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New Boron and Gadolinium Agents for Neutron Capture Therapy. The development of new drugs and treatments for cancer is highly important for improved health outcomes and the well-being of the community. This research has the potential to result in the development of new anticancer pharmaceuticals that will dramatically expand the clinical efficacy of a promising treatment for highly aggressive tumours. The innovative nature of this research will also contribute to Australia's science knowledge ....New Boron and Gadolinium Agents for Neutron Capture Therapy. The development of new drugs and treatments for cancer is highly important for improved health outcomes and the well-being of the community. This research has the potential to result in the development of new anticancer pharmaceuticals that will dramatically expand the clinical efficacy of a promising treatment for highly aggressive tumours. The innovative nature of this research will also contribute to Australia's science knowledge base, a key element in its future economic prosperity, and it will provide excellent training of young researchers for employment in the rapidly expanding field of drug design and development.Read moreRead less
Algorithmic approaches to braids and their generalisations. This project combines theoretical methods from pure mathematics with computational experiments in order to gain new knowledge. The objects of interest, so-called braid groups and generalisations, are important for many fields of mathematics, but also have applications for data security. Both the theoretical outcomes of this project and the algorithms developed will strengthen Australia as a centre of cutting-edge research in computatio ....Algorithmic approaches to braids and their generalisations. This project combines theoretical methods from pure mathematics with computational experiments in order to gain new knowledge. The objects of interest, so-called braid groups and generalisations, are important for many fields of mathematics, but also have applications for data security. Both the theoretical outcomes of this project and the algorithms developed will strengthen Australia as a centre of cutting-edge research in computational algebra. Moreover, the results can lead to new technologies for protecting confidential data, which are more efficient and hence cheaper to implement than existing alternatives. Secure identification of legitimate users in the context of online banking is one possible field of application.Read moreRead less
Scale-Multiplicative Semigroups and Geometry. Symmetry is treated mathematically through the algebraic concept of a group. Conversely, geometric representations play a crucial role in group theory. Many classes of groups, such as the connected groups that arise in physics, have useful geometric representations, but such a representation is lacking in the case of general disconnected groups. Certain disconnected groups, closely related in algebraic terms to the connected ones, do have a geometric ....Scale-Multiplicative Semigroups and Geometry. Symmetry is treated mathematically through the algebraic concept of a group. Conversely, geometric representations play a crucial role in group theory. Many classes of groups, such as the connected groups that arise in physics, have useful geometric representations, but such a representation is lacking in the case of general disconnected groups. Certain disconnected groups, closely related in algebraic terms to the connected ones, do have a geometric representation called a 'building'. This project aims to address the lack of a representation for general disconnected groups by extending the notion of a building to create combinatorial structures on which these groups act as symmetries.Read moreRead less
Totally disconnected groups and their algebras. Groups are algebraic objects which convey symmetry much as
numbers convey size. For example, the symmetries of a
crystal form a crystallographic group and the classification of
crystallographic groups describes all possible crystal
structures. Totally disconnected groups arise as
symmetries of network structures having nodes and a `neighbour'
relation, as models of crystals do, but which are not rigid like
crystals. Powerful techniques for a ....Totally disconnected groups and their algebras. Groups are algebraic objects which convey symmetry much as
numbers convey size. For example, the symmetries of a
crystal form a crystallographic group and the classification of
crystallographic groups describes all possible crystal
structures. Totally disconnected groups arise as
symmetries of network structures having nodes and a `neighbour'
relation, as models of crystals do, but which are not rigid like
crystals. Powerful techniques for analysing totally
disconnected groups have recently been discovered and this
project aims to develop those techniques. The resulting
significant advances in the understanding of symmetry will
extend the range of applications of
group theory.
