Optimisation of a novel hybrid vaccine for liver fluke disease in cattle. Optimisation of a novel hybrid vaccine for liver fluke disease in cattle. This project aims to optimise the formulation of novel fluke vaccine antigens by constructing combination hybrid recombinant antigens and using a protein adjuvant to improve immunogenicity, and test new antigens expressed in young flukes as vaccines and evaluate their ability to synergise with hybrid vaccines. Fasciola (fluke) infections cause seriou ....Optimisation of a novel hybrid vaccine for liver fluke disease in cattle. Optimisation of a novel hybrid vaccine for liver fluke disease in cattle. This project aims to optimise the formulation of novel fluke vaccine antigens by constructing combination hybrid recombinant antigens and using a protein adjuvant to improve immunogenicity, and test new antigens expressed in young flukes as vaccines and evaluate their ability to synergise with hybrid vaccines. Fasciola (fluke) infections cause serious economic losses to livestock production and fluke drug resistance threatens control, so new therapies such as a vaccine are needed. These vaccines should be evaluated in cattle trials. The major outcome plan is validation of hybrid antigens for commercial vaccine development for fluke control in cattle, leading to more sustainable beef and milk production in Australia.Read moreRead less
Topical and cryoanaesthesia for livestock husbandry. The livestock industries contribute $15billion annually to Australia's economy, playing a vital role in rural communities. However we must respond to changing demands of our customers, by complementing our competitive disease-free advantage with welfare-conscious production systems. This project will address the threat of growing international demands for improved animal welfare in farming. We will provide research and technical solutions, pro ....Topical and cryoanaesthesia for livestock husbandry. The livestock industries contribute $15billion annually to Australia's economy, playing a vital role in rural communities. However we must respond to changing demands of our customers, by complementing our competitive disease-free advantage with welfare-conscious production systems. This project will address the threat of growing international demands for improved animal welfare in farming. We will provide research and technical solutions, providing pain mangement products for on-farm use that will reduce animal suffering during routine husbandry interventions. The project offers significant benefits for producers by protecting their industries against the threats of a welfare embargo on our livestock products. Read moreRead less
Equine rhinitis A virus; molecular pathogenesis and methods for control. The horse industry in Australia is primarily based in rural locations and is a major contributor to the national economy both in terms of direct economic contribution to gross domestic product and as a major employer of people in regional Australia. The research proposed in this project will improve our understanding of the pathogenesis of a virus that causes respiratory disease in horses that is related to the virus that c ....Equine rhinitis A virus; molecular pathogenesis and methods for control. The horse industry in Australia is primarily based in rural locations and is a major contributor to the national economy both in terms of direct economic contribution to gross domestic product and as a major employer of people in regional Australia. The research proposed in this project will improve our understanding of the pathogenesis of a virus that causes respiratory disease in horses that is related to the virus that causes foot and mouth disease in ruminants and swine. The technology developed during this project would have a global market.Read moreRead less
Development of a novel vaccine targeting parasite tegument proteins for liver fluke disease in livestock. Liver fluke parasites cause serious economic losses for livestock producers in South-East Australia, but drug resistance threatens parasite control and economic productivity in rural communities. This project will use novel technologies to identify lead vaccine candidates for improved fluke control to sustain agricultural productivity.
The infectome of NSW dairy calves, a genomic microbial surveillance . Infectious diseases are the main cause of disease and mortality in calves. The knowledge of the diversity of infectious disease-causing agents in NSW dairy cattle is not comprehensive. Thus, the immediate goal of this proposal is to redress this knowledge gap using untargeted microbial genomic sequencing to characterise and identify known and emerging enteric and respiratory pathogens in dairy calves. We will determine the occ ....The infectome of NSW dairy calves, a genomic microbial surveillance . Infectious diseases are the main cause of disease and mortality in calves. The knowledge of the diversity of infectious disease-causing agents in NSW dairy cattle is not comprehensive. Thus, the immediate goal of this proposal is to redress this knowledge gap using untargeted microbial genomic sequencing to characterise and identify known and emerging enteric and respiratory pathogens in dairy calves. We will determine the occurrence and distribution of their microbial species across all NSW dairy regions. This will enable the Australian dairy industry to improve animal health and productivity, and diagnostic capacity, which will allow farmers to make informed management decisions about disease control strategies. Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC220100050
Funder
Australian Research Council
Funding Amount
$4,508,426.00
Summary
ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (ARC CEA-StAR). The ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance aims to develop industry-led solutions and train a new generation of researchers to combat the impact of antimicrobial resistance (AMR) on agribusiness and the environment.
AMR is a global health and economic threat that epitomises the need for a ‘One Health’ collaborative approach encompassi ....ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (ARC CEA-StAR). The ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance aims to develop industry-led solutions and train a new generation of researchers to combat the impact of antimicrobial resistance (AMR) on agribusiness and the environment.
AMR is a global health and economic threat that epitomises the need for a ‘One Health’ collaborative approach encompassing the interconnection between people, animals, plants, and their shared environment.
Expected outcomes of this collaborative program include a cohort of researchers trained in industry-relevant techniques, furnishing solutions to partner-defined AMR challenges, and providing significant benefits by positioning Australia as a global leader in reducing AMR.Read moreRead less