Genome-wide Association Studies To Identify Major Genetic Determinants Of 5 Blinding Eye Diseases Using Pooled DNA
Funder
National Health and Medical Research Council
Funding Amount
$562,193.00
Summary
This project aims to find important genes for 5 diseases that can lead to blindness. We will use a cost-effective approach where samples from a large number of individuals with a given disorder are pooled (mixed together) and then compared on gene chips covering the whole genome to a pool of people who do not have the disease. Differences identified between the groups will point to genes causing that disease. We will identify any major genes for the 5 diseases being studied.
Retinal Ganglion Cell Bioenergetics With Clinical Translation
Funder
National Health and Medical Research Council
Funding Amount
$725,913.00
Summary
Glaucoma is an eye disease where elevated pressure within the eye damages the sensitive nerve of sight at the back of the eye. The only current treatment is to lower the pressure in the eye with either drops, laser or surgery. Why the pressure damages the nerve of sight is unclear but there is evidence that it results in a reduced blood flow to the nerve. This starves the nerve of nutrients. We have developed a new treatment that supplies nutrients to the nerve and protects vision.
Boosting Mitochondria- A New Approach For Protecting The Aging Optic Nerve In Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$391,784.00
Summary
Increasing age is a major risk factor for neurodegeneration. We have recently shown that subjecting mice to intermittent periods of fasting improves mitochondrial function in the retina and reverses age-related decline in optic nerve vulnerability to injury. This project now aims to investigate key molecular pathway for restoring mitochondria and from this attempts to find more palatable therapeutic strategies for protecting the optic nerve from injury.
High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
Translation Of Glaucoma Blindness Genes To Improve Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$856,795.00
Summary
Glaucoma is a common cause of irreversible blindness. It is currently difficult to predict which patients with the earliest signs of glaucoma will develop blinding stages of the disease. This study will investigate how genes and eye measurements can be used to predict the risk of developing severe glaucoma in people with early signs of disease. This will ensure that high risk individuals can access treatment early, while those at low risk can be spared unnecessary treatment and seen less often.
Gene Tests For Predicting Risk Of Developing Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$956,020.00
Summary
Glaucoma is a common cause of blindness. It is currently difficult to predict which patients with the earliest signs of glaucoma will go on to develop the blinding stages of the disease. This study will investigate how genes and othe eye measurements can be used to predict risk of developing glaucoma in people with early signs of disease.
Functional Analysis Of Recently Identified Novel Glaucoma Genes.
Funder
National Health and Medical Research Council
Funding Amount
$519,918.00
Summary
Glaucoma is the commonest cause of irreversible blindness in the world. Recently, through genetic studies in cohorts of blinding glaucoma cases from Australia, our group has found that variants in two genes increase the risk of blinding glaucoma. This project will investigate how these genes contribute to pathological changes in the optic nerve and retina, at the back of the eye, that lead to glaucoma. This knowledge will be useful for developing new strategies to treat glaucoma.
Comparing The Effectiveness Of Selective Laser Trabeculoplasty With Topical Medication For The Treatment Of Primary Angle Closure Glaucoma: A Multicentred, Prospective, Randomized Controlled Clinical Trial.
Funder
National Health and Medical Research Council
Funding Amount
$639,888.00
Summary
The main treatment of glaucoma, an eye condition which causes peripheral vision loss and blindness, involves the use of eye drops. However, these are expensive, have considerable side effects, and impact negatively on daily living. Laser has recently been proposed as an alternative treatment and, in this project, we will investigate the effectiveness of laser compared to medication. We anticipate laser will be more cost effective, safer, and have a positive impact on quality of life compared to ....The main treatment of glaucoma, an eye condition which causes peripheral vision loss and blindness, involves the use of eye drops. However, these are expensive, have considerable side effects, and impact negatively on daily living. Laser has recently been proposed as an alternative treatment and, in this project, we will investigate the effectiveness of laser compared to medication. We anticipate laser will be more cost effective, safer, and have a positive impact on quality of life compared to eye drops.Read moreRead less