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Totally disconnected groups in algebra and geometry. Mathematics research creates and develops new concepts for understanding the world. Group theory is a branch of mathematics based on our innate sense of symmetry. It was invented 200 hundred years ago and has grown into a language for analysing and classifying things ranging from wallpaper patterns to crystals, the fundamental particles of physics and Rubik's cube. The chief investigators have made significant breakthroughs in the study of sym ....Totally disconnected groups in algebra and geometry. Mathematics research creates and develops new concepts for understanding the world. Group theory is a branch of mathematics based on our innate sense of symmetry. It was invented 200 hundred years ago and has grown into a language for analysing and classifying things ranging from wallpaper patterns to crystals, the fundamental particles of physics and Rubik's cube. The chief investigators have made significant breakthroughs in the study of symmetry groups of networks, giving Australia an international lead in this research area. The project will develop the insights gained to make Australia a centre of expertise on these symmetry groups, which have applications to many areas including information and communication technology.Read moreRead less
The mathematics and language of engineering uncertainty, preference and utility. Australian engineering firms are principals in many high-profile projects. To defend their position, they must demonstrate both sound engineering and quality processes, which by international standards includes the traceability of decisions. Yet, there are few tools to vet the multitude of decisions that go into large-scale engineering works. This project aims to form mathematical models of decision-making based on ....The mathematics and language of engineering uncertainty, preference and utility. Australian engineering firms are principals in many high-profile projects. To defend their position, they must demonstrate both sound engineering and quality processes, which by international standards includes the traceability of decisions. Yet, there are few tools to vet the multitude of decisions that go into large-scale engineering works. This project aims to form mathematical models of decision-making based on the language modelling of what is written in engineering documentation about the bases of decisions. The new methods will help decision makers to pinpoint irrationalities in decisions and notify them of possible errors. The research can therefore be applied to important problems in the engineering sector such as risk management.Read moreRead less
Constructive Representation Theory and its Applications. The algorithms developed will make it possible to determine the different ways (representations) in which a group of symmetries may be realised as transformations of some space. Such knowledge is required in many areas including differential equations, digital signal processing, engineering ('strut-and-cable' constructions), the design of telephone networks, crystallography and quantum information processing. The high-performance tools fo ....Constructive Representation Theory and its Applications. The algorithms developed will make it possible to determine the different ways (representations) in which a group of symmetries may be realised as transformations of some space. Such knowledge is required in many areas including differential equations, digital signal processing, engineering ('strut-and-cable' constructions), the design of telephone networks, crystallography and quantum information processing. The high-performance tools for linear algebra developed will also find application in cryptography and coding theory. This work represents the latest stage in a long-term project to discover practical algorithms for elucidating the properties of complex algebraic structures - an area where Australia is a world-leader.Read moreRead less
New frontiers in the therapeutic application of gadolinium. This research involves the design and development of new anticancer agents that will dramatically expand the clinical efficacy of a promising treatment for highly aggressive tumours. The innovative nature of this research will also contribute to Australia's science knowledge base and provide excellent training in the area of drug discovery.
Computational Methods for Matrix Groups and Group Representations. The symmetry of a system is captured mathematically by the notion of a group. A set of matrices closed under multiplication and the taking of inverses is an important example of a group. For instance, the symmetries of many physical systems and other objects are captured by a group of matrices over the complex numbers. This project will develop the computational tools necessary for constructing and analyzing finite matrix groups ....Computational Methods for Matrix Groups and Group Representations. The symmetry of a system is captured mathematically by the notion of a group. A set of matrices closed under multiplication and the taking of inverses is an important example of a group. For instance, the symmetries of many physical systems and other objects are captured by a group of matrices over the complex numbers. This project will develop the computational tools necessary for constructing and analyzing finite matrix groups over infinite fields such as the complex numbers. These methods will find immediate application to many areas of science and engineering and, in particular, to the theory of quantum computation.
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Group 13 Mixed Halide-Hydride and Rare Earth Complexes - New Selective Chiral Hydridic or Low Valent Reducing Agents. This project will make a landmark contribution to two areas of metallohydride chemistry. Both studies will utilise and develop metals that have traditionally been mined and exported from these shores while concurrently imported as value added products at vastly inflated cost. This research will identify knock-on applications in order to stem this financial bias. The new paths to ....Group 13 Mixed Halide-Hydride and Rare Earth Complexes - New Selective Chiral Hydridic or Low Valent Reducing Agents. This project will make a landmark contribution to two areas of metallohydride chemistry. Both studies will utilise and develop metals that have traditionally been mined and exported from these shores while concurrently imported as value added products at vastly inflated cost. This research will identify knock-on applications in order to stem this financial bias. The new paths to rare earth (= Ln) hydrides will have broad industrial appeal, particularly for new materials, where, like similar group 13 materials, they may be used in the deposition of Ln films or even as precursors to superconducting solids. It is anticipated industrial collaboration will ensue. Australia will be promoted as a developer and innovator of frontier technologies.Read moreRead less