Long-term Implications And Outcomes Of Anti Hepatitis B Virus (HBV) Treatment In HIV-HBV Co-infection
Funder
National Health and Medical Research Council
Funding Amount
$293,931.00
Summary
Chronic hepatitis B (HBV) infection may cause serious liver disease in some people, including liver failure or liver cancer. Being infected with both HBV and HIV increases the chances of these complications occurring and the rate they develop. The optimal long term management of HIV-HBV co-infection remains unclear; and the effects of antiretroviral therapy on liver disease progression outcome is unknown in the setting of HIV-HBV co-infection.
Mechanisms Underlying Growth, Lineage Commitment And Differentiation Of Liver Progenitor Cells
Funder
National Health and Medical Research Council
Funding Amount
$535,333.00
Summary
Liver disease is a serious health problem. Viral hepatitis, obesity and alcohol can result in end-stage liver disease. Organ transplant is the only treatment available. A widening gap between organ donations and recipients mandates alternative treatments are developed. Cell transplantation and artificial liver devices are alternatives which can use liver progenitor cells. We will investigate how factors grow and convert them into liver cells for treating liver disease patients.