Immediate Or Delayed Cord Clamping In The Preterm Birth Transition: Is There A Trade-off Between Circulatory Stability And Sympathoadrenal Activation?
Funder
National Health and Medical Research Council
Funding Amount
$824,582.00
Summary
Using an established experimental model of preterm birth, this project will determine if delayed clamping of the umbilical cord at birth leads to better stability of the circulation than immediate clamping, and if this improved stability comes at a cost of not activating the involuntary nervous system essential for enhancing metabolic and lung function after birth. The results of this study will provide fundamental new information for optimizing birth delivery strategies in preterm babies.
Novel Therapy For Heart Failure With Preserved Ejection Fraction
Funder
National Health and Medical Research Council
Funding Amount
$1,068,984.00
Summary
Heart failure is a major cardiovascular problem. Up to half of the patients have a specific problem with heart muscle relaxation. There is no effective therapy for this type of heart failure. We will investigate the effects of new treatment approach using a range of experimental and clinical methods. If successful the treatment could move quickly into clinical practice.
Myocardial Structure And Function In Preeclampsia Using Cardiac Magnetic Resonance And Echocardiography
Funder
National Health and Medical Research Council
Funding Amount
$187,322.00
Summary
Preeclampsia is a devastating high blood pressure problem of pregnancy. The only cure is birth of the baby. I believe that the key to understanding why preeclampsia occurs and to better treatments, is to examine the heart in women with preeclampsia using ultrasound and magnetic imaging. Using these safe methods it is anticipated that my research will improve understanding of preeclampsia, lead to better monitoring and the use of different medications to reduce complications in preeclampsia.
Reducing Morbidities In Preterm Growth Restricted Neonates.
Funder
National Health and Medical Research Council
Funding Amount
$687,214.00
Summary
Intrauterine growth restriction (IUGR) is a serious complication of pregnancy and occurs when fetal growth is abnormal, resulting in a fetus that is smaller than it should be for its given gestational age. IUGR babies are at much greater risk of many short and long-term adverse outcomes. This study investigates the role that adverse cardiovascular development plays in the progression of lung, heart and brain disease in preterm IUGR newborns.
Central Blood Pressure And Cardiovascular Risk In Children Within The General Population And After Repair Of Congenital Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
With an exceptional research standing internationally, and as the leader of a Cardiovascular Bioengineering team, I am developing a new method for assessing central blood pressure in children that will provide better information about early risk of cardiovascular disease than arm blood pressure. This will be applied (1) in a large health study of Australian children and (2) to identify risks and causes of adult-type cardiovascular disease in children with repaired congenital heart disease.
Performance And Safety Testing Of The BioQ Cardiac Assist System In A Chronic Ovine Heart Failure Animal Model
Funder
National Health and Medical Research Council
Funding Amount
$142,800.00
Summary
This proposal will test a novel cardiac assist system in safety and performance studies using a chronic sheep heart failure model. This device has been tested in cardiovascular simulators and in an acute animal model showing attractive proof-of-concept data. Specifically, the device increased left coronary artery blood flow and reduced aortic pulse and mean pressures using our novel self-powered fully implantable stand alone device, a potential therapy treatment for heart failure.