension, heart disease, cancer, arthritis and disability. We will also look at the effect of this increasing duration on the overall health of Australian adults.