HDL Elevation And Glucose Metabolism: A Mechanistic Proof-of-Concept Intervention Trial In Pre-Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$507,974.00
Summary
This clinical trial will investigate a new treatment strategy for type 2 diabetes. Building on our novel discovery that HDL (good cholesterol) lowers blood glucose, we will test whether HDL elevation over a month with a new drug (RVX-208) can improve glucose control in patients with pre-diabetes. If positive, these studies will support new therapeutic approaches to raise levels of circulating HDL for indications beyond vascular disease to manage type 2 diabetes.