Identifying And Implementing Standardised Outcomes In Kidney Transplantation
Funder
National Health and Medical Research Council
Funding Amount
$274,076.00
Summary
The inconsistencies and lack of patient involvement in outcome selection for research can undermine shared decision-making and patient-centred care. Over three years, this global project will bring together patients,family members, healthcare providers, policy makers and industry to identify core outcomes in kidney transplantation. Implementation of the core outcome set will ensure that outcomes report in research are relevant, meaningful and important to patients with a kidney transplant.
Implications Of The Increasing Duration Of Life Spent With Obesity For Population Health
Funder
National Health and Medical Research Council
Funding Amount
$251,830.00
Summary
As the prevalence of obesity at younger ages increases, people are living longer with obesity. We have recently shown that this has an increased risk of mortality and diabetes. In this project we will look at the extent to which an increasing length of time lived with obesity is also associated with increased risks of hypertension, heart disease, cancer, arthritis and disability. We will also look at the effect of this increasing duration on the overall health of Australian adults.
COst-effectiveness analyses of improved adherence to Management PLans among AustralIANS (COMPLIANS). Chronic diseases are the leading cause of disability in the community and over $34billion is spent each year on health services in Australia treating these diseases. It is hoped that the project will lead to identification of opportunities for cost-effective prevention and treatment of lung and other chronic diseases and that this will lead to more cost-effective deployment of healthcare resourc ....COst-effectiveness analyses of improved adherence to Management PLans among AustralIANS (COMPLIANS). Chronic diseases are the leading cause of disability in the community and over $34billion is spent each year on health services in Australia treating these diseases. It is hoped that the project will lead to identification of opportunities for cost-effective prevention and treatment of lung and other chronic diseases and that this will lead to more cost-effective deployment of healthcare resources. Improvements in the management and treatment of these diseases will result in an improvement in the quality of life of Australian patients, and their active and productive participation in society for as long as possible.Read moreRead less
Investigating The Relationships Between Cannabis And Other Drug Use, Mental Health, Early-life Factors And Life-course Outcomes: Integrative Analyses Of Data From Four Australasian Cohort Studies
Funder
National Health and Medical Research Council
Funding Amount
$292,097.00
Summary
The current study will be the first of its kind to use integrative data analyses _ a highly innovative approach _ to pool data from four large and long-running Australasian cohort studies to better understand the link between cannabis use and later-life outcomes. Dramatically improved knowledge of these relationships will create a clearer picture of the interventions required to reduce the harms associated with cannabis use.
Post-implementation economic evaluation of childhood vaccination programs. This project will develop a novel framework for assessing the value for money achieved by childhood vaccination programs. This will provide decision makers with methodologically sound economic assessments that incorporate real world program outcomes.
Exploiting SNP Data In Epidemiology And Genetics Through Multivariate Analysis Of Complex Traits
Funder
National Health and Medical Research Council
Funding Amount
$476,981.00
Summary
There is overlap in risk factors across multiple diseases, and some of that overlap is due to genetic factors. The availability of genome-wide DNA data on tens of thousands of patients for multiple diseases and healthy controls allows new questions to be asked and answered. For example, what is the overlap due to genes in disease risk for multiple sclerosis and rheumatoid arthritis? This project will develop and statistical genetic methodology to answer such questions and apply those methods to ....There is overlap in risk factors across multiple diseases, and some of that overlap is due to genetic factors. The availability of genome-wide DNA data on tens of thousands of patients for multiple diseases and healthy controls allows new questions to be asked and answered. For example, what is the overlap due to genes in disease risk for multiple sclerosis and rheumatoid arthritis? This project will develop and statistical genetic methodology to answer such questions and apply those methods to a range of important diseases.Read moreRead less
Mortality Among Injecting Drugs Users - A Follow-up Study Of Injecting Drug User Cohorts.
Funder
National Health and Medical Research Council
Funding Amount
$47,500.00
Summary
This study will follow-up injecting drug users that participated in research in the 1990s and 2000s to examine mortality rates in these groups over time. Identifying information from these studies will be cross-referenced with National Death Index data to determine participants that died and the dates of their death. This study will be the first in Australia to determine mortality rates over time in a defined cohort of injecting drug users outside drug treatment settings. Studying a defined grou ....This study will follow-up injecting drug users that participated in research in the 1990s and 2000s to examine mortality rates in these groups over time. Identifying information from these studies will be cross-referenced with National Death Index data to determine participants that died and the dates of their death. This study will be the first in Australia to determine mortality rates over time in a defined cohort of injecting drug users outside drug treatment settings. Studying a defined group overcomes some of the problems associated with mortality rate estimates based simply on the number of injecting drug-related deaths. Although the number of deaths can be found, the number of people at risk of injecting drug-related death is unclear because of the hidden nature of drug use and the dynamic characteristics of drug use and drug markets. The examination of mortality trends among injecting drug users over time can provide insights regarding changes in drug use patterns and markets. For example, this study will examine changes in injecting drug use mortality across periods of high heroin availability in the late '90s and periods of interrupted heroin supply - the heroin 'drought' - from 2000 onwards. In addition, factors related to injecting drug-related mortality can be explored by comparing the characteristics of injecting drug users that died and those that survived, such as drug use and drug treatment histories, co-morbidities such as mental illness and socio-demographic backgrounds. This information can inform overdose prevention and harm reduction strategies by identifying individuals most at risk of injecting drug-related mortality. This study will also draw attention to the significant public health burden of injecting drug use. In addition, by comparing the results from this study with other similar studies from overseas, we can more reliably compare mortality among groups of Australian injecting drug users with their peers in other countries.Read moreRead less
REDucing Delays In Aneurysmal Subarachnoid Haemorrhage: The REDDISH Study
Funder
National Health and Medical Research Council
Funding Amount
$436,022.00
Summary
Aneurysmal subarachnoid haemorrhage (aSAH) is a rare form of stroke that kills at least 30% of sufferers within 1 month. Outcome can be improved through quickly receiving medical care but many people do not and this likely contributes to the poor outcomes. The REDucing Delays In Subarachnoid Haemorrhage (REDDISH) study will look at cases of aSAH across Tasmanian and Victoria so that we can understand the factors that contribute to delays in treatment and ultimately improve outcomes.