Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100043
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Development of an ultra-high speed spinning disk confocal micro-particle image velocimetry (PIV) platform for the investigation of cardiovascular disease . This facility will establish a microscope system specifically designed to investigate the function of blood cells in the context of cardiovascular diseases such as heart attack and stroke.
A Telehealth Mediated Nursing Intervention (PRISMS) To Enable Patient Monitoring And Self-care In Haematological Cancer Patients: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$936,632.00
Summary
People with cancer are required to monitor and to initiate self care activities to manage side effects at home. In haematological cancer patients these side effects are often severe and life-threatening. Safe home care requires close communication with the health team. We will test if a mobile phone based system can: support patients to monitor their side effects; promote the delivery of evidence based self care advice in a timely manner; and mediate the role of nurses to effectively provide rea ....People with cancer are required to monitor and to initiate self care activities to manage side effects at home. In haematological cancer patients these side effects are often severe and life-threatening. Safe home care requires close communication with the health team. We will test if a mobile phone based system can: support patients to monitor their side effects; promote the delivery of evidence based self care advice in a timely manner; and mediate the role of nurses to effectively provide real-time patient support.Read moreRead less
Determining how calcium regulates mitochondrial function in models of cardiomyopathy. Heart failure is the leading cause of death in Australia. This project will determine the mechanisms by which the failing heart is associated with disorganisation of the cell and poor energy supply so that interventions aimed at reducing the development of heart failure can be developed.
Discovery Early Career Researcher Award - Grant ID: DE160101308
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
An in vitro model of biomaterial-induced thrombosis. This project intends to use bioengineering strategies to develop new methods to understand material interactions with proteins and cells. The project plans to develop microfluidic channels to contain test materials and immobilise a key enzyme associated with thrombosis by plasma immersion ion implantation. This knowledge may increase our understanding of material-biomolecule interactions and have implications for manipulating biological foulin ....An in vitro model of biomaterial-induced thrombosis. This project intends to use bioengineering strategies to develop new methods to understand material interactions with proteins and cells. The project plans to develop microfluidic channels to contain test materials and immobilise a key enzyme associated with thrombosis by plasma immersion ion implantation. This knowledge may increase our understanding of material-biomolecule interactions and have implications for manipulating biological fouling across multiple fields.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102878
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Mobile phone text reminders to modify behaviours and prevent cardiovascular disease. Strategies are needed to improve adherence to behavioural and medical preventative treatments for heart disease. Brief informative reminders sent via mobile phone text message have potential as a cheap and safe method of improving behavioural change and adherence to treatments in people at risk of cardiovascular disease.
Benefits of blood pressure lowering to combat cardiovascular disease. Stroke and heart attack are the commonest causes of death and adult disability. In Australia, approximately 50,000 people die from cardiovascular disease each year. This project will attempt to prevent stroke/heart attack and to improve quality of life by exploring better management of high blood pressure.
Elucidating the post-transcriptional regulation of mast cell proteases. Mast cells (MCs) are immune cells that protect against pathogens but may induce deleterious inflammation. MC function is mediated by specific proteases that are pre-formed and stored in granules. These proteases have unique yet poorly understood mechanisms of regulation. The aim of the project is to use a novel suite of molecular tools and genetically modified mice to identify the critical regions of transcripts that post-tr ....Elucidating the post-transcriptional regulation of mast cell proteases. Mast cells (MCs) are immune cells that protect against pathogens but may induce deleterious inflammation. MC function is mediated by specific proteases that are pre-formed and stored in granules. These proteases have unique yet poorly understood mechanisms of regulation. The aim of the project is to use a novel suite of molecular tools and genetically modified mice to identify the critical regions of transcripts that post-transcriptionally regulate the production and storage of these proteins. The project aims to identify the RNA binding proteins, microRNAs and other novel factors that also regulate them. This is expected to elucidate the post-transcriptional mechanisms of regulation of MC proteases.Read moreRead less
In-vivo detection of airway injury and disease using phase contrast X-ray velocimetry. Currently diagnosis of lung disease, a major cause of death in humans, is based on clinical symptoms that do not usually manifest until the disease is well advanced. This project will develop a novel imaging technique, X-ray velocimetry, to detect changes in tissue before symptoms arise, potentially leading to strategies for managing lung diseases.
Tracking blood and blood products for a healthy start to life. This project will aim to coalesce multiple data sources to track blood and blood products from supply to recipient and improve safe and appropriate blood product transfusions for mothers and newborns. Tracking blood will assist in early identification of adverse outcomes. Identification of at-risk women and babies will allow early prevention and treatment.
Using high performance computing to probe the genesis of cardiac arrhythmias. Disturbances to the normal rhythm of the heart beat cause approximately 15 per cent of deaths in Australia. The project aims to understand how electrical signals in the heart can become chaotic. The project will use computer models of heart rhythm disturbances to help us understand when and how arrhythmias occur.