Addressing the uncertainties: Pathways, fate and associated risks of manufactured nanoparticles in the environment. Manufactured nanomaterials are increasingly present in commercial products, such as sunscreens, textiles and building materials. Their subsequent release to the environment is unavoidable. This project will deliver novel methods for assessing the associated risks, thereby supporting the safe and sustainable use of nanomaterials in Australia.
Is mass commercialisation of silver-based nanotechnology undermining its biomedical antibacterial potential? Silver nanoparticles have demonstrated broad spectrum antibacterial potential and are increasingly used in biomedical applications to limit infection. They are also found in a growing range of everyday products such as shampoos and socks. This situation is analogous to the previous use of antibiotics for nonmedical purposes and the subsequent spread of antibiotic resistant bacteria. This ....Is mass commercialisation of silver-based nanotechnology undermining its biomedical antibacterial potential? Silver nanoparticles have demonstrated broad spectrum antibacterial potential and are increasingly used in biomedical applications to limit infection. They are also found in a growing range of everyday products such as shampoos and socks. This situation is analogous to the previous use of antibiotics for nonmedical purposes and the subsequent spread of antibiotic resistant bacteria. This project will measure silver resistance selection pressure in key microbial communities. Novel monitoring devices, a multi-technique chemistry approach, and correlative synchrotron spectroscopy and molecular biology techniques will be used to decipher the environmental silver resistome and its likely significance.Read moreRead less
From Biodiversity to Health: Performing the first genetic audits of Australia. This project will establish a new technology for the rapid measurement of environmental biodiversity, whether that be in natural resources such as forests, or pathogens in water supplies or hospitals. The method is fast, low-cost and will provide much higher resolution than current methods. It will provide some of the first ever comprehensive environmental impact assessments, permitting responsible resource developmen ....From Biodiversity to Health: Performing the first genetic audits of Australia. This project will establish a new technology for the rapid measurement of environmental biodiversity, whether that be in natural resources such as forests, or pathogens in water supplies or hospitals. The method is fast, low-cost and will provide much higher resolution than current methods. It will provide some of the first ever comprehensive environmental impact assessments, permitting responsible resource development with major benefits to industry and the economy. It also provides a common platform for government agencies, from Department of Environment and Heritage to the Federal Police, and will create new tools to improve water management, biosecurity, forensics/policing and human health, as reflected by the wide range of industry partners supporting the project.Read moreRead less
Coverage with Evidence Development: Application to pharmaceutical reimbursement decisions. Some new medicines produce only a small improvement in health but have considerable costs. When these medicines are trialled on only small numbers of people, uncertainty results about the value of the medicine, which can create problems for decision makers. Funding medicines where there is uncertainty may lead to harm when medicines are later found to be unsafe, or waste millions of dollars when they are ....Coverage with Evidence Development: Application to pharmaceutical reimbursement decisions. Some new medicines produce only a small improvement in health but have considerable costs. When these medicines are trialled on only small numbers of people, uncertainty results about the value of the medicine, which can create problems for decision makers. Funding medicines where there is uncertainty may lead to harm when medicines are later found to be unsafe, or waste millions of dollars when they are overpriced relative to effectiveness. Not funding medicines may disadvantage patients in whom the medicines are effective. Methods to enable access to medicines while reducing uncertainty will offer significant benefit to patients, clinicians and taxpayers. Read moreRead less
Stigma and discrimination and their detrimental impact on social inclusion and health and well-being. Experiencing stigma and discrimination harms health and wellbeing, and prevents people from being fully included in society. This project will help us understand how to best reduce stigma and discrimination, and to protect people from their negative effects.
Closing the gap in Aboriginal maternal and child health outcomes. This project will build the evidence base needed to design and implement effective strategies to close the gap in Aboriginal maternal and child health outcomes and reduce Indigenous disadvantage across the life course.
Strengthening the evidence: how community-based Indigenous health and wellbeing interventions work to improve policy and practice. Indigenous Australians suffer high rates of premature morbidity and mortality. Despite the need for programs to improve Indigenous health and wellbeing, there is little evidence to indicate which community-based programs are effective and why they are effective. This research program addresses this 'need-evidence' gap to inform policy and practice.
Dead Heart Beating? Landscape, Climate and People in Desert Australia. This project aims to undertake the first detailed investigation of the archaeology, landscape history and paleoenvironment of dryland lakes in the Simpson, Strzelecki and Stuart Stony Deserts in Central Australia. Using cutting edge methods, the project expects to discover new archaeological sites, provide a new climate record for inland Australia and develop innovative new analytical and field techniques. Expected benefits a ....Dead Heart Beating? Landscape, Climate and People in Desert Australia. This project aims to undertake the first detailed investigation of the archaeology, landscape history and paleoenvironment of dryland lakes in the Simpson, Strzelecki and Stuart Stony Deserts in Central Australia. Using cutting edge methods, the project expects to discover new archaeological sites, provide a new climate record for inland Australia and develop innovative new analytical and field techniques. Expected benefits also include the development of new cutting-edge methodologies for the investigation of Australian desert landscapes, comprehensive baseline data of how this region has evolved prior to European colonization and resolving why no Pleistocene aged archaeological sites have been found in the region.Read moreRead less
Stories from the past: the impact of industrialisation on the human microbiome. This project aims to explore the history and origin of ‘Industrial’ diseases such as obesity, diabetes, heart disease and autism. Non-communicable, ‘Industrial’ diseases are rising at an alarming rate in Australia, and changes to the beneficial microorganisms within the human body (microbiota) may be to blame. This project will explore how human microbiota have changed over the past 100 years in response to cultural, ....Stories from the past: the impact of industrialisation on the human microbiome. This project aims to explore the history and origin of ‘Industrial’ diseases such as obesity, diabetes, heart disease and autism. Non-communicable, ‘Industrial’ diseases are rising at an alarming rate in Australia, and changes to the beneficial microorganisms within the human body (microbiota) may be to blame. This project will explore how human microbiota have changed over the past 100 years in response to cultural, environmental, and lifestyle factors linked with Industrialisation. This approach will allow stories from the past to inform modern medical treatment strategies and public health decisions in the future. The project will identify changes in environment, diet, hygiene, and medicine that have altered human microbiota in the past and sparked the Industrial disease epidemic in Australia today.Read moreRead less
Kelp forest ecosystems near and far: Putting a new theory explaining dynamic ecological systems to the test. Few, if any, ecological models account for the biological diversity and observed vulnerability of ecosystems, from the molecular to the oceanic scale. This project aims to investigate kelp forests in ways that integrate previously disparate approaches to the study of ecosystems in order to prove the value of a novel framework for understanding how broad-scale and local phenomena interrela ....Kelp forest ecosystems near and far: Putting a new theory explaining dynamic ecological systems to the test. Few, if any, ecological models account for the biological diversity and observed vulnerability of ecosystems, from the molecular to the oceanic scale. This project aims to investigate kelp forests in ways that integrate previously disparate approaches to the study of ecosystems in order to prove the value of a novel framework for understanding how broad-scale and local phenomena interrelate to maintain the diversity and function of ecosystems or to provoke their decline, transition or collapse. This new conceptualisation of ecosystem processes will assist in forecasting the consequences of their management and the effects of external stimuli on normally robust systems. Read moreRead less